Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Ethyl 4-hydroxy-3-methoxycinnamate

Ethyl 4-hydroxy-3-methoxycinnamate

Ethyl 4-hydroxy-3-methoxycinnamate Structure
Ethyl 4-hydroxy-3-methoxycinnamate structure
CAS No.
4046-02-0
Chemical Name:
Ethyl 4-hydroxy-3-methoxycinnamate
Synonyms
ETHYL FERULATE;methoxycinnamate;FERULIC ACID ETHYL ESTER;ETHYL 4-HYDROXY-3-METHOXYCINNAMATE;Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate;FeruL;BBR 3222;NSC 14879;ethyl4-hydro;BUTTPARK 121\04-55
CBNumber:
CB9360604
Molecular Formula:
C12H14O4
Molecular Weight:
222.24
MDL Number:
MFCD00009190
MOL File:
4046-02-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 16:34:24
Product description Number Pack Size Price
Ethyl 4-hydroxy-3-methoxycinnamate 98% 320617 1g $104
Ethyl 4-hydroxy-3-methoxycinnamate 98% 320617 5g $226
Ethyl 4-Hydroxy-3-methoxycinnamate >97.0%(GC) E0739 5g $35
Ethyl 4-Hydroxy-3-methoxycinnamate >97.0%(GC) E0739 25g $139
Ferulic Acid ethyl ester ≥98% 11880 1g $61
More product size
Request For Quotation

Ethyl 4-hydroxy-3-methoxycinnamate Properties

Melting point 63-65 °C(lit.)
Boiling point 164-166 °C0.5 mm Hg(lit.)
Density 1.0643 (rough estimate)
refractive index 1.4560 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
pka 8.88±0.18(Predicted)
form Solid
color White to Off-White
Sensitive Light Sensitive
BRN 2696807
Stability Hygroscopic, Light Sensitive
Cosmetics Ingredients Functions ANTIOXIDANT
InChI 1S/C12H14O4/c1-3-16-12(14)7-5-9-4-6-10(13)11(8-9)15-2/h4-8,13H,3H2,1-2H3/b7-5+
InChIKey ATJVZXXHKSYELS-FNORWQNLSA-N
SMILES CCOC(=O)\C=C\c1ccc(O)c(OC)c1
LogP 1.940 (est)
CAS DataBase Reference 4046-02-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 5B8915UELW
NIST Chemistry Reference ethyl ferulate(4046-02-0)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-36
WGK Germany  3
Hazard Note  Irritant
HS Code  29189900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

Ethyl 4-hydroxy-3-methoxycinnamate price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 320617 Ethyl 4-hydroxy-3-methoxycinnamate 98% 4046-02-0 1g $104 2026-04-30 Buy
Sigma-Aldrich 320617 Ethyl 4-hydroxy-3-methoxycinnamate 98% 4046-02-0 5g $226 2026-04-30 Buy
TCI Chemical E0739 Ethyl 4-Hydroxy-3-methoxycinnamate >97.0%(GC) 4046-02-0 5g $35 2026-04-30 Buy
TCI Chemical E0739 Ethyl 4-Hydroxy-3-methoxycinnamate >97.0%(GC) 4046-02-0 25g $139 2026-04-30 Buy
Cayman Chemical 11880 Ferulic Acid ethyl ester ≥98% 4046-02-0 1g $61 2026-04-30 Buy
Product number Packaging Price Buy
320617 1g $104 Buy
320617 5g $226 Buy
E0739 5g $35 Buy
E0739 25g $139 Buy
11880 1g $61 Buy

Ethyl 4-hydroxy-3-methoxycinnamate Chemical Properties,Uses,Production

Description

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide. Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Ligusticum chuanxiong Hort.

Uses

Ferulic acid ethyl ester is an ethyl ester derivative of Ferulic acid (F308900), which is used as an antioxidant and food preservative.

Synthesis

To an ice-chilled suspension of trans-ferulic acid (1.942 g, 10 mmol, 1 eq) in absolute ethanol (20 mL) was added thionyl chloride (0.87 mL, 12 mmol, 1.2 eq). The resulting mixture was refluxed with stirring for 20 h. The solution was concentrated in vacuo, dissolved in ethyl acetate (30 mL) and washed with a 1 M HCI solution (15 mL), saturated NaHCOs solution (15 mL) and brine (15 mL). The organic layer was dried over anhydrous NajSC and concentrated in vacuo to afford Ethyl 4-hydroxy-3-methoxycinnamate as an orange oil (2.185 g, yield: 98%).
Ethyl 4'-hydroxy-3'-methoxycinnamate

References

[1] Organic and Biomolecular Chemistry, 2010, vol. 8, # 22, p. 5199 - 5211
[2] Tetrahedron Letters, 2014, vol. 55, # 32, p. 4427 - 4429
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 23, p. 7732 - 7752
[4] Patent: US2008/153878, 2008, A1. Location in patent: Page/Page column 17; 24
[5] Molecules, 2011, vol. 16, # 5, p. 3580 - 3596

Ethyl 4-hydroxy-3-methoxycinnamate Preparation Products And Raw materials

Raw materials

Vanillin Ethyl (triphenylphosphoranylidene)acetate

Preparation Products

(E)-3-(4-Ethoxy-3-methoxyphenyl)propenoic acid ethyl ester

Ethyl 4-hydroxy-3-methoxycinnamate Suppliers

Global( 538)Suppliers
Supplier Tel Email Country ProdList Advantage
BINBO BIOLOGICAL CO.,LTD
+8618629063126 info@binbobiological.com China 477 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656 1059@dideu.com China 3589 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9333 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +8615350851019 admin@86-ss.com China 999 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21588 55
Supplier Advantage
BINBO BIOLOGICAL CO.,LTD
58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Henan Aochuang Chemical Co.,Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55

Related articles

View Lastest Price from Ethyl 4-hydroxy-3-methoxycinnamate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 4-hydroxy-3-methoxycinnamate pictures 2026-05-21 Ethyl 4-hydroxy-3-methoxycinnamate
4046-02-0
 US $500.00-300.00 / kg 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Ethyl 4'-hydroxy-3'-methoxycinnamate pictures 2026-05-19 Ethyl 4'-hydroxy-3'-methoxycinnamate
4046-02-0
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Ethyl ferulate pictures 2026-04-24 Ethyl ferulate
4046-02-0
 US $32.00 / mL 99.91% 10g TargetMol Chemicals Inc.

Ethyl 4-hydroxy-3-methoxycinnamate Spectrum

Ethyl 4'-hydroxy-3'-methoxycinnamate(4046-02-0)1HNMREthyl 4'-hydroxy-3'-methoxycinnamate(4046-02-0)FT-IREthyl 4'-hydroxy-3'-methoxycinnamate(4046-02-0)IREthyl 4'-hydroxy-3'-methoxycinnamate(4046-02-0)Raman

4046-02-0(Ethyl 4-hydroxy-3-methoxycinnamate)Related Search:

Ethyl acetate Ferulic Acid Cinnamic acid ISOXADIFEN-ETHYL Ethyl pyruvate
Ethyl formate Sodium ferulic 2-Ethylhexyl ferulate Ethyl acrylate Octyl 4-methoxycinnamate
Ethyl oleate Ethyl glycolate Ethyl cinnamate Ethyl 4-methylcinnamate Ethyl cyanoacetate
Ethylparaben 4-Hydroxycinnamic acid Ethanol

1of4

ETHYL 4-HYDROXY-3-METHOXYCINNAMATE Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate ETHYL TRANS-3-(4'-HYDROXY-3'-METHOXYPHENYL)ACRYLATE BUTTPARK 121\04-55 4-HYDROXY-3-METHOXYCINNAMIC ACID ETHYL ESTER RARECHEM AL BI 0735 Ethyl ferulate~Ferulic acid ethyl ester~4-Hydroxy-3-methoxycinnamic acid ethyl ester (E)-3-(4-HYDROXY-3-METHOXY-PHENYL)-ACRYLIC ACID ETHYL ESTER Ferulic acid ethyl eser ETHYL 4-HYDROXY-3-METHOXYCINNAMATE (FERULIC ACID ETHYL ESTER) erulic acid ethylester ethyl4-hydro (E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid ethyl ester ethyl Ferulic acid 4-Hydroxy-3-methoxycinnamic Acid Ethyl Ester Ethyl Ferulate Ferulic Acid Ethyl Ester cis-3-(4-Hydroxy-3-Methoxyphenyl)-2-propensaeure-ethylester BBR 3222 NSC 14879 (E)-ethyl 3-(4-hydroxy-3-Methoxyphenyl)acrylate Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate, Ethyl ferulate, Ethyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate 3-(3-Methoxy-4-hydroxyphenyl)propenoic acid ethyl ester 3-(4-Hydroxy-3-methoxyphenyl)propenoic acid ethyl ester FERULIC ACID ETHYLESTER(RG) Ethyl 4-hydroxy-3-methoxycinnamate,Ethyl ferulate Ethyl 4-hydroxy-3-methoxyciamate hyl 4'-hydroxy-3'-MethoxycinnaMate Ethyl4-Hydroxy-3-methoxycinnamate> FeruL 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, ethyl ester ETHYL FERULATE CAS 4046-02-0 methoxycinnamate ethyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate thyl 4'-hydroxy-3'-methoxycinnamate Natural Ethyl Ferulate Ethyl 4'-hydroxy-3'-methoxycinnamate Ethyl 4'-hydroxy-3'-methoxycinnamate|||Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate|||Ferulic acid ethyl ester Ethyl ferulate - Natural grade Ferulic Acid Impurity 31 (Mixture of E/Z-isomers) ETHYL FERULATE FERULIC ACID ETHYL ESTER 4046-02-0 046-02-0 4076-02-0 C12H14O4 C12H15O4 HOC6H3OCH3CHCHCO2C2H5 Esters Organic Building Blocks C12 to C63 Carbonyl Compounds Building Blocks Building Blocks C12 to C63 Carbonyl Compounds Chemical Synthesis Esters Organic Building Blocks Inhibitors