Antipyrinecarboxylic acid
- CAS No.
- 83-10-3
- Chemical Name:
- Antipyrinecarboxylic acid
- Synonyms
- 112688;NSC 59834;ANTIPYRIC ACID;RARECHEM AL BE 0663;Antipyrinecarboxylic acid;4-Antipyrinecarboxylic acid;1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolecarboxylic acid;1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxylic acid;1,5-dimethyl-3-oxo-2-phenyl-pyrazole-4-carboxylic acid;3-keto-1,5-dimethyl-2-phenyl-pyrazole-4-carboxylic acid
- CBNumber:
- CB9347243
- Molecular Formula:
- C12H12N2O3
- Molecular Weight:
- 232.24
- MDL Number:
- MFCD00020785
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H302-H335 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2933119000 |
Antipyrinecarboxylic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S366692 | ANTIPYRIC ACID AldrichCPR | 83-10-3 | 1 unit | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | S366692 | ANTIPYRIC ACID AldrichCPR | 83-10-3 | 1G | $179 | 2024-03-01 | Buy |
| Synthonix | D55723 | 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid 95+% | 83-10-3 | 100mg | $44 | 2026-05-06 | Buy |
| Synthonix | D55723 | 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid 95+% | 83-10-3 | 250mg | $48 | 2026-05-06 | Buy |
| Synthonix | D55723 | 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid 95+% | 83-10-3 | 1g | $50 | 2026-05-06 | Buy |
Antipyrinecarboxylic acid Chemical Properties, Uses, Production
Synthesis
950-81-2
83-10-3
The general procedure for the synthesis of 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid from 4-antipyrinecarboxaldehyde is as follows: 1. 1-benzyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxaldehyde (1 g, 4.624 mmol) was dissolved in butanol at 0 °C to prepare a mixture. 2. An aqueous solution of NaClO2 (1.254 g, 13.873 mmol) and an aqueous solution of potassium dihydrogen phosphate monohydrate (3.146 g, 23.12 mmol) were slowly added to the above mixture. 3. the reaction mixture was slowly heated to room temperature with continuous stirring for 10 hours. 4. During the reaction, NaClO3 (1 g) was further added and the progress of the reaction was monitored. 5. After addition of sodium chlorite, stirring of the reaction mixture was continued followed by extraction with ethyl acetate. 6. The organic layer was washed, dried with Na2SO4 and filtered. 7. The filtrate was concentrated under reduced pressure to give a residue. 8. The residue was washed with hexane solution of 20% ethyl acetate to afford the target compound 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid as a white solid (808 mg, 3.48 mmol, 75% yield). Product characterization data: 1H NMR (400 MHz, DMSO): δ 12.22 (br s, 1H), 7.61-7.42 (m, 5H), 3.36 (s, 3H), 2.59 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 1858 - 1867
[2] Patent: US2011/183983, 2011, A1. Location in patent: Page/Page column 20-21
[3] Pharmazie, 1956, vol. 11, p. 191,193
[4] Justus Liebigs Annalen der Chemie, 1949, vol. 563, p. 1,9
[5] Chemical and Pharmaceutical Bulletin, 1958, vol. 6, p. 374,376
Antipyrinecarboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-0371-55629727 13323845623 | 2885676761@qq.com | China | 9957 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Shanghai silk sail pharmaceutical technology co., LTD | 18916696128 | service@snowpharm.com | China | 1369 | 58 |
| Xinyi Kaiwu Chemical Technology Co., Ltd. | 0516-0516-88997009 18651776937 | 4164357@qq.com | China | 3204 | 58 |
| Xi'an Minze Pharmaceutical Technology Co., Ltd | 13981836672 | 2560370848@qq.com | China | 2807 | 58 |
| Changzhou Yinghao Technology Development Co., Ltd | 15151934985 | sales@yingsapharm.com | China | 5455 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
View Latest Price from Antipyrinecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | ANTIPYRINECARBOXYLIC ACID
83-10-3
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
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- ANTIPYRINECARBOXYLIC ACID
83-10-3
- $1.00
- 95-99%
- Career Henan Chemical Co
