BRAZILIN
- CAS No.
- 474-07-7
- Chemical Name:
- BRAZILIN
- Synonyms
- razilin;BRAZILIN;CI 75280;brasilin;NSC 56652;braziletto;Brazilin-RM;(+)-Brazilin;Brazilin(6CI);superbresiline
- CBNumber:
- CB9350126
- Molecular Formula:
- C16H14O5
- Molecular Weight:
- 286.28
- MDL Number:
- MFCD00210817
- MOL File:
- 474-07-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Brazilin | SML2132 | 5MG | $184 |
| Brazilin | SML2132 | 25MG | $454 |
| Brazilin phyproof® Reference Substance | PHL83310 | 10 mg | $413 |
| Brazilin ≥98% | 22456 | 1mg | $36 |
| Brazilin ≥98% | 22456 | 5mg | $153 |
| More product size | |||
| Melting point | 156-157℃ |
|---|---|
| Boiling point | 348.65°C (rough estimate) |
| Density | 1.1924 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | 2-8°C |
| solubility |
DMSO:43.5(Max Conc. mg/mL);151.95(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);104.79(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);104.79(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);34.93(Max Conc. mM) |
| Colour Index | 75280 |
| form | A crystalline solid |
| color | Yellow to brown |
| optical activity | [α]/D 108.0 to 133.0°, c =0.5 in methanol |
| InChI | InChI=1S/C16H14O5/c17-9-1-2-10-14(4-9)21-7-16(20)6-8-3-12(18)13(19)5-11(8)15(10)16/h1-5,15,17-20H,6-7H2 |
| InChIKey | UWHUTZOCTZJUKC-UHFFFAOYSA-N |
| SMILES | C12C3C=CC(O)=CC=3OCC1(O)CC1=CC(O)=C(O)C=C21 |
| FDA UNII | FZ39SW1K10 |
| EPA Substance Registry System | Brazilin (474-07-7) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
BRAZILIN price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2132 | Brazilin | 474-07-7 | 5MG | $184 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2132 | Brazilin | 474-07-7 | 25MG | $454 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL83310 | Brazilin phyproof® Reference Substance | 474-07-7 | 10 mg | $413 | 2026-04-30 | Buy |
| Cayman Chemical | 22456 | Brazilin ≥98% | 474-07-7 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 22456 | Brazilin ≥98% | 474-07-7 | 5mg | $153 | 2026-04-30 | Buy |
BRAZILIN Chemical Properties,Uses,Production
Description
Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. Brazilin inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 μM) more potently than (-)-epigallocatechin gallate , cucurmin , and resveratrol (Item Nos. 10004235 | 70675). It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 and TNF-α (IC50s = 12.6 and 87.2 μM). It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 μg/ml. In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.
Chemical Properties
Sourced from Sumac, family Sumacaceae.
Uses
Brazilin is a hair dyeing composition that comprises a natural dye and fatty amine.
Uses
inhibits platelet aggregation, PLA2, PKC, protein phosphatase, insulin receptor kinase, nitric oxide synthase, antineoplastic
Uses
Chiefly as a dye. Has also been recommended as indicator in acid-base titrations; acids = yellow, alkalies = carmine-red.
Definition
ChEBI: A organic heterotetracyclic compound that is a red pigment obtained from the wood of Caesalpinia echinata (Brazil-wood) or Caesalpinia sappan (sappan-wood).
Purification Methods
Brazilin crystallises from EtOH as yellow crystals which become orange when exposed to light and air, and is yellow in dilute acid but crimson in dilute alkali. When crystallised from H2O, it has m 247-248o. It forms coloured metal salts and is oxidized in air to Brazilein the quinonoid form. The (±)-form has been resolved, and the (+)-enantiomer has [] 20 +121o (c 1, MeOH). [Craig et al. J Org Chem 30 1573 1965,Morsingh & Robinson Tetrahedron 26 281 1970, Beilstein 17 H 194, 17 II 244, 17 III/IV 2711.]
References
[1] HYUNJI LEE. Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes.[J]. PLoS ONE, 2015: e0136122. DOI: 10.1371/journal.pone.0136122
[2] WEN-JIE DU. Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity.[J]. Scientific Reports, 2015: 7992. DOI: 10.1038/srep07992
[3] SUPINYA TEWTRAKUL. Antiinflammatory and Wound Healing Effects of Caesalpinia sappan L.[J]. Phytotherapy Research, 2015, 29 6: 850-856. DOI: 10.1002/ptr.5321
[4] NILESH PRAKASH NIRMAL Pharkphoom P. Antioxidant, antibacterial, and anti-inflammatory activities of standardized brazilin-rich Caesalpinia sappan extract.[J]. Pharmaceutical Biology, 2015, 53 9: 1339-1343. DOI: 10.3109/13880209.2014.982295
[5] JINHEE KIM . Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action[J]. International immunopharmacology, 2015, 29 2: Pages 628-634. DOI: 10.1016/j.intimp.2015.09.018
BRAZILIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3590 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
View Lastest Price from BRAZILIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Brazilin
474-07-7
|
US $31.00-98.00 / mg | 98.20% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-12 | BRAZILIN
474-07-7
|
US $1.00-22.00 / KG | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-02-24 | Brazilin
474-07-7
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
