2-Amino-4-(trifluoromethyl)benzenemethanol
- CAS No.
- 186602-93-7
- Chemical Name:
- 2-Amino-4-(trifluoromethyl)benzenemethanol
- Synonyms
- (2-amino-4-(trifluoromethyl)phenyl)methanol;2-Amino-4-(trifluoromethyl)benzenemethanol;2-amino-4-(trifluoromethyl)phenyl]methan-1-ol;Benzenemethanol, 2-amino-4-(trifluoromethyl)-
- CBNumber:
- CB93036317
- Molecular Formula:
- C8H8F3NO
- Molecular Weight:
- 191.15
- MDL Number:
- MFCD17215842
- MOL File:
- 186602-93-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Warning |
| Hazard statements | H290-H318 |
| Precautionary statements | P280-P305+P351+P338-P310-P390-P406b-P501c |
2-Amino-4-(trifluoromethyl)benzenemethanol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS113090 | (2-Amino-4-(trifluoromethyl)phenyl)methanol 95% | 186602-93-7 | 1g | $330 | 2026-06-04 | Buy |
| Matrix Scientific | 292769 | (2-Amino-4-(trifluoromethyl)phenyl)methanol | 186602-93-7 | 250.00mg | $54 | 2026-05-19 | Buy |
| Matrix Scientific | 292769 | (2-Amino-4-(trifluoromethyl)phenyl)methanol | 186602-93-7 | 1.00g | $200 | 2026-05-19 | Buy |
| Matrix Scientific | 292769 | (2-Amino-4-(trifluoromethyl)phenyl)methanol | 186602-93-7 | 5.00g | $756 | 2026-05-19 | Buy |
| Synthonix | A49064 | (2-Amino-4-(trifluoromethyl)phenyl)methanol 95% | 186602-93-7 | 100mg | $28 | 2026-05-06 | Buy |
2-Amino-4-(trifluoromethyl)benzenemethanol Chemical Properties, Uses, Production
Synthesis
402-13-1
186602-93-7
General procedure for the synthesis of (2-amino-4-(trifluoromethyl)phenyl)methanol from 2-amino-4-trifluoromethylbenzoic acid: representative method for the preparation of 2-amino-4-(trifluoromethyl)benzyl alcohol (17a): 2-amino-4-trifluoromethylbenzoic acid (16a, 2.04 g, 10 mmol) and NaBH4 (0.912 g, 24 mmol) were were suspended in THF (10 mL). A solution of iodine (I2, 2.54 g, 10 mmol) in THF (10 mL) was slowly added at 0°C over 10-15 min under nitrogen protection. The reaction mixture was stirred at room temperature for 30 min, followed by heating and reflux stirring for 24 hr. Upon completion of the reaction, the mixture was cooled to room temperature and MeOH was slowly added until a clarified solution was formed. The solvent was removed under reduced pressure and the residue was stirred with 20% aqueous KOH solution (20 mL) for 4 hours at room temperature. The reaction mixture was extracted with CH2Cl2 (3 x 100 mL) and the organic phase was dried with anhydrous Na2SO4 and concentrated under reduced pressure to give the target alcohol 17a (1.91 g, 100% yield).1H NMR (CDCl3, 300 MHz): δ 7.15 (d, 1H, J = 7.5 Hz), 6.94 (d, 1H, J = 7.5 Hz), 6.91 ( s, 1H), 4.71 (s, 2H).
References
[1] Patent: WO2005/30774, 2005, A1. Location in patent: Page/Page column 20
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5810 - 5831
[3] Angewandte Chemie, International Edition, 2014, vol. 53, # 36, p. 9603 - 9607,5
[4] Angewandte Chemie, 2014, vol. 126, # 36, p. 9757 - 9761,5
[5] Organic Letters, 2015, vol. 17, # 19, p. 4750 - 4753
2-Amino-4-(trifluoromethyl)benzenemethanol Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-4-(trifluoromethyl)benzenemethanol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6746 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd | 0371-88900765 18037465274 | 3430974218@qq.com | China | 14171 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49299 | 58 |
| Shanghai Pengque Chemical Technology Co., LTD | 15317013857 15901926503 | pengque01@sina.com | China | 977 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39796 | 58 |
