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3-METHYLADENINE

3-METHYLADENINE structure

CAS No.: 5142-23-4

Chemical Name:: 3-METHYLADENINE

Synonyms: 109723;NSC 66389;NSC-63889;NSC 66389,3-M;3-Methyl-6-am;NSC 66389,3-MA;3-methyl-adenin;3-METHYLADENINE;N3-Methyladenine;Adenine, 3-methyl-

CBNumber:: CB9307216

Molecular Formula:: C6H7N5

Molecular Weight:: 149.15

MDL Number:: MFCD00010531

MOL File:: 5142-23-4.mol

Last updated:2026-03-12 18:10:29

Product description	Number	Pack Size	Price
Autophagy Inhibitor, 3-MA	189490	50mg	$155
Autophagy Inhibitor, 3-MA	189490	100mg	$171
3-Methyladenine	M2518	200mg	$141
3-Methyladenine	M2518	1g	$492
3-Methyladenine ≥95%	13242	25mg	$33
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3-METHYLADENINE Properties

Melting point	~300 °C (dec.)(lit.)
Boiling point	240℃
Density	1.60
refractive index	1.8070 (estimate)
Flash point	99℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
form	Powder
pka	6.77±0.20(Predicted)
color	White
biological source	synthetic (organic)
BRN	146087
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
InChI	InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3
InChIKey	FSASIHFSFGAIJM-UHFFFAOYSA-N
SMILES	N1C2C(N(C)C=NC=2N)=NC=1
EWG's Food Scores	1
FDA UNII	DR88TV7SNU
UNSPSC Code	41106305
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P403-P501c

Hazard Codes

Risk Statements

Safety Statements

24/25

WGK Germany

RTECS

AU6520000

HS Code

29335990

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

3-METHYLADENINE price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	189490	Autophagy Inhibitor, 3-MA	5142-23-4	50mg	$155	2025-07-31	Buy
Sigma-Aldrich	189490	Autophagy Inhibitor, 3-MA	5142-23-4	100mg	$171	2025-07-31	Buy
TCI Chemical	M2518	3-Methyladenine	5142-23-4	200mg	$141	2025-07-31	Buy
TCI Chemical	M2518	3-Methyladenine	5142-23-4	1g	$492	2025-07-31	Buy
Cayman Chemical	13242	3-Methyladenine ≥95%	5142-23-4	25mg	$33	2024-03-01	Buy

Product number	Packaging	Price	Buy
189490	50mg	$155	Buy
189490	100mg	$171	Buy
M2518	200mg	$141	Buy
M2518	1g	$492	Buy
13242	25mg	$33	Buy

3-METHYLADENINE Chemical Properties,Uses,Production

Description

Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.

Chemical Properties

White powder

Uses

3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.

Uses

A multi-use inhibitor that protects cerebellar granule cells from apoptosis.

Uses

A synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation

Definition

ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.

General Description

A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC₅₀ = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)

Biochem/physiol Actions

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).

storage

+4°C

References

[1] P O SEGLEN P B G. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1982, 79 6: 1889-1892. DOI:10.1073/pnas.79.6.1889
[2] EDWARD F. C. BLOMMAART. The Phosphatidylinositol 3-Kinase Inhibitors Wortmannin and LY294002 Inhibit Autophagy in Isolated Rat Hepatocytes[J]. The FEBS journal, 2004, 243 1-2: 240-246. DOI:10.1111/j.1432-1033.1997.0240a.x
[3] AMELIA J. MCFARLAND. Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity[J]. Archives of Toxicology, 2011, 86 2: 275-284. DOI:10.1007/s00204-011-0755-5
[4] X ZHAO. Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models.[J]. Current molecular medicine, 2014, 14 4: 555-563. DOI:10.2174/1566524014666140414211223

3-METHYLADENINE synthesis

Synthesis of 3-METHYLADENINE from Adenine-7-oxide

3-METHYLADENINE Preparation Products And Raw materials

Raw materials

Adenine Toluene Nickel Monoperoxyphthalic acid magnesium salt hexahydrate Benzyl bromide

N,N-Dimethylacetamide Sulfuric acid Dimethyl sulfate Adenosine, 2'-deoxy-,1-oxide (7CI,8CI,9CI) 3-Methyl Adenosine p-Toluenesulfonate Salt

Adenine-7-oxide 9-Methyladenine Iodomethane

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Preparation Products

1-METHYLADENINE

3-METHYLADENINE Suppliers

Global( 391)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8749	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8495	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20126	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 3-METHYLADENINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-12	3-Methyladenine 5142-23-4	US $48.00-266.00 / mg		98.00%	10g	TargetMol Chemicals Inc.
2026-03-06	3-METHYLADENINE 5142-23-4	US $10.00 / KG	1KG	99%	5tons	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	3-METHYLADENINE 5142-23-4	US $10.00-2.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

3-Methyladenine
5142-23-4
US $48.00-266.00 / mg
98.00%
TargetMol Chemicals Inc.

3-METHYLADENINE
5142-23-4
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

3-METHYLADENINE
5142-23-4
US $10.00-2.00 / KG
99%
Henan Fengda Chemical Co., Ltd

3-METHYLADENINE Spectrum

3-METHYLADENINE(5142-23-4)MS 3-METHYLADENINE(5142-23-4)¹HNMR 3-METHYLADENINE(5142-23-4)IR1 3-METHYLADENINE(5142-23-4)Raman

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3H-Purin-6-amine, 3-methyl- 3-methyl-3h-purin-6-amin 3-Methyl-3H-purin-6-amine 3-methyl-adenin Adenine, 3-methyl- 3-METHYLADENINE 3-methyl-3H-adenine 6-AMINO-3-METHYLPURINE Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem 109723 3-methylpurin-6-amine 3-Methyladenine, 90+%, pure 3-Methyladenine, pure 3-Methyl-6-amino-3H-purine 3-Methyladenine6-Amino-3-methylpurine 3-Methyladenine, pure, 90+% 3-Methyl-6-aminopurine N3-Methyladenine NSC 66389 3-MA (3-Methyl adenine) 3-methyladenine,3MA Autophagy Inhibitor, 3-MA NSC 66389,3-MA 3-Methyladenine, GC 90+% NSC 66389,3-M 6-Amino-3-methylpurine 3-Methyladenine Autophagy Inhibitor 3-Methyladenine, >=98% Methyladenine Methyladenine NSC-63889 3-METHYLADENINE USP/EP/BP N3-Methyladenine/NSC 66389 3-Methyl-6-am 3-Methyladenine, selective PI3K inhibitor 3-Methyladenine, 10 mM in DMSO 3-Methyl-3H-purin-6-ylamine 5142-23-4 12312312-89-6 Csub6subHsub7subNsub5sub Building Blocks Biochemicals and Reagents BioChemical Heterocyclic Building Blocks Purines Nucleoside Analogs Nucleosides, Nucleotides, Oligonucleotides Akt mTOR PI3K Amines Bases & Related Reagents Heterocycles Inhibitors Nucleotides