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3-(4-FLUOROBENZOYL)PROPIONIC ACID

3-(4-FLUOROBENZOYL)PROPIONIC ACID structure

CAS No.: 366-77-8

Chemical Name:: 3-(4-FLUOROBENZOYL)PROPIONIC ACID

Synonyms: 4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID;R 11302;AKOS BBS-00006441;LABOTEST-BB LT00233221;HALOPERIDOL METABOLITE III;3-(4-FLUOROBENZOYL)PROPIONIC ACID;4-Fluoro-oxo-benzenebutanoic acid;4-Fluoro-γ-oxobenzenebutyric acid;β-(p-Fluorobenzoyl)propionic acid;3-(4-Fluorobenzoyl)propanoic acid

CBNumber:: CB9412884

Molecular Formula:: C10H9FO3

Molecular Weight:: 196.18

MDL Number:: MFCD00002793

MOL File:: 366-77-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:19:41

Product description	Number	Pack Size	Price
3-(4-Fluorobenzoyl)propionic Acid >97.0%(GC)(T)	F0379	5g	$87
3-(4-Fluorobenzoyl)propionic Acid >97.0%(GC)(T)	F0379	25g	$302
3-(4-Fluorobenzoyl)propionic acid Asreported	276078	500g	$878
3-(4-Fluorobenzoyl)propionic acid Asreported	276078	1kg	$1391
3-(4-Fluorobenzoyl)propionic acid Asreported	276078	2kg	$2380
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3-(4-FLUOROBENZOYL)PROPIONIC ACID Properties

Melting point	100-102 °C (lit.)
Boiling point	374.4±22.0 °C(Predicted)
Density	1.2441 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	powder to crystal
pka	4.50±0.17(Predicted)
color	White to Orange to Green
Water Solubility	Insoluble in water.
BRN	958145
InChI	1S/C10H9FO3/c11-8-3-1-7(2-4-8)9(12)5-6-10(13)14/h1-4H,5-6H2,(H,13,14)
InChIKey	WUYWHIAAQYQKPP-UHFFFAOYSA-N
SMILES	OC(=O)CCC(=O)c1ccc(F)cc1
CAS DataBase Reference	366-77-8(CAS DataBase Reference)
FDA UNII	V2Z6N6JC9Z
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H315-H319-H302

Precautionary statements

P280g-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,C,Xi

Risk Statements

36/37/38-20/21/22-22

Safety Statements

36/37/39-26-22-24/25

WGK Germany

Hazard Note

Corrosive

HazardClass

IRRITANT

HS Code

29183000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	0
2		0

3-(4-FLUOROBENZOYL)PROPIONIC ACID price More Price(61)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	F0379	3-(4-Fluorobenzoyl)propionic Acid >97.0%(GC)(T)	366-77-8	5g	$87	2026-04-30	Buy
TCI Chemical	F0379	3-(4-Fluorobenzoyl)propionic Acid >97.0%(GC)(T)	366-77-8	25g	$302	2026-04-30	Buy
Usbiological	276078	3-(4-Fluorobenzoyl)propionic acid Asreported	366-77-8	500g	$878	2026-06-03	Buy
Usbiological	276078	3-(4-Fluorobenzoyl)propionic acid Asreported	366-77-8	1kg	$1391	2026-06-03	Buy
Usbiological	276078	3-(4-Fluorobenzoyl)propionic acid Asreported	366-77-8	2kg	$2380	2026-06-03	Buy

Product number	Packaging	Price	Buy
F0379	5g	$87	Buy
F0379	25g	$302	Buy
276078	500g	$878	Buy
276078	1kg	$1391	Buy
276078	2kg	$2380	Buy

3-(4-FLUOROBENZOYL)PROPIONIC ACID Chemical Properties,Uses,Production

Chemical Properties

beige granular powder

Uses

7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.

Definition

ChEBI: 4-(4-Fluorophenyl)-4-oxobutanoic acid is an aromatic ketone.

General Description

3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker.

Synthesis

108-30-5

462-06-6

366-77-8

1. aluminum chloride (2.66 g, 20 mmol) was slowly added to a stirred mixture of succinic anhydride (1.00 g, 10 mmol) and fluorobenzene (5.6 mL, 60 mmol) at -5 °C. 2. the reaction temperature was maintained at -5 °C for 1 hour, followed by a slow warming to room temperature, and the reaction continued for 17 hours. 3. the reaction mixture was slowly poured into a stirred 18% HCl aqueous solution (30 mL) at 0 °C and stirring was continued for 30 min while the mixture was allowed to gradually warm up to room temperature. 4. The resulting white powder was collected by filtration and washed with deionized water. 5. The product was 4-(4-(4-hydroxyphenyl)ethyl)ethyl). 5. The product was 4-(4-fluorophenyl)-4-oxobutyric acid in 1.67 g, 85% yield. 6. ; HPLC tR = 1.53 min (>99% purity, mobile phase is an aqueous solution of 80% MeCN).

References

[1] Helvetica Chimica Acta, 1995, vol. 78, # 3, p. 647 - 662
[2] Patent: WO2007/96647, 2007, A2. Location in patent: Page/Page column 148-149
[3] Patent: CN107556287, 2018, A. Location in patent: Paragraph 0036; 0037; 0038; 0039; 0040; 0052; 0053
[4] Patent: CN106187863, 2016, A. Location in patent: Paragraph 0153; 0154; 0155; 0156; 0157; 0104-0108
[5] Tetrahedron Letters, 2016, vol. 57, # 24, p. 2583 - 2586

3-(4-FLUOROBENZOYL)PROPIONIC ACID Preparation Products And Raw materials

Raw materials

Fluorobenzene Succinic anhydride Hydrochloric acid

Preparation Products

IMAZODAN 7-FLUORO-1-TETRALONE (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone 6-(4-FLUOROPHENYL)-4,5-DIHYDRO-3(2H)-PYRIDAZINONE

3-(4-FLUOROBENZOYL)PROPIONIC ACID Suppliers

Global( 187)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
ANHUI WITOP BIOTECH CO., LTD	+8618071025641	eric@witopchemical.com	China	23504	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
Aromsyn Co., Ltd.	+86-0571-85585865 +86-13336024896	CB@aromsyn.com	China	19176	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49859	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Aromsyn Co., Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from 3-(4-FLUOROBENZOYL)PROPIONIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-31	3-(4-FLUOROBENZOYL)PROPIONIC ACID 366-77-8	$1.00	1KG	99%	200kg	Career Henan Chemical Co

3-(4-FLUOROBENZOYL)PROPIONIC ACID
366-77-8
$1.00
99%
Career Henan Chemical Co

3-(4-FLUOROBENZOYL)PROPIONIC ACID Spectrum

3-(4-FLUOROBENZOYL)PROPIONIC ACID(366-77-8)MS 3-(4-FLUOROBENZOYL)PROPIONIC ACID(366-77-8)¹HNMR 3-(4-FLUOROBENZOYL)PROPIONIC ACID(366-77-8)¹³CNMR 3-(4-FLUOROBENZOYL)PROPIONIC ACID(366-77-8)IR1 3-(4-FLUOROBENZOYL)PROPIONIC ACID(366-77-8)IR2 3-(4-FLUOROBENZOYL)PROPIONIC ACID(366-77-8)Raman

366-77-8(3-(4-FLUOROBENZOYL)PROPIONIC ACID)Related Search:

3-(2',4'-DIFLUOROBENZOYL)PROPIONIC ACID METHYL 4-(4-FLUOROPHENYL)-2,4-DIOXOBUTANOATE 3-(4-FLUOROBENZOYL)PROPIONIC ACID Haloperidol ethyl 4-(2,4-difluorophenyl)-2,4-dioxobutanoate

TRANS-2-(4-FLUOROBENZOYL)CYCLOPENTANE-1-CARBOXYLIC ACID 2-METHYL-4-OXO-4-(4'-FLUOROPHENYL)BUTYRIC ACID 4-(3,4-DIFLUOROPHENYL)-4-OXOBUTYRIC ACID TRANS-2-(4-FLUOROBENZOYL)-1-CYCLOHEXANE-CARBOXYLIC ACID, 99 CIS-2-(4-FLUOROBENZOYL)-1-CYCLOHEXANE-CARBOXYLIC ACID, 99

ETHYL 4-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYL-4-OXOBUTYRATE ETHYL 4-(4-FLUOROPHENYL)-4-OXOBUTYRATE CIS-2-(4-FLUOROBENZOYL)CYCLOPENTANE-1-CARBOXYLIC ACID ETHYL 4-(3,4-DIFLUOROPHENYL)-4-OXOBUTYRATE 4-OXO-4-(3,4,5-TRIFLUOROPHENYL)BUTYRIC ACID

ETHYL 4-(2,4-DIFLUOROPHENYL)-4-OXOBUTYRATE ETHYL 4-OXO-4-(3,4,5-TRIFLUOROPHENYL)BUTYRATE 4-(4-fluorophenyl)-4-oxo-2-[(2-thienylmethyl)amino]butanoic acid

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HALOPERIDOL METABOLITE III LABOTEST-BB LT00233221 3-(4'-FLUOROBENZOYL)PROPIONIC ACID 3-(4-FLUOROBENZOYL)PROPIONIC ACID 4-(4-FLUOROPHENYL)-4-OXOBUTYRIC ACID AKOS BBS-00006441 4-FLUORO-R-OXO-BENZENEBUTANOIC ACID Benzenebutanoic acid, 4-fluoro-.gamma.-oxo- 3-(4-Fluorobenzoyl)propionic acid 97% 3-(4-Fluorobenzoyl)propionicacid97% beta-(4-fluorobenzoyl)propionic acid 4-Fluoro-oxo-benzenebutanoic acid R 11302 Haloperidol metabolite III, R 11302 4-Fluoro-γ-oxobenzenebutyric acid 4-Oxo-4-(4-fluorophenyl)butyric acid β-(p-Fluorobenzoyl)propionic acid 3-(4-Fluorobenzoyl)propanoic acid 97% 3-(4-Fluorobenzoyl)propionic acid, 98%+ 3-(4-Fluorobenzoyl)propanoic acid 3-(p-Fluorobenzoyl)-propionic acid 4-(4-fluorophenyl)-4-keto-butyric acid 3-(4-Fluorobenzoyl)propionic Acid 3-(4- 4-(4-Fluorophenyl)-4-oxobutanoic acid 97% 4-(4-fluorophenyl)-4-oxobutanoate 3-(4-Fluorobenzoyl)propionicAcid> Benzenebutanoic acid, 4-fluoro-γ-oxo- 3-(4-Fluorobenzoyl)-propionic acid, 1mg/ml in Methanol 4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID 366-77-8 FC6H4COCH2CH2CO2H CARBOXYLIC ACID Building Blocks C10 Carboxylic Acids Carbonyl Compounds Organic Building Blocks Aromatic Building Blocks Aromatic Propionic Acids Acids & Esters Fluorine Compounds