3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
- CAS No.
- 306936-57-2
- Chemical Name:
- 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
- Synonyms
- AKOS B000254;AKOS PAO-0297;ART-CHEM-BB B000254;CHEMBRDG-BB 4301174;3-(4-FLUOROPHENYL)PYRAZOLE-4-CARBOXALDEHYDE;3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE;3-(4-fluorophenyl)-2H-pyrazole-4-carbaldehyde;3-(p-Fluorophenyl)-1H-pyrazole-4-carbaldehyde;3-(4-fluoropropyl) -1H-pyrazol-4-formaldehyde;Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-
- CBNumber:
- CB9396160
- Molecular Formula:
- C10H7FN2O
- Molecular Weight:
- 190.17
- MDL Number:
- MFCD01922131
- MOL File:
- 306936-57-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde 97% | 683272 | 1g | $85 |
| 3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde >98.0%(GC) | F1118 | 1g | $116 |
| 3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde >98.0%(GC) | F1118 | 5g | $352 |
| 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde Asreported | 277952 | 500mg | $333 |
| 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde Asreported | 277952 | 1g | $483 |
| More product size | |||
| Melting point | 160 °C |
|---|---|
| Boiling point | 416.0±35.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C, stored under nitrogen |
| pka | 10.69±0.50(Predicted) |
| form | powder to crystal |
| color | White to Orange to Green |
| Sensitive | Air Sensitive |
| InChI | 1S/C10H7FN2O/c11-9-3-1-7(2-4-9)10-8(6-14)5-12-13-10/h1-6H,(H,12,13) |
| InChIKey | CMXTUUXWJBLVEH-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1)-c2n[nH]cc2C=O |
| CAS DataBase Reference | 306936-57-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29331990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 683272 | 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde 97% | 306936-57-2 | 1g | $85 | 2023-06-20 | Buy |
| TCI Chemical | F1118 | 3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde >98.0%(GC) | 306936-57-2 | 1g | $116 | 2026-04-30 | Buy |
| TCI Chemical | F1118 | 3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde >98.0%(GC) | 306936-57-2 | 5g | $352 | 2026-04-30 | Buy |
| Usbiological | 277952 | 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde Asreported | 306936-57-2 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 277952 | 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde Asreported | 306936-57-2 | 1g | $483 | 2026-06-03 | Buy |
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Chemical Properties,Uses,Production
Chemical Properties
White to yellow-orange solid
Synthesis
326-33-0
68-12-2
306936-57-2
General procedure for the synthesis of 3-(4-fluoropropyl)-1H-pyrazole-4-carbaldehyde from 2-(1-(4-fluorophenyl)ethylidene)hydrazine-1-carboxamide and N,N-dimethylformamide: Phosphorochloride (2.1 mL, 23 mmol) was slowly added dropwise to N,N-dimethylformamide (4.4 mL, 57 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min, then brought to room temperature and continued stirring for 30 min. Subsequently, the reaction mixture was cooled in an ice/water bath and 2-(1-(4-fluorophenyl)ethylidene)hydrazine-1-carboxamide (1.96 g, 10 mmol) was slowly added, controlling the temperature not to exceed 50 °C. After the addition was completed, the reaction system was heated to 80 °C and stirred at this temperature for 2 hours. After completion of the reaction, the mixture was poured into ice (15 g) and the pH was adjusted to 10 with 5N NaOH solution and stirred for 2 hours. Subsequently, the reaction solution was acidified with concentrated hydrochloric acid and stirring was continued for 4 hours. The precipitated solid was collected by filtration, washed with a small amount of water and dried under high vacuum to give the target product 3-(4-fluoropropyl)-1H-pyrazole-4-carbaldehyde (1.5 g, 79% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 18, p. 4932 - 4935
[2] Russian Journal of General Chemistry, 2005, vol. 75, # 5, p. 782 - 789
[3] Patent: WO2013/22766, 2013, A1. Location in patent: Page/Page column 87
[4] European Journal of Medicinal Chemistry, 2017, vol. 133, p. 36 - 49
[5] Journal of Fluorine Chemistry, 2016, vol. 183, p. 59 - 68
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
View Lastest Price from 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
306936-57-2
|
$1.00 | 1kg | 98% | 200KG | Career Henan Chemical Co |
-
- 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
306936-57-2
- $1.00
- 98%
- Career Henan Chemical Co
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