BMS-986020
- CAS No.
- 1257213-50-5
- Chemical Name:
- BMS-986020
- Synonyms
- AM152;CS-2492;BMS-986020;AP-3152 free acid;BMS-986020 ，S3572;BMS-986020 (BMS 986020;BMS-986020, 10 mM in DMSO;BMS-986020;BMS 986020;BMS986020;1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-
- CBNumber:
- CB93070650
- Molecular Formula:
- C29H26N2O5
- Molecular Weight:
- 482.53
- MDL Number:
- MFCD30489743
- MOL File:
- 1257213-50-5.mol
| Product description | Number | Pack Size | Price |
| BMS 986020 ≥98% | 22049 | 500μg | $32 |
| BMS 986020 ≥98% | 22049 | 1mg | $61 |
| BMS 986020 ≥98% | 22049 | 5mg | $153 |
| BMS-986020 | B701320 | 25mg | $185 |
| BMS 986020 | BB165375 | 50mg | $319.5 |
| More product size | |||
| Melting point | 174-180°C |
|---|---|
| Boiling point | 664.8±55.0 °C(Predicted) |
| Density | 1.309±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| pka | 4.19±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChIKey | GQBRZBHEPUQRPL-LJQANCHMSA-N |
| SMILES | C1(C2=CC=C(C3=CC=C(C4ON=C(C)C=4NC(O[C@@H](C4=CC=CC=C4)C)=O)C=C3)C=C2)(C(O)=O)CC1 |
| FDA UNII | 38CTP01B4L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
BMS-986020 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22049 | BMS 986020 ≥98% | 1257213-50-5 | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 22049 | BMS 986020 ≥98% | 1257213-50-5 | 1mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 22049 | BMS 986020 ≥98% | 1257213-50-5 | 5mg | $153 | 2024-03-01 | Buy |
| TRC | B701320 | BMS-986020 | 1257213-50-5 | 25mg | $185 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BB165375 | BMS 986020 | 1257213-50-5 | 50mg | $319.5 | 2021-12-16 | Buy |
BMS-986020 Chemical Properties,Uses,Production
Description
BMS 986020 is a potent G protein-coupled lysophosphatidic acid receptor 1 (LPA1) antagonist with an IC50 value less than 300 nM for human LPA1 expressing CHO cells. Formulations containing BMS 986020 are being investigated in clinical trials for efficacy in idiopathic pulmonary fibrosis.
Uses
BMS-986020 is an LPA-1 antagonist which may be used in the inhibition and treatment of bleomycin-induced pulminary fibrosis.
References
[1] PETER T. W. CHENG*. Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases[J]. Journal of Medicinal Chemistry, 2021, 64 21: 15549-15581. DOI: 10.1021/acs.jmedchem.1c01256
[2] VEERESA GUDUDURU . Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 2: Pages 451-456. DOI: 10.1016/j.bmcl.2005.08.096
[3] L. SIVARAMAN . Structure dependence and species sensitivity of in vivo hepatobiliary toxicity with lysophosphatidic acid receptor 1 (LPA1) antagonists[J]. Toxicology and applied pharmacology, 2022, 438: Article 115846. DOI: 10.1016/j.taap.2021.115846
[4] BHAKTA PRASAD GAIRE Ji W C Arjun Sapkota. BMS-986020, a Specific LPA1 Antagonist, Provides Neuroprotection against Ischemic Stroke in Mice.[J]. Antioxidants, 2020, 9 11. DOI: 10.3390/antiox9111097
BMS-986020 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39043 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
View Lastest Price from BMS-986020 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-05 | BMS-986020
1257213-50-5
|
US $47.00-122.00 / mg | 98.82% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-13 | BMS-986020
1257213-50-5
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co | |
 |
2020-01-13 | BMS-986020
1257213-50-5
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- BMS-986020
1257213-50-5
- US $47.00-122.00 / mg
- 98.82%
- TargetMol Chemicals Inc.
-
- BMS-986020
1257213-50-5
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co
-
- BMS-986020
1257213-50-5
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co
