BP-1-102
- CAS No.
- 1334493-07-0
- Chemical Name:
- BP-1-102
- Synonyms
- BP-1-102;STAT3 Inhibitor XVIII;BP-1-102, 10 mM in DMSO;BP-1-102; BP1-102; BP 1-102.;STAT3 Inhibitor XVIII, BP-1-102;STAT3 INHIBITOR XVIII;BP1-102;BP 1-102;4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydr;4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid;BP-1-102,4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-hydroxy-
- CBNumber:
- CB93069948
- Molecular Formula:
- C29H27F5N2O6S
- Molecular Weight:
- 626.59
- MDL Number:
- MFCD29477477
- MOL File:
- 1334493-07-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| BP-1-102 ≥98% | 28368 | 5mg | $134 |
| BP-1-102 ≥98% | 28368 | 10mg | $228 |
| BP-1-102 ≥98% | 28368 | 25mg | $498 |
| BP-1-102 ≥98% | 28368 | 50mg | $795 |
| BP 1-102 | JDC49307 | 50mg | $687 |
| Boiling point | 749.2±70.0 °C(Predicted) |
|---|---|
| Density | 1.474±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO:15.0(Max Conc. mg/mL);23.9(Max Conc. mM) |
| form | A crystalline solid |
| pka | 3.15±0.10(Predicted) |
| color | White to off-white |
| InChIKey | WNVSFFVDMUSXSX-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=O)C=C1O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 | |||||||||
| WGK Germany | WGK 2 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
BP-1-102 price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28368 | BP-1-102 ≥98% | 1334493-07-0 | 5mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 28368 | BP-1-102 ≥98% | 1334493-07-0 | 10mg | $228 | 2026-04-30 | Buy |
| Cayman Chemical | 28368 | BP-1-102 ≥98% | 1334493-07-0 | 25mg | $498 | 2026-04-30 | Buy |
| Cayman Chemical | 28368 | BP-1-102 ≥98% | 1334493-07-0 | 50mg | $795 | 2026-04-30 | Buy |
| Biosynth | JDC49307 | BP 1-102 | 1334493-07-0 | 50mg | $687 | 2026-06-04 | Buy |
BP-1-102 Chemical Properties,Uses,Production
Uses
BP-1-102 is a potent and selective STAT3 inhibitor. STAT3 is a cytoplasmic transcription factor that induces the expression of genes related to tumorigenesis. BP 1-102 exhibits antitumor activity against Waldenstrom macroglobulinemia, a rare form of B cell non-Hodgkin lymphoma.
Biological Activity
Primary Target
Stat3
Synthesis
![Phenylmethyl 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-(phenylmethoxy)benzoate](/CAS/20210305/GIF/1334493-48-9.gif)
1334493-48-9
1334493-07-0
General method: Benzyl-protected salicylic acid (1 eq.) was dissolved in a stirred solvent mixture of methanol/tetrahydrofuran (1:1, v/v, 0.1 M). After thorough degassing, 10% palladium/carbon catalyst (10 mg/mmol) was cautiously added. The solution was bubbled with hydrogen gas for 5 minutes, followed by continuous stirring of the reaction under hydrogen atmosphere for 3 hours. Upon completion of the reaction, the hydrogen was removed, the palladium catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure.
in vivo
Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas[2]. BP-1-102 is orally bioavailable and that the agent accumulates in tumor tissues at levels sufficient to inhibit aberrantly active Stat3 functions and inhibit tumor growth[1].
IC 50
STAT3: 6.8 μM (IC50)
References
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5605 - 5609
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 11, p. 1102 - 1107
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 18, p. 7190 - 7200
BP-1-102 Preparation Products And Raw materials
BP-1-102 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11674 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9935 | 58 |
