ChemicalBook >> CAS DataBase List >>Protopine
Protopine
- CAS No.
- 130-86-9
- Chemical Name:
- Protopine
- Synonyms
- BIFLORIN;Protopin;PROTOPINE;Biflorine;Corydinine;Tangeratin;Hypercorine;AKOS 243-72;Corydalis C;Protopine-RM
- CBNumber:
- CB9347526
- Molecular Formula:
- C20H19NO5
- Molecular Weight:
- 353.37
- MDL Number:
- MFCD00022322
- MOL File:
- 130-86-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-04-22 18:57:36
| Product description | Number | Pack Size | Price |
| Protopine phyproof? Reference Substance | PHL89546 | 10mg | $466 |
| Protopine >98.0%(GC) | P2611 | 5mg | $36 |
| Protopine >98.0%(GC) | P2611 | 25mg | $104 |
| Protopine >98.0%(GC) | P2611 | 100mg | $286 |
| Protopine | 300834 | 20mg | $320 |
| More product size | |||
| Melting point | 203-205C |
|---|---|
| Boiling point | 486.8°C (rough estimate) |
| Density | 1.399 (calc) |
| refractive index | 1.5800 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| Water Solubility | Insoluble in water |
| solubility | DMSO : 12.5 mg/mL (35.37 mM; Need ultrasonic) |
| pka | 7.86±0.20(Predicted) |
| form | powder to crystal |
| color | White to Light gray to Light yellow |
| Major Application | food and beverages |
| InChI | InChI=1S/C20H22NO5/c1-25-11-23-17-5-4-13-2-3-14-9-19-18(24-12-26(19)22)8-15(14)6-7-21-10-16(13)20(17)25/h2-5,8,16,21H,6-7,9-12H2,1H3/b13-2-,14-3- |
| InChIKey | JVVZZYVMOGCQIP-JAIUMMMNSA-N |
| SMILES | N1CCC2=CC3OCO(=O)C=3CC2=CC=C2C=CC3OCO(C)C=3C2C1 |c:14,t:16| |
| LogP | 3.760 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | UIW569HT35 |
| NIST Chemistry Reference | Protopine(130-86-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| RTECS | VS2800000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29391900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Hazardous Substances Data | 130-86-9(Hazardous Substances Data) | |||||||||
| Toxicity | guinea pig,LD50,intraperitoneal,116mg/kg (116mg/kg),Therapie. Vol. 28, Pg. 767, 1973. | |||||||||
| NFPA 704 |
|
Protopine price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89546 | Protopine phyproof? Reference Substance | 130-86-9 | 10mg | $466 | 2026-03-19 | Buy |
| TCI Chemical | P2611 | Protopine >98.0%(GC) | 130-86-9 | 5mg | $36 | 2026-03-19 | Buy |
| TCI Chemical | P2611 | Protopine >98.0%(GC) | 130-86-9 | 25mg | $104 | 2026-03-19 | Buy |
| TCI Chemical | P2611 | Protopine >98.0%(GC) | 130-86-9 | 100mg | $286 | 2026-03-19 | Buy |
| Usbiological | 300834 | Protopine | 130-86-9 | 20mg | $320 | 2021-12-16 | Buy |
Protopine Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Protopine is a Ca2+ channel blocker and antiplatelet agent. Immunomodulator
Definition
ChEBI: A dibenzazecine alkaloid isolated from Fumaria vaillantii.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Purification Methods
It crystallises from EtOH/CHCl3. The picrate has m ~240o(dec). [Beilstein 27 H 558, 17 I 568, 17 II 620, 17 III/IV 6881.]
Protopine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 250)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
View Lastest Price from Protopine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Protopine
130-86-9
|
US $50.00 / mg | 99.25% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Protopine
130-86-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-13 | Protopine
130-86-9
|
US $90.00 / KG | 1KG | 99% | 100mt | Hebei baicao biology science and technology co., ltd |
130-86-9(Protopine)Related Search:
1of4
7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-
7-Methyl-6,8,9,16-tetrahydrodi[1,3]benzodioxolo[4,5-c:5,6-g]azecin-15(7H)-one
Biflorine
Bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-
Corydinine
Hypercorine
Protopin
BIFLORIN
AKOS 243-72
5,7-DIHYDROXY-2-METHYLCHROMONE-6-C-BETA-D-GLUCOPYRANOSIDE
PROTOPINE
4,6,7,14-Tetrahydro-5-methyl-bis[1,3]benzodioxolo[4,5-c-5',6'-g] azecin-13(5H)-one
7-Methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one
5-Methyl-9,10-(methylenedioxy)-4,6,7,13-tetrahydrobenzo[e]-1,3-dioxolo[4,5-l][2]benzazecine-12(5H)-one
6-Methyl-3,4-(methylenebisoxy)-10,11-(methylenebisoxy)-5,6,7,8-tetrahydrodibenzo[c,g]azecine-13(14H)-one
7-Methyl-6,7,8,9-tetrahydro-[1,3]dioxolo[4',5':5,6]benzo[1,2-c][1,3]dioxolo[5',4':4,5]benzo[1,2-g]azecin-15(16H)-one
4,6,7,14-Tetrahydro-5-Methyl-
Tangeratin
Corydalis C
Protopine (Corydinine)
Protopine, 98%, from Corydalis yanhusuo W. T. Wang ex Z. Y. Su et C. Y. Wu
Protopine USP/EP/BP
1H-Isoindole-1,3(2H)-dione,2-(3-butyn-2-yl)-
Protopine 100 μg/ml Acetonitrile
Protopine-RM
Protopine, 10 mM in DMSO
4,6,7,14-tetrahydro-5-methylbis[1,3]benzenebenzodioxypentylcyclobenzo[4,5-c:5',6'-g]azacyclodecylalkane-13(5H)-one
130-86-9
C20H19O5
chemical reagent
pharmaceutical intermediate
phytochemical
reference standards from Chinese medicinal herbs (TCM).
standardized herbal extract
Aromatics
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
