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Scopolamine hydrobromide

Scopolamine hydrobromide Structure
Scopolamine hydrobromide structure
CAS No.
114-49-8
Chemical Name:
Scopolamine hydrobromide
Synonyms
HYOSCINE;HYOSCINE HYDROBROMIDE;triptone;SCOPOLAMINE HBR;Scopolamine Hydrobromide Powder;Scopolamine Hydrobromide Hydrate;SCOPOLAMINE HCL;ScopolaMine HBr Trihydrate;hysco;Hyosol
CBNumber:
CB9363236
Molecular Formula:
C17H21NO4.BrH
Molecular Weight:
384.26
MDL Number:
MFCD00012647
MOL File:
114-49-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:50:02
Product description Number Pack Size Price
SCOPOLAMINE HYDROBROMIDE HYDRATE AldrichCPR R427039 1 unit $197
Hyoscine hydrobromide European Pharmacopoeia (EP) Reference Standard H1500000 50 mg $167
Scopolamine Hydrobromide - CAS 114-49-8 - Calbiochem 5.05818 1G $119
Scopolamine (hydrobromide) ≥95% 14108 1mg $90
Scopolamine (hydrobromide) ≥95% 14108 5mg $391
More product size
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Scopolamine hydrobromide Properties

Melting point 195-199 °C (dry matter)(lit.)
alpha D25 -24 to -26° (c = 5, calculated on anhydrous basis)
storage temp. Store at RT
solubility H2O: 50 mg/mL
form powder
color white to off-white
Water Solubility H2O: 100mM
Major Application forensics and toxicology
InChI InChI=1/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/s3
InChIKey WTGQALLALWYDJH-MLRWSLNSNA-N
SMILES [C@]12([H])O[C@@]1([H])[C@@]1([H])N(C)[C@]2([H])C[C@@H](OC(=O)[C@H](CO)C2C=CC=CC=2)C1.Br |&1:0,3,5,9,12,16,r|
CAS DataBase Reference 114-49-8(CAS DataBase Reference)
FDA UNII R3K67DRL3J
EPA Substance Registry System Scopolamine hydrobromide (114-49-8)
UNSPSC Code 41116107
NACRES NA.77

Pharmacokinetic data

Protein binding 10%
Excreted unchanged in urine 2 (1 - oral, 34 - transdermal)
Biological half-life 8 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS  YM4550000
F  3-8
TSCA  TSCA listed
HS Code  2939800000
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
Toxicity LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick)
REACH Registrations Inactive
NFPA 704
0
4 0

Scopolamine hydrobromide price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R427039 SCOPOLAMINE HYDROBROMIDE HYDRATE AldrichCPR 1 unit $197 2026-04-30 Buy
Sigma-Aldrich H1500000 Hyoscine hydrobromide European Pharmacopoeia (EP) Reference Standard 50 mg $167 2026-04-30 Buy
Sigma-Aldrich 5.05818 Scopolamine Hydrobromide - CAS 114-49-8 - Calbiochem 114-49-8 1G $119 2026-04-30 Buy
Cayman Chemical 14108 Scopolamine (hydrobromide) ≥95% 114-49-8 1mg $90 2026-04-30 Buy
Cayman Chemical 14108 Scopolamine (hydrobromide) ≥95% 114-49-8 5mg $391 2026-04-30 Buy
Product number Packaging Price Buy
R427039 1 unit $197 Buy
H1500000 50 mg $167 Buy
5.05818 1G $119 Buy
14108 1mg $90 Buy
14108 5mg $391 Buy

Scopolamine hydrobromide Chemical Properties,Uses,Production

Description

Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.

Chemical Properties

Off-White Solid

Uses

An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant

Definition

ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.

brand name

Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

General Description

Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.
Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.

General Description

Colorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.

Air & Water Reactions

Sensitive to air, light and moisture. Water soluble.

Reactivity Profile

Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .

Fire Hazard

Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.

Biological Activity

Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

Clinical Use

A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.

Metabolism

Hyoscine hydrobromide is almost entirely metabolised, probably in the liver; only a small proportion of an oral dose is excreted unchanged in the urine. In one study in man, 3.4% of a single dose, administered by subcutaneous injection was excreted unchanged in urine within 72 hours.

storage

Store at RT

Purification Methods

The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]

References

[1] JRG ZIEGLER  Peter J F. Alkaloid biosynthesis: metabolism and trafficking.[J]. Annual review of plant biology, 2008, 59: 735-769. DOI: 10.1146/annurev.arplant.59.032607.092730
[2] S WOODS. 5-HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms[J]. British Journal of Pharmacology, 2012, 167 2: 436-449. DOI: 10.1111/j.1476-5381.2012.02022.x
[3] ENRIQUE SOTO  Rosario V. Neuropharmacology of vestibular system disorders.[J]. Current Neuropharmacology, 2010, 8 1: 26-40. DOI: 10.2174/157015910790909511
[4] H E SHANNON. Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 290 2: 901-907.

Scopolamine hydrobromide Preparation Products And Raw materials

Raw materials

Nisin COREOPSISYELLOWEXTRACT

Preparation Products

Scopine N-Ethylnorhyoscine Hydrochloride

Scopolamine hydrobromide Suppliers

Global( 477)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3992 58
Guangzhou Tengyue Chemical Co., Ltd. 		+86-86-18148706580 +8618826483838 evan@tyvovo.com China 143 58
ARCTIC EXPORTS INC 		+1-3026880818 +1-3026880818; ARCTICEXPORTSINC@GMAIL.COM Canada 70 58
Shaanxi Xianhe Biotech Co., Ltd 		+86-17709210191; +8617709210191 Jerry@xhobio.com China 906 58
Wuhan JiyunZen Tech Co., Ltd. 		+86-18062099985 Amyjiyunzen@yeah.net China 672 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +8618080483897 sales@biopurify.com China 4616 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Shanghai Standard Technology Co., Ltd. 		18502101150 ft-sales@nature-standard.com CHINA 1923 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018 ramyan@ex-biotech.com CHINA 954 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Guangzhou Tengyue Chemical Co., Ltd. 		58
ARCTIC EXPORTS INC 		58
Shaanxi Xianhe Biotech Co., Ltd 		58
Wuhan JiyunZen Tech Co., Ltd. 		58
career henan chemical co 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Shandong chuangyingchemical Co., Ltd. 		58
Shanghai Standard Technology Co., Ltd. 		58
Shenzhen Excellent Biotech Co., Ltd. 		58

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Scopolamine hydrobromide Spectrum

Scopolamine hydrobromide(114-49-8)MSScopolamine hydrobromide(114-49-8)1HNMRScopolamine hydrobromide(114-49-8)13CNMRScopolamine hydrobromide(114-49-8)IR1Scopolamine hydrobromide(114-49-8)IR2

114-49-8(Scopolamine hydrobromide)Related Search:

SCOPOLAMINE N-OXIDE HYDROBROMIDE Scopolamine Hydrobromide Trihydrate Scopolamine Pyridine hydrobromide Scopolamine butylbromide
(-)-SCOPOLAMINE HYOSCINE HYDROCHLORIDE Scopine DL-(SCOPOLAMINE HYDROBROMIDE) Cimetropium bromide
DEXTROMETHORPHAN HYDROBROMIDE HYOSCINE N BUTYL BROMIDE BP Methscopolamine bromide Tropic acid Scopoletin
Hydrogen bromide DL-TROPIC ACID SCOPOLAMINE-D3 HBR 3H2O (N-METHYL-D3) Hyoscine Hydrobromide

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Benzeneacetic acid, a-(hydroxyMethyl)-, (1a,2b,4b,5a,7b)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobroMide (1:1), (aS)- ScopolaMine HBr Trihydrate ScopolaMine-d3 HBr 3H2O Hyosol Tranaxine Benzeneacetic acid, α-(hydroxymethyl)-, (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide (1:1), (αS)- Hyoscine HydrobroMide Trihydrate, (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester HydrobroMide Trihydrate SCOPOLAMINE HYDROBROMIDE SCOPOLOAMINE HYDROBROMIDE SCOPINE TROPATE HYDROBROMIDE (α,S)-α-(Hydroxymethyl)benzeneaceticacid(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylesterhydrobromide ()-Scopolamine hydrobromide trihydrate,Hyoscine hydrobromide, Scopine tropate (-)-scopolaminebromide ),hydrobromide scopolamine hydrobromide (anhydrous) Benzeneacetic acid, a-(hydroxymethyl)-, (1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide, (aS)- (alpha,S)-alpha-(Hydroxymethyl)benzeneacetic acid (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2.4)]non-7-yl ester hydrobromide (2S,3S,4S,5S)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol Scopolamine hydrobromide, 98%, from Datura metel L. (aS)-a-(Hydroxymethyl)benzeneacetic Acid (1a,2,4,5a,7)-9-(Methyl-d3)-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester Scopolammonium-d3 Bromide Scopolamine hydrobromide，Hyoscine hydrobromide Scopolaminehydrobromidetrihydra (αS)-α-(hydroxymethyl)-benzeneacetic acid-(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester (?)-Scopolamine hydrobromide hydrate (1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.02,4]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate hydrobromide (1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.0^{2,4}]nonan-7-yl- (2S)-3-hydroxy-2-phenylpropano .alpha.-(hydroxymethyl)-,9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester,hydrobromide,[7(Benzeneaceticacid 02,4]non-7-ylester,hydrobromide,[7(s)-(1alpha,2beta,4beta,5alpha,7beta) hyoscyinehydrobromide hysco isoscopil kwells l-hyoscinehydrobromide scopamin scopolaminebromide scopolaminiumbromide scopolammoniumbromide scopos sereen ATROSCINE HYDROBROMIDE (A,S)-ALPHA-(HYDROXYMETHYL)BENZENEACETIC ACID (1A,2B,4B,5A,7B)-9-METHYL-3-OXA-9-AZATRICYCLO[3.3.1.02,4]NON-7-YL ESTER HYDROBROMIDE HYOSCINE HBR HYOSCINE Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, (.alpha.S)- HYOSCINEHYDROBROMIDE(ANHYDROUS) SCOPOLAMINE HBR(RG) SCOPOLETIN(AHP) SCOPOLETIN(SH) 1aH,5aH-Tropan-3a-ol, 6b,7b-epoxy-, (-)-tropate (ester), hydrobromide (8CI) Benzeneacetic acid, a-(hydroxymethyl)-, (1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide, (aS)- (9CI) Benzeneacetic acid, a-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide, [7(S)-(1a,2b,4b,5a,7b)]- l-Scopolamine hydrobromide Wellcome Brand Scopolamine hydrobromide Injection (-)-SCOPOLAMINE HYDROBROMIDE CHOLINERGIC RECEPTOR SCOPOLAMINE HYDROBROMIDE, USP STANDARD Scopolamine hydrobromide, 99.0% (aS)-a-(Hydroxymethyl)benzeneacetic Acid (1a,2,4,5a,7)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester Hydrobromide Trihydrate