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5-Chloro-2-methoxybenzoic acid

5-Chloro-2-methoxybenzoic acid structure

CAS No.: 3438-16-2

Chemical Name:: 5-Chloro-2-methoxybenzoic acid

Synonyms: Glyburide IMP;Compound Fr12564;RARECHEM AL BO 0576;5-CHLORO-O-ANISIC ACID;5-CHLORO-2-ANISIC ACID;Glyburide IMP Impurity;2-Carboxy-4-chloroanisole;5-Chloro-2-methoxybenzoic;5-Chloro-o-anisic acid,99%;5-chloro-2-methoxybenzoate

CBNumber:: CB9424205

Molecular Formula:: C8H7ClO3

Molecular Weight:: 186.59

MDL Number:: MFCD00017546

MOL File:: 3438-16-2.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:46

Product description	Number	Pack Size	Price
5-Chloro-2-methoxybenzoic acid 99%	292494	25g	$38.64
5-Chloro-2-methoxybenzoic Acid >98.0%(T)	C1539	25g	$93
5-Chloro-2-methoxybenzoic Acid	C367910	25g	$50
5-Chloro-2-methoxybenzoic acid 97%	2621-5-Y2	100g	$141
5-Chloro-2-methoxybenzoic acid	FC36354	500g	$125
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5-Chloro-2-methoxybenzoic acid Properties

Melting point	98-100 °C (lit.)
Boiling point	150-152C
Density	1,259g/cm
refractive index	1,544-1546
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Methanol
pka	3.72±0.10(Predicted)
form	Crystalline Powder
color	White to off-white
InChI	InChI=1S/C8H7ClO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4H,1H3,(H,10,11)
InChIKey	HULDRQRKKXRXBI-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC(Cl)=CC=C1OC
LogP	2.368 (est)
CAS DataBase Reference	3438-16-2(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39-36

WGK Germany

Hazard Note

Irritant

HS Code

29189900

NFPA 704

	1
2		0

5-Chloro-2-methoxybenzoic acid price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	292494	5-Chloro-2-methoxybenzoic acid 99%	3438-16-2	25g	$38.64	2025-07-31	Buy
TCI Chemical	C1539	5-Chloro-2-methoxybenzoic Acid >98.0%(T)	3438-16-2	25g	$93	2025-07-31	Buy
TRC	C367910	5-Chloro-2-methoxybenzoic Acid	3438-16-2	25g	$50	2021-12-16	Buy
SynQuest Laboratories	2621-5-Y2	5-Chloro-2-methoxybenzoic acid 97%	3438-16-2	100g	$141	2021-12-16	Buy
Biosynth Carbosynth	FC36354	5-Chloro-2-methoxybenzoic acid	3438-16-2	500g	$125	2021-12-16	Buy

Product number	Packaging	Price	Buy
292494	25g	$38.64	Buy
C1539	25g	$93	Buy
C367910	25g	$50	Buy
2621-5-Y2	100g	$141	Buy
FC36354	500g	$125	Buy

5-Chloro-2-methoxybenzoic acid Chemical Properties,Uses,Production

Chemical Properties

White to off-white crystalline powder

Uses

5-Chloro-2-methoxybenzoic acid has been used in the synthesis of 5-chloro-2-methoxybenzoates of La(III), Ga(III) and Lu(III).

General Description

Complexes of 4-chloro-2-methoxybenzoic acid anion with Mn²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺have been investigated.

Synthesis

33924-48-0

3438-16-2

General procedure for the synthesis of 5-chloro-2-methoxybenzoic acid from methyl 5-chloro-2-methoxybenzoate: to a 1 M aqueous sodium hydroxide solution (60 mL, 0.06 mol) was added a solution of methyl 5-chloro-2-methoxybenzoate (2.0 g, 0.01 mol) [Alfa Aesar] in ethanol (60 mL). The reaction mixture was stirred at room temperature for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until completion of the reaction. Subsequently, the reaction mixture was concentrated under reduced pressure to remove ethanol and the residue was separated by extraction with ethyl acetate. The aqueous phase was cooled in an ice bath and the pH was adjusted with concentrated aqueous hydrochloric acid to 2. After continued stirring in an ice bath for 1 h, the precipitated solid was collected by filtration, washed with water and dried in air to afford 1.4 g (74.9% yield) of the target product, 5-chloro-2-methoxybenzoic acid, as a white solid. Mass spectrum (MS): m/z 185.1 (MH+). 1H NMR (500 MHz, DMSO-d6): δ 3.818 (s, 3H), 7.162 (d, 1H), 7.551 (dd, 1H), 7.607 (d, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 21, p. 6819 - 6829
[2] Patent: WO2014/165816, 2014, A1. Location in patent: Page/Page column 98-99
[3] Journal of the American Chemical Society, 1988, vol. 110, p. 7178
[4] Patent: US4895860, 1990, A

5-Chloro-2-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

5-Chloro-2-hydroxybenzoic acid Dimethyl sulfate METHYL 5-CHLORO-2-METHOXYBENZOATE carbon monoxide 2,4-DICHLOROANISOLE

Sodium hydroxide Ethanol Water

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Preparation Products

4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE 5-CHLORO-2-METHOXYBENZOYL CHLORIDE 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide PF-06282999 IMD-0354

5-CHLORO-2-METHOXY-N-(2-PHENYLETHYL)BENZAMIDE 5-Chloro-2-methoxy-benzoic acid hydrazide

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5-Chloro-2-methoxybenzoic acid Suppliers

Global( 251)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3999	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29798	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58

View Lastest Price from 5-Chloro-2-methoxybenzoic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-07-25	5-Chloro-2-methoxybenzoic acid 3438-16-2	US $1.00 / Kg	1Kg	98%	20T	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	5-Chloro-2-methoxybenzoic acid 3438-16-2	US $1.00 / kg	1kg	95%-99%	100kg	Career Henan Chemical Co

5-Chloro-2-methoxybenzoic acid
3438-16-2
US $1.00 / Kg
98%
Shaanxi Dideu Medichem Co. Ltd

5-Chloro-2-methoxybenzoic acid
3438-16-2
US $1.00 / kg
95%-99%
Career Henan Chemical Co

5-Chloro-2-methoxybenzoic acid Spectrum

5-Chloro-2-methoxybenzoic acid(3438-16-2)MS 5-Chloro-2-methoxybenzoic acid(3438-16-2)¹HNMR 5-Chloro-2-methoxybenzoic acid(3438-16-2)¹³CNMR 5-Chloro-2-methoxybenzoic acid(3438-16-2)IR1 5-Chloro-2-methoxybenzoic acid(3438-16-2)Raman

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3-CHLORO-2,6-DIMETHOXY-5-NITROBENZOIC ACID N-ACETYL-4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID, METHYL ESTER,4-ACETAMIDO-5-CHLORO-2-METHOXYBENZOIC ACID METHYL ESTER 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID

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2-Carboxy-4-chloroanisole 5-Chloro-N-(2-phenylethyl)-2-MethoxybenzaMide Glyburide IMP RARECHEM AL BO 0576 5-Chloro-o-anisic acid,99% 2-METHOXY-5-CHLOROBENZOIC ACID 5-CHLORO-2-METHOXYBENZOIC ACID 5-CHLORO-2-ANISIC ACID 5-CHLORO-O-ANISIC ACID 5-Chloro-2-methoxybenzoicacid,98% 5-Chloro-2-methoxybenzoicacid,99% 5-chloro-2-methoxybenzoic acid (intermediate of glibenclamide) 5-Chloro-2-methoxybenzoic acid 97% 5-CHLORO-2-METHOXYBENZOIC ACID / 5-CHLORO-O-ANISIC ACID 5-chloro-2-methoxybenzoate 5-Chloro-2-methoxybenzoicAcid> Benzoic acid, 5-chloro-2-methoxy- 5-Chloro-2-methoxybenzoic acid (Glibenclamide Impurity) 5-Chloro-2-methoxybenzoic Compound Fr12564 Glibenclamide impurity 9(5-Chloro-2-methoxybenzoic acid) Glyburide IMP Impurity 3438-16-2 5438-16-2 Organic Building Blocks Heterocyclic Building Blocks Pyrimidines Building Blocks Carbonyl Compounds Carboxylic Acids C8 API Intermediate FINE Chemical & INTERMEDIATES Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Organic acids (intermediate of glibenclamide) Miscellaneous Acids & Esters Anisoles, Alkyloxy Compounds & Phenylacetates Chlorine Compounds