CALCIMYCIN A23187 HEMIMAGNESIUM SALT
- CAS No.
- 72124-77-7
- Chemical Name:
- CALCIMYCIN A23187 HEMIMAGNESIUM SALT
- Synonyms
- Calcimycin hemimagnesium;a23187hemimagnesium salt;CALCIMYCIN HEMIMAGNESIUM SALT;CALCIMYCIN A23187 HEMIMAGNESIUM SALT;calcium ionophore A23187 hemimagnesium;CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT;CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT BIOCHEMIKA;A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt
- CBNumber:
- CB9367461
- Molecular Formula:
- C58H72MgN6O12
- Molecular Weight:
- 1069.55
- MDL Number:
- MFCD00151203
- MOL File:
- 72124-77-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Calcium Ionophore A23187 hemimagnesium salt | C9400 | 5mg | $424 |
| Calcium Ionophore A23187 hemimagnesium salt | C9400 | 10mg | $687 |
| Calcimycin(hemimagnesium) | CS-0129636 | 1mg | $260 |
| Calcimycin(hemimagnesium) | CS-0129636 | 5mg | $720 |
| CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT 95.00% | API0007831 | 5MG | $854.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| F | 8 |
CALCIMYCIN A23187 HEMIMAGNESIUM SALT price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C9400 | Calcium Ionophore A23187 hemimagnesium salt | 72124-77-7 | 5mg | $424 | 2026-04-30 | Buy |
| Sigma-Aldrich | C9400 | Calcium Ionophore A23187 hemimagnesium salt | 72124-77-7 | 10mg | $687 | 2023-06-20 | Buy |
| ChemScene | CS-0129636 | Calcimycin(hemimagnesium) | 72124-77-7 | 1mg | $260 | 2021-12-16 | Buy |
| ChemScene | CS-0129636 | Calcimycin(hemimagnesium) | 72124-77-7 | 5mg | $720 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007831 | CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT 95.00% | 72124-77-7 | 5MG | $854.41 | 2021-12-16 | Buy |
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Chemical Properties,Uses,Production
Uses
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4].
in vivo
Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].
| Animal Model: | Mice (ICR, 25-30 g)[5] |
| Dosage: | 2.5 or 7.5 nM |
| Administration: | Intrapleurally |
| Result: | Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values. |
References
[1] Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82. DOI:10.1128/AAC.01130-10
[2] Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94. DOI:10.1038/sj.embor.embor722
[3] Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90. DOI:10.4161/auto.25900
[4] Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200. DOI:10.1016/j.bbagen.2017.09.010
[5] Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):90-5. DOI:10.1007/BF00180016
