PF-06700841-TsOH
- CAS No.
- 2140301-96-6
- Chemical Name:
- PF-06700841-TsOH
- Synonyms
- CS-2860;PF 06700841-15;PF-06700841-TsOH;PF-06700841 free base;Brepocitinib tosylate;PF-06700841 P-TOSYLATE;Brepocitinib (P-Tosylate);Brepocitinib P-Tosylate, 10 mM in DMSO;Janus kinase,JAK,Brepocitinib P-Tosylate,inhibit,Brepocitinib PTosylate,Inhibitor,Brepocitinib P Tosylate;((S)-2,2-Difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone 4-methylbenzenesulfonate
- CBNumber:
- CB94675331
- Molecular Formula:
- C25H29F2N7O4S
- Molecular Weight:
- 561.61
- MDL Number:
- MFCD30480911
- MOL File:
- 2140301-96-6.mol
| Product description | Number | Pack Size | Price |
| PF-06700841 (tosylate) | 26125 | 1mg | $32 |
| PF-06700841 (tosylate) | 26125 | 10mg | $169 |
| PF-06700841 (tosylate) ≥98% | 26125 | 25mg | $343 |
| PF-06700841 (tosylate) | 26125 | 5mg | $100 |
| PF-06700841(P-Tosylate) 99.66% | CS-0066286 | 10mg | $140 |
| More product size | |||
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:20): 50μg/ml; Ethanol: slightly soluble |
| form | A crystalline solid |
| color | White to off-white |
| InChIKey | FAKGOYNHHHOTEN-QYGWXNHUNA-N |
| SMILES | S(C1C=CC(C)=CC=1)(O)(=O)=O.C([C@@H]1CC1(F)F)(N1C2CCC1CN(C1C=CN=C(NC3=CN(C)N=C3)N=1)C2)=O |&1:12,r| |
| FDA UNII | C960DPP15O |
PF-06700841-TsOH price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26125 | PF-06700841 (tosylate) | 2140301-96-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 26125 | PF-06700841 (tosylate) | 2140301-96-6 | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 26125 | PF-06700841 (tosylate) ≥98% | 2140301-96-6 | 25mg | $343 | 2024-03-01 | Buy |
| Cayman Chemical | 26125 | PF-06700841 (tosylate) | 2140301-96-6 | 5mg | $100 | 2024-03-01 | Buy |
| ChemScene | CS-0066286 | PF-06700841(P-Tosylate) 99.66% | 2140301-96-6 | 10mg | $140 | 2021-12-16 | Buy |
PF-06700841-TsOH Chemical Properties,Uses,Production
Uses
Brepocitinib (PF-06700841) P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib P-Tosylate also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively[1].
in vivo
Brepocitinib (Compound 23; 3-30 mg/kg; oral administration; for 7 consecutive days; female Lewis rats) treatment significantly reduces paw volume increase in a dose-dependent manner. The plasma concentrations in animals dosed with Brepocitinib at peak (30 min) and trough (24 h) time intervals post final dose respectively are as follows: 3 mg/kg, 3.54 μM, 0.0221 μM; 10 mg/kg, 10.95 μM, 0.06 μM; and 30 mg/kg, 23.89 μM, 0.06 μM[1].
| Animal Model: | Female Lewis rats with induced arthritis[1] |
| Dosage: | 3 mg/kg, 10 mg/kg, or 30 mg/kg |
| Administration: | Oral administration; for 7 consecutive days |
| Result: | Increased in paw volume was significantly lower and dose-dependent. |
IC 50
JAK1: 17 nM (IC50); JAK2: 77 nM (IC50); JAK3: 6.9 μM (IC50)
References
[1] Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700 DOI:10.1021/acs.jmedchem.8b00917
PF-06700841-TsOH Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Fujian boshi pharmaceutical technology co. LTD | 0595-22008920; 18120708884 | 393612455@qq.com | China | 255 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 18971495150; | sales@sun-shinechem.com | China | 1112 | 64 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4800 | 55 |
View Lastest Price from PF-06700841-TsOH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | Brepocitinib P-Tosylate
2140301-96-6
|
US $64.00-228.00 / mg | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-02-02 | Brepocitinib P-Tosylate
2140301-96-6
|
US $64.00-228.00 / mg | 99.89% | 10g | TargetMol Chemicals Inc. |
-
- Brepocitinib P-Tosylate
2140301-96-6
- US $64.00-228.00 / mg
- 99.89%
- TargetMol Chemicals Inc.
-
- Brepocitinib P-Tosylate
2140301-96-6
- US $64.00-228.00 / mg
- 99.89%
- TargetMol Chemicals Inc.
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