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ChemicalBook >> CAS DataBase List >>EC 2.7.1.40

EC 2.7.1.40

EC 2.7.1.40 Structure
EC 2.7.1.40 structure
CAS No.
9001-59-6
Chemical Name:
EC 2.7.1.40
Synonyms
PK;PYRUVATE KINASE;HCCS4;SFMMP;MLTKbeta;MLTKalpha;EC 2.7.1.40;pyruvic kinase;PK （rabbit muscle);Pyruvate Kinase M2
CBNumber:
CB9396847
Molecular Formula:
NULL
Molecular Weight:
0
MDL Number:
MFCD00081946
MOL File:
Mol file
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
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EC 2.7.1.40 Properties

storage temp. -20°C
form powder
color white
PH ~6
biological source rabbit muscle
Water Solubility Soluble in water ( 1mg/ml).
Specific Activity 350-600units/mg protein
EPA Substance Registry System Kinase (phosphorylating), pyruvate (9001-59-6)
UNSPSC Code 12352204
NACRES NA.54

SAFETY

Risk and Safety Statements

WGK Germany  3
F  10-21
TSCA  TSCA listed
HS Code  35079090
Storage Class 12 - Non Combustible Liquids

EC 2.7.1.40 price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P9136 Pyruvate Kinase from rabbit muscle Type III, lyophilized powder, 350-600?units/mg protein 9001-59-6 1000units $87.7 2026-04-30 Buy
Sigma-Aldrich P9136 Pyruvate Kinase from rabbit muscle Type III, lyophilized powder, 350-600?units/mg protein 9001-59-6 5000units $220 2026-04-30 Buy
Sigma-Aldrich P9136 Pyruvate Kinase from rabbit muscle Type III, lyophilized powder, 350-600?units/mg protein 9001-59-6 25000units $664 2026-04-30 Buy
Sigma-Aldrich P9136 Pyruvate Kinase from rabbit muscle Type III, lyophilized powder, 350-600?units/mg protein 9001-59-6 50000units $1190 2026-04-30 Buy
Sigma-Aldrich P7768 Pyruvate Kinase from rabbit muscle Type VII, buffered aqueous glycerol solution, 350-600?units/mg protein 9001-59-6 1000units $56.4 2026-04-30 Buy
Product number Packaging Price Buy
P9136 1000units $87.7 Buy
P9136 5000units $220 Buy
P9136 25000units $664 Buy
P9136 50000units $1190 Buy
P7768 1000units $56.4 Buy

EC 2.7.1.40 Chemical Properties, Uses, Production

Chemical Properties

White powder

Uses

Pyruvate kinase has been used in the preparation of cell free extract from BL21 CP strain of E. coli culture for highly productive cell-free protein expression. The enzyme has been used to assay the pyruvate kinase activity by incubating with eluted DAPk (Death-associated protein kinase), a serine/threonine kinase that binds and activates pyruvate kinase. It is involved in glycolysis and in gluconeogenesis. It has been used in PGM enzyme assays to determine phosphoglycerate mutase activity. It is also used to study pyruvate kinase (PK) deficiency.

Uses

Pyruvate kinase from rabbit muscle has been used in a structural study to understand the reaction mechanism of the final step in glycolysis. It has also been used in a study to investigate ATP-dependent phosphorylation of α-substituted carboxylic acids.

Uses

Pyruvate kinase from Bacillus stearothermophilus has been used in a study to assess evidence that the genes for phosphofructokinase and pyruvate kinase constitute an operon. It has also been used in a study to investigate the importance of the Lys221 active site for pyruvate kinase activity.

General Description

Pyruvate Kinase (PK) is a glycolysis enzyme and has four isozymes L, R, M1, and M2. The L isozyme is localized in gluconeogenic tissues, particularly in the liver. Whereas the R and M1 are localized in the adult skeletal muscles, heart, brain and erythrocytes, respectively. M2 is localized in the nucleus of the cells.

Biochem/physiol Actions

Molecular Weight: 237 kDaand exists as a tetramer of four equal subunits of molecular weight 57 kDa.Isoelectric Point: 7.6Optimal pH: ～7.5 Optimal Temperature: 25°C ΕA280 = 0.54 for 1 mg(p)/ml, 1 cm path Reported KM values are ATP (0.86 mM), pyruvate (10 mM), ADP (0.3 mM), and PEP (0.07 mM) in Tris buffer at pH 7.4 and 30 °C. Pyruvate kinase is highly specific for phosphoenolpyruvate, but can utilize other dinucleotide triphosphates as substrates in place of ATP including GTP, ITP, dATP, UTP, and CTP.

Purification Methods

These are purified by (NH4)2SO4 fractionation and gel filtration, ion-exchange and affinity chromatography. [Garcia-Olalla & Garrido-Pertierra Biochem J 241 573 1987.]

EC 2.7.1.40 Preparation Products And Raw materials

Raw materials

Ammonium sulfate

Preparation Products

EC 2.7.1.40 Suppliers

Global Suppliers ( 192)
Supplier Tel Email Country ProdList Advantage
Shanghai Baoman Biotechnology Co., Ltd. 021-62130998 baomanbio@163.com China 201 55
Hubei wei shi reagent group ltd., company 13125137732 18686406941 2853863890@qq.com China 2876 58
Nanjing Dulai Biotechnology Co., Ltd. 025-84699383-8003;025-846993838003-8003 18013301590 njduly@126.com China 3293 55
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
ShangHai YuanYe Biotechnology Co., Ltd. 15026964105 shyysw007@163.com China 4998 60
Chengdu Ai Keda Chemical Technology Co., Ltd. 4008-755-333 18080918076 800078821@qq.com China 9706 55
TargetMol Chemicals Inc. 021-021-33632979 15002134094 marketing@targetmol.com China 7993 58
Shanghai BeiZhuo Biotech Co., Ltd. 021-61119791,13386096464 bzswkf@foxmail.com China 3916 50
Supplier Advantage
Shanghai Baoman Biotechnology Co., Ltd. 55
Hubei wei shi reagent group ltd., company 58
Nanjing Dulai Biotechnology Co., Ltd. 55
Beijing Jin Ming Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
ShangHai YuanYe Biotechnology Co., Ltd. 60
Chengdu Ai Keda Chemical Technology Co., Ltd. 55
TargetMol Chemicals Inc. 58
Shanghai BeiZhuo Biotech Co., Ltd. 50

View Latest Price from EC 2.7.1.40 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pyruvate Kinase pictures 2026-09-20 Pyruvate Kinase
9001-59-6
 1g 98.0% 1kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Pyruvate kinase pictures 2026-04-20 Pyruvate kinase
9001-59-6
 10g TargetMol Chemicals Inc.
EC 2.7.1.40 pictures 2025-12-24 EC 2.7.1.40
9001-59-6
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
  • EC 2.7.1.40 pictures
  • EC 2.7.1.40
    9001-59-6
  • $0.10
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd

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ATP:PYRUVATE 2-O-PHOSPHOTRANSFERASE ATP: PYRUVATE O2-PHOSPHOTRANSFERASE EC 2.7.1.40 PK （rabbit muscle) pyruvate phosphoferase PYRUVATE KINASE FROM RABBITMUSCLE CA. 350 U/MG PROTEIN SUSP. Pyruvate Kinase from Bacillus stearothermophilus,ATP:pyruvate 2-O-phosphotransferase, PK Pyruvate Kinase from rabbit muscle,ATP:pyruvate 2-O-phosphotransferase, PK PYRUVATE KINASE, PRESTAINED FROM*CHICKEN MUSCLE PK(R.M.), ATP: pyruvate 2-o-phosphotransferase Pyruvate kinase (from Rabbit muscle), ammonium sulfate suspension Pyruvat kinase from rabbit, lyophil. PHOSPHOENOL PYRUVATE KINASE PYRUVATE KINASE, RABBIT MUSCLE PYRUVATE KINASE TYPE I PYRUVATE KINASE TYPE II PYRUVATE KINASE TYPE III PYRUVATE KINASE TYPE VIII PYRUVATE O2-PHOSPHO TRANSFERASE Pyruvate Kinase, 250 units/Mg Pyruvate Kinase froM MicroorganisM Pyruvate Kinase from rabbit liver Pyruvate Kinase M2 pyruvate kinase from rabbit muscle pyruvate kinase from rabbit muscle cryst susp. ~350 U/mg Pyruvate Kinase preparation from rabbit muscle pyruvate kinase type I crude*from rabbit muscle pyruvate kinase type iii from rabbit*muscle pyruvate kinase type viii from*bacillus stearothe pyruvate kinase type X from chicken*muscle pyruvate kinase type xii from rabbit*liver Kinase (phosphorylating), pyruvate PYRUVATE KINASE TYPE X FROM CHICKEN & PYRUVATE KINASE TYPE VII FROM*RABBIT MUS CLE PYRUVATE KINASE PRESTAINED FROM CHICKEN PYRUVATE KINASE FROM RABBIT MUSCLE, 100- 250 U/MG PYRUVATE KINASE TYPE VIII FROM*BACILLUS STEAROTHERM PYRUVATE KINASE TYPE II FROM RABBIT*MUSC LE PYRUVATE KINASE (EC 2.7.1.40) FROM RABBIT MUSCLE LYOPHILIZED POWDER ESSENTIALLY SALT-FREE PYRUVATE KINASE FROM PORCINE HEART (E.C. 2.7.1.40) PYRUVATE KINASE (EC 2.7.1.40) FROM RABBIT MUSCLE HIGHLY PURIFIED SUSPENSION PYRUVATE KINASE FROM BACILLUS STEAROTHERMOPHILUS PyruvateKinaseExRabbitMuscle Pyruvate kinase from rabbit muscle ca. 350 U/mg protein pyruvic kinase ATP:pyruvate 2-O-phosphotransferase, PK Pyruvate Kinase preparation from canine muscle phosphopyruvate transphos phorylase Pyruvate Kinase, 50 units/mg Pyruvate Kinase M2 from Human, Recombinant Pyruvate kinase M2 Active from Mouse, Recombinant Native Pyruvate Kinase from Thermophillic bacteria Native Bacillus stearothermophilus Pyruvate Kinase EC 2.7.1.40 USP/EP/BP Pyruvate Kinase ex. Rabbit Muscle, 300U/mg PK,pyruvate kinase Pyruvate Kinase from Bacillus stearothermophilus Pyruvate Kinase Activity Microplate Assay Kit