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6-Chloro-3-methyluracil

6-Chloro-3-methyluracil structure

CAS No.: 4318-56-3

Chemical Name:: 6-Chloro-3-methyluracil

Synonyms: 6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione;3-METHYL-6-CHLOROURACIL;6-chloro-2-hydroxy-3-MethylpyriMidin-4(3H)-one;Chloro-3-Methylura;6-Chloro-3-Methyuracil;3-METHYL-6-CHLOROURACI;Alogliptin Impurity 86;6-Chloro-3-methyluraci;6-CHLORO-3-METHYLURACIL;6-Chloro-3-dimethyl uracil

CBNumber:: CB9283127

Molecular Formula:: C5H5ClN2O2

Molecular Weight:: 160.56

MDL Number:: MFCD01074837

MOL File:: 4318-56-3.mol

MSDS File:: SDS

Last updated:2026-05-28 06:22:47

Product description	Number	Pack Size	Price
6-Chloro-3-methyluracil ≥98%	713465	100g	$320
6-Chloro-3-methyluracil >98.0%(HPLC)(T)	C2300	5g	$29
6-Chloro-3-methyluracil >98.0%(HPLC)(T)	C2300	25g	$89
6-Chloro-3-methyluracil Asreported	267413	50g	$337
6-Chloro-3-methyluracil Asreported	267413	100g	$468
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6-Chloro-3-methyluracil Properties

Melting point	278-280°C (dec.)
Density	0,896 gr/cm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	7.16±0.40(Predicted)
color	White to Almost white
BRN	511456
InChI	InChI=1S/C5H5ClN2O2/c1-8-4(9)2-3(6)7-5(8)10/h2H,1H3,(H,7,10)
InChIKey	SGLXGFAZAARYJY-UHFFFAOYSA-N
SMILES	C1(=O)NC(Cl)=CC(=O)N1C
CAS DataBase Reference	4318-56-3(CAS DataBase Reference)
FDA UNII	AYQ4JL346J
UNSPSC Code	41106305
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

UN 1992

WGK Germany

Hazard Note

Irritant

HS Code

29335990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	0
2		0

6-Chloro-3-methyluracil price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	713465	6-Chloro-3-methyluracil ≥98%	4318-56-3	100g	$320	2026-04-30	Buy
TCI Chemical	C2300	6-Chloro-3-methyluracil >98.0%(HPLC)(T)	4318-56-3	5g	$29	2026-04-30	Buy
TCI Chemical	C2300	6-Chloro-3-methyluracil >98.0%(HPLC)(T)	4318-56-3	25g	$89	2026-04-30	Buy
Usbiological	267413	6-Chloro-3-methyluracil Asreported	4318-56-3	50g	$337	2026-06-03	Buy
Usbiological	267413	6-Chloro-3-methyluracil Asreported	4318-56-3	100g	$468	2026-06-03	Buy

Product number	Packaging	Price	Buy
713465	100g	$320	Buy
C2300	5g	$29	Buy
C2300	25g	$89	Buy
267413	50g	$337	Buy
267413	100g	$468	Buy

6-Chloro-3-methyluracil Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

6-Chloro-3-methyluracil have been used in the synthesis of antibacterial agents as inhibitors of Helicobacter pylori glutamate racemase.

Definition

ChEBI: 6-Chloro-3-methyluracil is a member of pyrimidines and an organohalogen compound.

Synthesis

2565-47-1

4318-56-3

General procedure for the synthesis of 3-methyl-6-chlorouracil from 1-methylpyrimidine-2,4,6(1H,3H,5H)-trione: Water (2.7 mL) was added slowly and dropwise at 0 °C to a 1-methylpyrimidine-2,4,6(1H,3H,5H)-trione (14.2 g, 100 mmol) formed with phosphorus oxychloride (POCl3, 95 mL) in a in a suspension. Subsequently, the reaction mixture was warmed to 80 °C and maintained for 5 hours. Upon completion of the reaction, the resulting brown solution was cooled and the POCl3 was evaporated under reduced pressure.The residue was treated with methanol (MeOH) and the resulting solid was purified by recrystallization from ethanol to give 11.5 g of 3-methyl-6-chlorouracil (yield: 71.6%). The melting point of the product was 279-282 °C (decomposition), which is consistent with literature values (280-282 °C).1H NMR (400 MHz, DMSO-d6) δ 3.10 (s, 3H), 5.90 (s, 1H), 12.4 (br s, 1H).

References

[1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 3, p. 594 - 597
[2] Tetrahedron Asymmetry, 1997, vol. 8, # 14, p. 2319 - 2323
[3] Patent: WO2009/73210, 2009, A1. Location in patent: Page/Page column 76
[4] Patent: WO2006/133261, 2006, A2. Location in patent: Page/Page column 30
[5] Patent: WO2007/143705, 2007, A2. Location in patent: Page/Page column 23

6-Chloro-3-methyluracil Preparation Products And Raw materials

Raw materials

N-METHYLBARBITURIC ACID

Preparation Products

2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,6-dimethyl-3-[4-(trifluoromethoxy)phenyl]-

6-Chloro-3-methyluracil Suppliers

Global( 699)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	427	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Handan City Zechi trading Co., LTD	+8619003396151	13165586887@163.com	China	475	58
Springchem New Material Technology Co.,Limited	+86-021-62885108 +8613917661608	info@spring-chem.com	China	2068	57
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Firsky International Trade (Wuhan) Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Handan City Zechi trading Co., LTD	58
Springchem New Material Technology Co.,Limited	57
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Chembon Pharmaceutical Co., Ltd.	55

View Lastest Price from 6-Chloro-3-methyluracil manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-05	6-Chloro-3-methyluracil 4318-56-3		1kg	98%min	500kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-05-05	6-Chloro-3-methyluracil 4318-56-3	$200.00-2000.00	1KG	0.99	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd
2026-03-20	6-Chloro-3-methyluracil 4318-56-3	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

6-Chloro-3-methyluracil
4318-56-3
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

6-Chloro-3-methyluracil
4318-56-3
$200.00-2000.00
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

6-Chloro-3-methyluracil
4318-56-3
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

6-Chloro-3-methyluracil Spectrum

6-Chloro-3-methyluracil(4318-56-3)¹HNMR

4318-56-3(6-Chloro-3-methyluracil)Related Search:

METSULFURON METHYL Methyl acetate 4-(Chloromethyl)benzoic acid 2-Chloro-5-chloromethylpyridine CHLOROMETHYLPHENYLSILANE

Methyl acrylate Uracil Bensulfuron methyl DIMETHYLTHEXYLSILYL CHLORIDE Chloromethyltrimethylsilane

Methylparaben Kresoxim-methyl 2-Pyridinamine, 6-chloro-5-methyl Thiophanate-methyl tert-Butyldimethylsilyl chloride

Methyl Parathion-methyl Methyl bromide

1of4

6-chloro-3-methyl-2,4(1H,3H)-pyrimidinedione 6-Chloro-3-dimethyl uracil 3-METHYL-6-CHLOROURACI 6-Chloro-3-Methyuracil 3-Methyl-6-chlorouracil, GC 97% 3-METHYL-6-CHLOROURACIL 6-CHLORO-3-METHYLURACIL 6-CHLORO-3-METHYLURACIL, 98+% 6-Chloro-3-methyluracil ,99% 2,4(1H,3H)-pyrimidinedione, 6-chloro-3-methyl- 6-chloro-3-Methyl-1,2,3,4-tetrahydropyriMidine-2,4- dione 6-chloro-3-trideuterioMethyluracil 6-chloro-2-hydroxy-3-MethylpyriMidin-4(3H)-one 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, 4-Chloro-2,6-dioxo-1-methyl-1,2,3,6-tetrahydropyrimidine Alogliptin Benzoate interMediate D Chloro-3-Methylura 6-chloro-3-methyl-1H-pyrimidine-2,4-dione Uracil, 6-chloro-3-methyl- 6-chloro-3-methyl-1H-pyrimidine-2,4(1H,3H)-dione 2-(propan-2-ylthio)ethanol 6-Chloro-3-methyluracil > Alogliptin Impurity 86 Trelagliptin & Alogliptin intermediates，6-Chloro-3-methyluracil Alogliptin Intermediate 4 OR Trelagliptin Intermediate 6-Chloro-3-Methyluracil / Trelagliptin Intermediate / Alogiptin Intermeidate 2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,9-dione Alogliptin intermediate 3-Methyl-6-Chlorouracil 6-Chloro 3-Methyl Uracil Impurity 6-Chloro-3-methyluracil , 95% 6-Chloro-3-methyluraci 6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione 4318-56-3 4138-56-3 4315-56-3 C5H5N2O2Cl C5H5ClN3O2 C5H5ClN2O2 Intermediates Pyrimidine Biochemistry Nucleobases and their analogs Nucleosides, Nucleotides & Related Reagents API 4318-56-3