alpha-Bromo-p-toluenesulphonyl chloride
- CAS No.
- 66176-39-4
- Chemical Name:
- alpha-Bromo-p-toluenesulphonyl chloride
- Synonyms
- BUTTPARK 94\04-08;4-Bromomethylbenzenesulfonyl c;4-(Chlorosulphonyl)benzyl bromide;α-bromo-p-toluenesulfonyl chloride;à-bromo-p-toluenesulfonyl chloride;alpha-Bromo-p-toluenesulfonylchloride;ALPHA-BROMO-P-TOLUENESULPHONYL CHLORIDE;4-(BROMOMETHYL)BENZENESULFONYL CHLORIDE;4-bromo methy benzene sulfonyl chloride;4-(BROMOMETHYL)BENZENESULPHONYL CHLORIDE
- CBNumber:
- CB9364844
- Molecular Formula:
- C7H6BrClO2S
- Molecular Weight:
- 269.54
- MDL Number:
- MFCD00156129
- MOL File:
- 66176-39-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-(Bromomethyl)benzenesulfonyl chloride 95% | 557153 | 5g | $110 |
| 4-(Bromomethyl)benzenesulfonyl chloride 95% | 557153 | 1g | $34.8 |
| 4-(Bromomethyl)benzenesulfonyl Chloride >95.0%(GC)(T) | B3936 | 1g | $51 |
| 4-(Bromomethyl)benzenesulfonyl Chloride >95.0%(GC)(T) | B3936 | 5g | $153 |
| α-Bromo-p-toluenesulfonylChloride | B688250 | 100g | $1265 |
| More product size | |||
| Melting point | 71-75 °C(lit.) |
|---|---|
| Boiling point | 160-170 °C |
| Density | 1.6944 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Crystalline Powder |
| color | Off-white to light yellow |
| Sensitive | Moisture Sensitive |
| BRN | 2364328 |
| InChI | 1S/C7H6BrClO2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5H2 |
| InChIKey | QXTQWYZHHMQSQH-UHFFFAOYSA-N |
| SMILES | ClS(=O)(=O)c1ccc(CBr)cc1 |
| CAS DataBase Reference | 66176-39-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| NFPA 704 |
|
alpha-Bromo-p-toluenesulphonyl chloride price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 557153 | 4-(Bromomethyl)benzenesulfonyl chloride 95% | 66176-39-4 | 5g | $110 | 2025-07-31 | Buy |
| Sigma-Aldrich | 557153 | 4-(Bromomethyl)benzenesulfonyl chloride 95% | 66176-39-4 | 1g | $34.8 | 2023-06-20 | Buy |
| TCI Chemical | B3936 | 4-(Bromomethyl)benzenesulfonyl Chloride >95.0%(GC)(T) | 66176-39-4 | 1g | $51 | 2025-07-31 | Buy |
| TCI Chemical | B3936 | 4-(Bromomethyl)benzenesulfonyl Chloride >95.0%(GC)(T) | 66176-39-4 | 5g | $153 | 2025-07-31 | Buy |
| TRC | B688250 | α-Bromo-p-toluenesulfonylChloride | 66176-39-4 | 100g | $1265 | 2021-12-16 | Buy |
alpha-Bromo-p-toluenesulphonyl chloride Chemical Properties,Uses,Production
Chemical Properties
off-white to light yellow crystalline powder
Uses
4-(Bromomethyl)benzenesulfonyl chloride may be used to synthesize:
- 4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide
- benzene-sulfonamide derivatives, which are potent Chemokine Receptor Type 4 (CXCR4) inhibitors
- imidazole derivatives having antifungal activity
Synthesis
98-59-9
66176-39-4
General procedure for the synthesis of 4-bromomethylbenzenesulfonyl chloride from p-toluenesulfonyl chloride: to a stirred solution of p-toluenesulfonyl chloride (20 g, 104.9 mmol) in carbon tetrachloride (500 mL) was added sequentially N-bromosuccinimide (20.6 g, 115.7 mmol) and benzoyl peroxide (2.54 g, 10.84 mmol) at room temperature. The reaction mixture was refluxed for 10 hours and then filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to give a yellow oil. The oily substance was recrystallized using hexane as eluent to give 4-bromomethylbenzenesulfonyl chloride (20.6 g, 65% yield) as a final white solid.
References
[1] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 5, p. 1487 - 1493
[2] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4197 - 4204
[3] Journal of the American Chemical Society, 1957, vol. 79, p. 4232
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 9, p. 2437 - 2451
[5] Patent: US5318980, 1994, A
alpha-Bromo-p-toluenesulphonyl chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20128 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29833 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from alpha-Bromo-p-toluenesulphonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | alpha-Bromo-p-toluenesulphonyl chloride
66176-39-4
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2019-08-06 | alpha-Bromo-p-toluenesulphonyl chloride
66176-39-4
|
US $1.00 / KG | 1KG | 95-99% | 100kg/week | Career Henan Chemical Co |
-
- alpha-Bromo-p-toluenesulphonyl chloride
66176-39-4
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- alpha-Bromo-p-toluenesulphonyl chloride
66176-39-4
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co
