ABT594 2HCL
- CAS No.
- 209326-19-2
- Chemical Name:
- ABT594 2HCL
- Synonyms
- ABT594 2HCL;Tebanicline dihydrochloride
- CBNumber:
- CB93339845
- Molecular Formula:
- C9H12Cl2N2O
- Molecular Weight:
- 235.11
- MDL Number:
- MFCD32693931
- MOL File:
- 209326-19-2.mol
- MSDS File:
- SDS
ABT594 2HCL price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6400 | Tebanicline (dihydrochloride) 99.49% | 209326-19-2 | 5mg | $117 | 2026-06-04 | Buy |
| ChemScene | CS-6400 | Tebanicline (dihydrochloride) 99.49% | 209326-19-2 | 10mg | $169 | 2026-06-04 | Buy |
| ChemScene | CS-6400 | Tebanicline (dihydrochloride) 99.49% | 209326-19-2 | 25mg | $325 | 2026-06-04 | Buy |
| ChemScene | CS-6400 | Tebanicline (dihydrochloride) 99.49% | 209326-19-2 | 50mg | $572 | 2026-06-04 | Buy |
| ChemScene | CS-6400 | Tebanicline (dihydrochloride) 99.49% | 209326-19-2 | 100mg | $962 | 2026-06-04 | Buy |
ABT594 2HCL Chemical Properties, Uses, Production
Uses
Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM[1].
in vivo
Tebanicline is a potent antinociceptive agent with full efficacy in models of acute and persistent pain and that these effects are mediated predominately by an action at central neuronal nAChRs[2]. Tebanicline produces significant antinociceptive effects in mice against both acute noxious thermal stimulation. ABT-594 is orally active, but 10-fold less potent by this route than after i.p. administration. The antinociceptive effect of ABT-594 is prevented, but not reversed, by the noncompetitive neuronal nicotinic acetylcholine receptor antagonist[3]. Tebanicline has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of tebanicline into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic tebanicline[4].
References
[1] Donnelly-Roberts DL, et al. ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.J Pharmacol Exp Ther. 1998 May;285(2):777-86. PMID:9580626
[2] Bannon AW, et al. ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization. J Pharmacol Exp Ther. 1998 May;285(2):787-94. PMID:9580627
[3] Decker MW, et al. Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice. Eur J Pharmacol. 1998 Apr 3;346(1):23-33. DOI:10.1016/s0014-2999(98)00042-9
[4] Decker MW, et al. The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594. J Physiol Paris. 1998 Jun-Aug;92(3-4):221-4. DOI:10.1016/s0928-4257(98)80014-4
ABT594 2HCL Preparation Products And Raw materials
Raw materials
Preparation Products
ABT594 2HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Latest Price from ABT594 2HCL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Tebanicline dihydrochloride
209326-19-2
|
$49.00 | 10g | TargetMol Chemicals Inc. |
-
- Tebanicline dihydrochloride
209326-19-2
- $49.00
- TargetMol Chemicals Inc.
