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2-Chloro-5-methyl-3-nitropyridine

2-Chloro-5-methyl-3-nitropyridine Structure
2-Chloro-5-methyl-3-nitropyridine structure
CAS No.
23056-40-8
Chemical Name:
2-Chloro-5-methyl-3-nitropyridine
Synonyms
6-CHLORO-5-NITRO-3-PICOLINE;2-CHLORO-3-NITRO-5-PICOLINE;2-Chloro-3-nitro-5-picoline,98%;2-chloro-5-methyl-3-nitropyridne;2-CHLORO-3-NITRO-5-METHYLPYRIDINE;2-CHLORO-5-METHYL-3-NITROPYRIDINE;2-Chloro-5-methyl-3-nitropyrinedi;2-Chloro-5-metnyl-3-nitropyridine;Pyridine, 2-chloro-5-Methyl-3-nitro-;2-Chloro-5-methyl-3-nitropyridine 97%
CBNumber:
CB9319455
Molecular Formula:
C6H5ClN2O2
Molecular Weight:
172.57
MDL Number:
MFCD02070020
MOL File:
23056-40-8.mol
Last updated:2026-01-13 11:27:06
Product description Number Pack Size Price
2-Chloro-5-methyl-3-nitropyridine 97% 705918 5g $90
2-Chloro-5-methyl-3-nitropyridine 97% 705918 1g $64.4
2-Chloro-5-methyl-3-nitropyridine >98.0%(GC) C2022 1g $38
2-Chloro-5-methyl-3-nitropyridine >98.0%(GC) C2022 5g $118
2-Chloro-5-methyl-3-nitropyridine C993775 10g $90
More product size
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2-Chloro-5-methyl-3-nitropyridine Properties

Melting point 45-50 °C
Boiling point 290.8±35.0 °C(Predicted)
Density 1.406±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -2.20±0.10(Predicted)
form powder to crystal
color White to Orange to Green
Sensitive Hygroscopic
BRN 138198
InChI 1S/C6H5ClN2O2/c1-4-2-5(9(10)11)6(7)8-3-4/h2-3H,1H3
InChIKey LUAJUWOJEFFNFE-UHFFFAOYSA-N
SMILES Cc1cnc(Cl)c(c1)[N+]([O-])=O
CAS DataBase Reference 23056-40-8(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H315-H318-H335
Precautionary statements  P280-P301+P310+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-21/22-41-37/38-22
Safety Statements  36/37/39-26-36-39
RIDADR  2811
WGK Germany  3
Hazard Note  Harmful
HazardClass  6.1
PackingGroup  III
HS Code  29333990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Chloro-5-methyl-3-nitropyridine price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 705918 2-Chloro-5-methyl-3-nitropyridine 97% 23056-40-8 5g $90 2023-06-20 Buy
Sigma-Aldrich 705918 2-Chloro-5-methyl-3-nitropyridine 97% 23056-40-8 1g $64.4 2023-01-07 Buy
TCI Chemical C2022 2-Chloro-5-methyl-3-nitropyridine >98.0%(GC) 23056-40-8 1g $38 2025-07-31 Buy
TCI Chemical C2022 2-Chloro-5-methyl-3-nitropyridine >98.0%(GC) 23056-40-8 5g $118 2025-07-31 Buy
TRC C993775 2-Chloro-5-methyl-3-nitropyridine 23056-40-8 10g $90 2021-12-16 Buy
Product number Packaging Price Buy
705918 5g $90 Buy
705918 1g $64.4 Buy
C2022 1g $38 Buy
C2022 5g $118 Buy
C993775 10g $90 Buy

2-Chloro-5-methyl-3-nitropyridine Chemical Properties,Uses,Production

Application

2-Chloro-5-methyl-3-nitropyridine is an organic intermediate that can be obtained by chlorination of 5-methyl-3-nitropyridine-2(1H)-one. The chlorination reagent can be selected from phosphorus oxychloride. It can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes.

Chemical Properties

Beige powder

Synthesis

2-Hydroxy-5-methyl-3-nitropyridine

7464-14-4

2-Chloro-5-methyl-3-nitropyridine

23056-40-8

a) General procedure for the synthesis of 2-chloro-5-methyl-3-nitropyridine: 5-methyl-3-nitropyridin-2-ol (5 g, 32.4 mmol) and benzyltrimethylammonium chloride (3.01 g, 16.2 mmol) were dissolved in acetonitrile, followed by addition of phosphorochloridic acid (9.0 ml, 97.2 mmol). The reaction mixture was stirred at 80 °C for 6 hours. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water to quench the reaction. The aqueous phase was extracted with dichloromethane and the organic layers were combined, washed with saturated brine solution and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using dichloromethane as eluent. The fraction containing the target compound was collected and concentrated under reduced pressure to give 2-chloro-5-methyl-3-nitropyridine as a yellow solid (5.39 g, 97% yield). The product was confirmed by 1H-NMR (CDCl3, 300 MHz) and mass spectrometry (ESI): 1H-NMR δ= 8.45 (d, 1H, J = 2.3Hz), 8.04 (d, 1H, J = 2.3Hz), 2.46 (s, 3H); MS (ESI) m/z: 173.0 ([M+H]+).

References

[1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 51
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995
[3] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 9
[4] Patent: WO2015/73528, 2015, A1. Location in patent: Page/Page column 118
[5] Journal of the American Chemical Society, 1951, vol. 73, p. 3504

2-Chloro-5-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine Calcium oxide Phosphorus oxitrichloride Sodium nitrite Diethyl ether
Nitric acid Sodium hydroxide Sulfuric acid 2-Hydroxy-5-methyl-3-nitropyridine trichlorophosphate

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Preparation Products

5-NITRONICOTINIC ACID 3-AMINO-2-CHLORO-5-PICOLINE 2-Methoxy-3-Nitro-5-Picoline

2-Chloro-5-methyl-3-nitropyridine Suppliers

Global( 291)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29833 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8830 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Antai Fine Chemical Technology Co.,Limited 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58

View Lastest Price from 2-Chloro-5-methyl-3-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-methyl-3-nitropyridine pictures 2025-12-01 2-Chloro-5-methyl-3-nitropyridine
23056-40-8
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Chloro-5-methyl-3-nitropyridine pictures 2025-11-18 2-Chloro-5-methyl-3-nitropyridine
23056-40-8
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Chloro-5-methyl-3-nitropyridine pictures 2025-09-25 2-Chloro-5-methyl-3-nitropyridine
23056-40-8
 US $5.00-0.10 / KG 1KG 98% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

2-Chloro-5-methyl-3-nitropyridine Spectrum

2-Chloro-5-methyl-3-nitropyridine(23056-40-8)MS2-Chloro-5-methyl-3-nitropyridine(23056-40-8)1HNMR2-Chloro-5-methyl-3-nitropyridine(23056-40-8)13CNMR2-Chloro-5-methyl-3-nitropyridine(23056-40-8)IR12-Chloro-5-methyl-3-nitropyridine(23056-40-8)IR2

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6-CHLORO-5-NITRO-3-PICOLINE 2-CHLORO-5-METHYL-3-NITROPYRIDINE 2-CHLORO-3-NITRO-5-METHYLPYRIDINE 2-CHLORO-3-NITRO-5-PICOLINE 2-Chloro-3,5-dimethyl-4-methoxypyridine 2-Chloro-5-methyl-3-nitropyridine 97% 2-CHLORO-3-NITRO-5-PICOLINE (2-CHLORO-5-METHYL-3-NITROPYRIDINE) 2-Chloro-3-nitro-5-picoline,98% Pyridine, 2-chloro-5-Methyl-3-nitro- 2-chloro-5-methyl-3-nitropyridne 2-Chloro-5-Methyl-3-nitropyridine, 97+% 2-Chloro-5-methyl-3-nitropyrinedi 2-Chloro-5-methyl-3-nitropyridine > 2-Chloro-5-methyl-3-nitropyridine ISO 9001：2015 REACH 2-Chloro-5-metnyl-3-nitropyridine 2-Chloro-5-methyl-3-nitropyridine, 95% 23056-40-8 Chloropyridines Halopyridines pyridine series Building Blocks C5 to C6 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Chloropyridines Halopyridines blocks NitroCompounds Pyridines Pyridine C6