Methyl diethylphosphonoacetate
- CAS No.
- 1067-74-9
- Chemical Name:
- Methyl diethylphosphonoacetate
- Synonyms
- POME;APAZ-027;NSC 147757;LABOTEST-BB LT00452673;Mirogabalin Impurity 59;DIETHYLMETHYLPHOSPHONOACETATE;Methyl 2-(diethoxyphosphoryl);METHYL DIETHYLPHOSPHONOACETATE;MethylDiethylphosphonoacetate>Diethyl methyl phosphonylacetate
- CBNumber:
- CB9468917
- Molecular Formula:
- C7H15O5P
- Molecular Weight:
- 210.16
- MDL Number:
- MFCD00009081
- MOL File:
- 1067-74-9.mol
| Boiling point | 127-131 °C9 mm Hg(lit.) |
|---|---|
| Density | 1.145 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Miscible with tetrahydrofuran. |
| form | Liquid |
| color | Clear colorless to faint yellow |
| BRN | 1782397 |
| InChI | InChI=1S/C7H15O5P/c1-4-11-13(9,12-5-2)6-7(8)10-3/h4-6H2,1-3H3 |
| InChIKey | CTSAXXHOGZNKJR-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)CP(OCC)(OCC)=O |
| CAS DataBase Reference | 1067-74-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, phosphono-, p,p-diethyl c-methyl ester(1067-74-9) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
Methyl diethylphosphonoacetate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 158763 | Methyl diethylphosphonoacetate 97% | 1067-74-9 | 10g | $59.99 | 2025-07-31 | Buy |
| Sigma-Aldrich | 158763 | Methyl diethylphosphonoacetate 97% | 1067-74-9 | 50g | $175 | 2025-07-31 | Buy |
| TCI Chemical | D2873 | Methyl Diethylphosphonoacetate >96.0%(GC) | 1067-74-9 | 5g | $20 | 2025-07-31 | Buy |
| TCI Chemical | D2873 | Methyl Diethylphosphonoacetate >96.0%(GC) | 1067-74-9 | 25g | $47 | 2025-07-31 | Buy |
| Usbiological | 283239 | Methyl diethylphosphonoacetate | 1067-74-9 | 3.51g | $297 | 2021-12-16 | Buy |
Methyl diethylphosphonoacetate Chemical Properties,Uses,Production
Chemical Properties
Clear colorless to slightly yellow liquid
Uses
Methyl diethylphosphonoacetate is used as a reagent in the preparation of allylic fluorides compounds and in regioselective Diels-Alder reactions. It also serves as a reactant in the preparation of substituted thiophenes and furans, which finds application in type 2 diabetes treatment. Further, it acts as a precursor in the synthesis of pyridone alkaloids and immunosuppressive cyclopentanediol derivatives. In addition to this, it is utilized in the modification of botulinum neurotoxin serotype A protease inhibitors.
reaction suitability
reaction type: C-C Bond Formation
Synthesis
64-17-5
![Acetic acid, 2-[bis[(trimethylsilyl)oxy]phosphinyl]-, methyl ester](/CAS/20210111/GIF/67605-34-9.gif)
67605-34-9
1067-74-9
TMSBr (90 μL, 0.691 mmol) was added to a solution of anhydrous CH2Cl2 (0.55 mL) of trimethyl phosphonoacetate (2; 50.3 mg, 0.276 mmol) at room temperature. After the reaction mixture was stirred under argon protection at room temperature for 5 h, the solvent was removed by vacuum evaporation to afford methyl 2-[bis[(trimethylmethylsilyl)oxy]phosphono}acetate (4), which was used for the next reaction without further purification. Subsequently, Ph3P (181 mg, 0.691 mmol) and I2 (175 mg, 0.691 mmol) were added to an anhydrous CHCl3 (1.8 mL) solution of 4 under argon protection. The reaction mixture was stirred at room temperature for 15 minutes and then imidazole (188 mg, 2.76 mmol) was added. Stirring was continued at room temperature for 15 minutes, then the reaction mixture was heated to 50°C and held for 30 minutes. Next, 2,2,2-trifluoroethanol (79 μl, 1.10 mmol) was added and the reaction mixture was stirred at 60°C for 5 hours. Upon completion of the reaction, the reaction mixture was filtered and the filtrate was evaporated under vacuum to give the crude product 1. The crude product was purified by column chromatography [silica gel PSQ 60B: n-hexane-EtOAc (2:1)] to give the final product methyl diethylphosphonoacetate (1; 82.3 mg, 94%) as a colorless oil.
References
[1] Synlett, 2018, vol. 29, # 11, p. 1461 - 1464
Methyl diethylphosphonoacetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +8615888611133 | dave@jxswchem.com | China | 22 | 58 |
| Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +8615888611133 | dave@jxswchem.com | China | 22 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12587 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20202 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12888 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
View Lastest Price from Methyl diethylphosphonoacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-08 | Methyl diethylphosphonoacetate
1067-74-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-06-27 | Methyl diethylphosphonoacetate
1067-74-9
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-20 | Methyl diethylphosphonoacetate
1067-74-9
|
US $20.00-1.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Methyl diethylphosphonoacetate
1067-74-9
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- Methyl diethylphosphonoacetate
1067-74-9
- US $0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Methyl diethylphosphonoacetate
1067-74-9
- US $20.00-1.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
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