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ZA7371

ZA7371 Structure
ZA7371 structure
CAS No.
1494675-86-3
Chemical Name:
ZA7371
Synonyms
ZA7371;AZ-7371;CS-1538;TBA-7371;DprE1-IN-1;AZ7371;AZ 7371;DprE1-IN-1 ZA7371;ZA 7371 TBA-7371;DprE1-IN-1 (AZ7371;AZ-7371(DprE1-IN-1)
CBNumber:
CB93060642
Molecular Formula:
C18H21N5O3
Molecular Weight:
355.39
MDL Number:
MFCD29477419
MOL File:
1494675-86-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 16:31:51
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ZA7371 Properties

Boiling point 691.6±55.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 11 mg/mL (30.95 mM)
pka 12.79±0.46(Predicted)
form A crystalline solid
color White to off-white
FDA UNII R3T98GBE3C

ZA7371 price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19310 AZ 7371 ≥98% 1494675-86-3 1mg $49 2026-04-30 Buy
Cayman Chemical 19310 AZ 7371 ≥98% 1494675-86-3 5mg $213 2026-04-30 Buy
Cayman Chemical 19310 AZ 7371 ≥98% 1494675-86-3 10mg $376 2026-04-30 Buy
Cayman Chemical 19310 AZ 7371 ≥98% 1494675-86-3 25mg $762 2026-04-30 Buy
ChemScene CS-5414 TBA-7371 99.61% 1494675-86-3 5mg $32 2026-06-04 Buy
Product number Packaging Price Buy
19310 1mg $49 Buy
19310 5mg $213 Buy
19310 10mg $376 Buy
19310 25mg $762 Buy
CS-5414 5mg $32 Buy

ZA7371 Chemical Properties,Uses,Production

Uses

TBA-7371 is an orally active and non-covalent inhibitor of Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) of Mycobacterium tuberculosis (MIC=0.64 μg/mL). TBA-7371 can block the synthesis of arabinose in the bacterial cell wall, resulting in cell wall structural defects, thereby exerting an anti-tuberculosis effect. TBA-7371 can be used in the research of anti-tuberculosis drugs and has a synergistic bactericidal effect with Bedaquiline (HY-14881) and other drugs[1][2][3].

in vivo

TBA-7371 (100, 200 mg/kg; oral gavage; twice daily; 4-8 weeks) synergistically exerts bactericidal and fungicidal activity with Bedaquiline (HY-14881) and GSK2556286 (HY-147017) in the BALB/c mouse tuberculosis model[3].
TBA-7371 (50, 100, 200 mg/kg; oral gavage; twice daily; 8 weeks) significantly reduces bacterial burden in lung tissue after 8 weeks of treatment in the C3HeB/Fe J mouse tuberculosis model[3].

Animal Model:Female BALB/c mice (5-6 weeks old, specific pathogen-free) + subacute tuberculosis infection model induced by aerosol of *Mycobacterium tuberculosis* H37Rv[3]
Dosage:100 mg/kg, 200 mg/kg (0.5% carboxymethylcellulose + 0.1% Tween 80)
Administration:Oral gavage, twice daily (8 h apart), 5 days/week for 4-8 weeks; Combination with Bedaquiline (25 mg/kg) and GSK2556286 (50 mg/kg) (BGA regimen)
Result:At 100 or 200 mg/kg bid significantly increased bactericidal activity after 8 weeks, with lung CFU counts of 1.48 (200 mg/kg) and 1.78 (100 mg/kg), demonstrating superior sterilizing activity compared to two-drug combinations.
Animal Model:Female C3HeB/FeJ mice (8-10 weeks old, specific pathogen-free) + chronic tuberculosis infection model with caseous necrotic pulmonary lesions induced by aerosol of *Mycobacterium tuberculosis* Erdman[3]
Dosage:50 mg/kg, 100 mg/kg, 200 mg/kg (0.5% carboxymethylcellulose + 0.1% Tween 80)
Administration:Oral gavage, twice daily, 5 days/week for 8 weeks
Result:After 8 weeks, all dose groups showed significant reduction in lung bacterial burden compared to untreated controls.
The 100 and 200 mg/kg groups achieved approximately 1.5 log CFU reduction, with dose-dependent efficacy.
At 100 mg/kg bid exhibited consistent bactericidal activity, with higher drug retention in caseous lesions at trough concentrations.

References

[1] Gawad J, et al. Decaprenyl-phosphoryl-ribose 2'-epimerase (DprE1): challenging target for antitubercular drug discovery. Chem Cent J. 2018 Jun 23;12(1):72. DOI:10.1186/s13065-018-0441-2
[2] Robertson GT, et al. Comparative Analysis of Pharmacodynamics in the C3HeB/FeJ Mouse Tuberculosis Model for DprE1 Inhibitors TBA-7371, PBTZ169, and OPC-167832. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0058321. DOI:10.1128/AAC.00583-21
[3] Li S-Y, et al. Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0156223. DOI:10.1128/aac.01562-23

ZA7371 Preparation Products And Raw materials

Raw materials

Preparation Products

ZA7371 Suppliers

Global( 76)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 info@yuhaochemical.com China 1999 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4861 55
Guangzhou Zhiya Chemdrugs Co.,Ltd 18122150900 sculk28@163.com China 645 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai QianYan Bio-technology Co., Ltd 02781293128 orders@biochemsafebuy.com China 9904 55
Shanghai Changyan Chem & Tech Co., Ltd. 021-20242659 18930833303 sales@changyanchem.cn China 4998 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
HangZhou YuHao Chemical Technology Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Guangzhou Zhiya Chemdrugs Co.,Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai QianYan Bio-technology Co., Ltd 55
Shanghai Changyan Chem & Tech Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62

View Lastest Price from ZA7371 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TBA-7371 pictures 2026-05-11 TBA-7371
1494675-86-3
 $41.00-123.00 99.74% 10g TargetMol Chemicals Inc.
N-(2-Hydroxyethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide pictures 2020-01-02 N-(2-Hydroxyethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
1494675-86-3
 $1.00 1KG Min98% HPLC Career Henan Chemical Co
  • TBA-7371 pictures
  • TBA-7371
    1494675-86-3
  • $41.00-123.00
  • 99.74%
  • TargetMol Chemicals Inc.

ZA7371 Spectrum

ZA7371(1494675-86-3)1HNMR

1494675-86-3(ZA7371)Related Search:

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N-(2-Hydroxyethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide ZA7371 DprE1-IN-1 AZ-7371 AZ-7371(DprE1-IN-1) TBA-7371 DprE1-IN-1 ZA7371 AZ7371;AZ 7371 CS-1538 1H-Pyrrolo[3,2-b]pyridine-3-carboxamide, N-(2-hydroxyethyl)-1-[(6-methoxy-5-methyl-4-pyrimidinyl)methyl]-6-methyl- DprE1-IN-1 (AZ7371 TBA-7371,tuberculosis,Inhibitor,noncovalent,antituberculosis,DprE1,Bacterial,inhibit,TBA 7371,TBA7371,antitubercular ZA 7371 TBA-7371 1494675-86-3