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2-Chloro-5-pyridineacetonitrile

2-Chloro-5-pyridineacetonitrile structure

CAS No.: 39891-09-3

Chemical Name:: 2-Chloro-5-pyridineacetonitrile

Synonyms: 2-Chloro-5-pyridinea;2-chloro-5-acetonitrile;oro-5-pyridineacetonitriL;2-CHLORO-5-PYRIDINEACETONITRILE;2-CHLOROPYRIDINE-5-ACETONITRILE;6-Chloro-3-pyridineacetonitrile;6-Chloro-3-(cyanomethyl)pyridine;2-CHLORO-5-(CYANOMETHYL)PYRIDINE;3-Pyridineacetonitrile, 6-chloro-;2-(6-chloropyridin-3-yl)acetonitrile

CBNumber:: CB9450903

Molecular Formula:: C7H5ClN2

Molecular Weight:: 152.58

MDL Number:: MFCD04112495

MOL File:: 39891-09-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:27:13

Product description	Number	Pack Size	Price
2-Chloropyridine-5-acetonitrile 95%	734810	5g	$54.8
2-Chloro-5-cyanomethylpyridine	C380763	1g	$55
2-Chloro-5-(cyanomethyl)pyridine	FC10678	10g	$70
2-Chloro-5-(cyanomethyl)pyridine	FC10678	25g	$137.5
2-(6-Chloro-3-pyridinyl)acetonitrile 98%	023735	25g	$143
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2-Chloro-5-pyridineacetonitrile Properties

Melting point	49-54°C
Boiling point	182 °C(Press: 1 Torr)
Density	1.262±0.06 g/cm3(Predicted)
Flash point	>110℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-1.02±0.10(Predicted)
form	solid
Appearance	Brown to reddish brown Solid
InChI	InChI=1S/C7H5ClN2/c8-7-2-1-6(3-4-9)5-10-7/h1-2,5H,3H2
InChIKey	BLGUCBUETMYJTB-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=CC=C1CC#N
CAS DataBase Reference	39891-09-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS06
Signal word	Danger
Hazard statements	H301-H315-H318-H335
Precautionary statements	P280-P301+P310+P330-P302+P352-P305+P351+P338+P310
target organs	Respiratory system
Hazard Codes	Xi,T,Xn
Risk Statements	22-37/38-41
Safety Statements	26-39
RIDADR	UN 3439 6.1 / PGIII
WGK Germany	3
HazardClass	IRRITANT, TOXIC
HS Code	2933399990
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3
Limited Quantities	5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities	Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

2-Chloro-5-pyridineacetonitrile price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	734810	2-Chloropyridine-5-acetonitrile 95%	39891-09-3	5g	$54.8	2026-04-30	Buy
TRC	C380763	2-Chloro-5-cyanomethylpyridine	39891-09-3	1g	$55	2021-12-16	Buy
Biosynth Carbosynth	FC10678	2-Chloro-5-(cyanomethyl)pyridine	39891-09-3	10g	$70	2021-12-16	Buy
Biosynth Carbosynth	FC10678	2-Chloro-5-(cyanomethyl)pyridine	39891-09-3	25g	$137.5	2021-12-16	Buy
Matrix Scientific	023735	2-(6-Chloro-3-pyridinyl)acetonitrile 98%	39891-09-3	25g	$143	2021-12-16	Buy

Product number	Packaging	Price	Buy
734810	5g	$54.8	Buy
C380763	1g	$55	Buy
FC10678	10g	$70	Buy
FC10678	25g	$137.5	Buy
023735	25g	$143	Buy

2-Chloro-5-pyridineacetonitrile Chemical Properties,Uses,Production

Uses

2-Chloro-5-cyanomethylpyridine

Synthesis

773837-37-9

70258-18-3

39891-09-3

General procedure for the synthesis of 2-chloro-5-pyridylacetonitrile from 2-chloro-5-chloromethylpyridine and sodium cyanide: Step 1. Synthesis of (6-chloropyridin-3-yl)acetonitrile. To a stirred solution of 2-chloro-5-chloromethylpyridine (25 g, 0.154 mol) in ethanol (40 mL) was slowly added an aqueous solution of sodium cyanide (8.17 g, 0.167 mol) (18 mL) at 0 °C. The reaction mixture was heated to reflux for 2 hours, followed by continued stirring at room temperature for 18 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation and the residue was dissolved in water and extracted with dichloromethane (500 mL). The organic phase was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography with the eluent being a 70/30 dichloromethane/hexane solvent mixture to give 20 g (85% yield) of brown oily product. The product was solidified by standing and ESI-MS m/z 153 (MH+).

References

[1] Patent: WO2010/130708, 2010, A1. Location in patent: Page/Page column 105
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 7, p. 2168 - 2173
[3] Patent: WO2013/13817, 2013, A1. Location in patent: Page/Page column 111
[4] Patent: WO2013/13815, 2013, A1. Location in patent: Page/Page column 221
[5] Patent: US2013/29961, 2013, A1. Location in patent: Paragraph 0705

2-Chloro-5-pyridineacetonitrile Preparation Products And Raw materials

Raw materials

sodium:cyanide 2-Chloro-5-(chloromethyl)pyridine Sodium cyanide POTASSIUM CYANIDE

Preparation Products

BIPY531, 2,2'-([2,2'-Bipyridine]-5,5'-diyl)diacetonitrile Cyclobutanecarbonitrile, 1-[6-[5-(methylamino)-2-pyrazinyl]-3-pyridinyl]- Cyclobutanecarbonitrile, 1-[6-(2-amino-5-pyrimidinyl)-3-pyridinyl]- Pyridine, 2-chloro-5-[1-[5-(3-pyridinyl)-1,2,4-oxadiazol-3-yl]cyclobutyl]- Cyclobutanecarbonitrile, 1-[6-(5-amino-2-pyrazinyl)-3-pyridinyl]-

1-(6-Chloropyridin-3-yl)cyclobutanecarbonitrile (6-tert-Butoxycarbonylamino-pyridin-3-yl)-acetic acid

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2-Chloro-5-pyridineacetonitrile Suppliers

Global( 186)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Accela ChemBio Inc.	58
Changzhou Carman Chemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from 2-Chloro-5-pyridineacetonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-01	2-Chloro-5-pyridineacetonitrile 39891-09-3	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-11-18	2-Chloro-5-pyridineacetonitrile 39891-09-3	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-09-25	2-Chloro-5-pyridineacetonitrile 39891-09-3	US $5.00-0.10 / KG	1KG	98%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

2-Chloro-5-pyridineacetonitrile
39891-09-3
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-Chloro-5-pyridineacetonitrile
39891-09-3
US $1.10 / g
99.00%
Dideu Industries Group Limited

2-Chloro-5-pyridineacetonitrile
39891-09-3
US $5.00-0.10 / KG
98%
Henan Fengda Chemical Co., Ltd

2-Chloro-5-pyridineacetonitrile Spectrum

2-Chloro-5-pyridineacetonitrile(39891-09-3)¹HNMR

39891-09-3(2-Chloro-5-pyridineacetonitrile)Related Search:

Pentachloropyridine 2-Chloro-5-fluoropyridine Epichlorohydrin 2-Chloro-3-cyanopyridine Pyridine

2-Pyridylacetonitrile 2,6-Lutidine 2-Chloro-5-chloromethylpyridine Chloroacetonitrile Clopidol

Glycolonitrile Chloroacetic acid Benzeneacetonitrile 2-Chloropyridine Difluorochloromethane

acetonitrile 3-PYRIDYLACETONITRILE 4,6-Dichloropyridine-3-acetonitrile

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2-CHLORO-5-PYRIDINEACETONITRILE 2-(6-CHLORO-3-PYRIDINYL)ACETONITRILE 2-CHLORO-5-(CYANOMETHYL)PYRIDINE 2-CHLOROPYRIDINE-5-ACETONITRILE (6-CHLORO-PYRIDIN-3-YL)-ACETONITRILE 2-(6-chloropyridin-3-yl)acetonitrile 2-Chloro-5-pyridinea 6-Chloro-3-(cyanomethyl)pyridine 2-chloro-5-acetonitrile 6-Chloro-3-pyridineacetonitrile oro-5-pyridineacetonitriL 3-Pyridineacetonitrile, 6-chloro- 2-Chloro-5-pyridineacetonitrile ISO 9001：2015 REACH 39891-09-3 Pyridines Pyridine