Ryngo 1-23
- CAS No.
- 171674-76-3
- Chemical Name:
- Ryngo 1-23
- Synonyms
- Ryngo 1-23;Bis T 23,BisT23;Bis-T-23 (Ryngo 1-23);Ryngo 1-23, Dynamin activator;1,3-Bis(2-cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamino)propane;2-Propenamide,N,N'-1,3-propanediylbis[2-cyano-3-(3,4,5-?trihydroxyphenyl)-,(2E,2'E)-
- CBNumber:
- CB94718656
- Molecular Formula:
- C23H20N4O8
- Molecular Weight:
- 480.43
- MDL Number:
- MFCD32644553
- MOL File:
- 171674-76-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Ryngo 1-23 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 44119 | Bis-T-23 ≥90% | 171674-76-3 | 1mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 44119 | Bis-T-23 ≥90% | 171674-76-3 | 5mg | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 44119 | Bis-T-23 ≥90% | 171674-76-3 | 10mg | $504 | 2026-04-30 | Buy |
| Biosynth | WGA67476 | 1,3-Bis(2-cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamino)propane | 171674-76-3 | 25mg | $1237.25 | 2026-06-05 | Buy |
| Biosynth | WGA67476 | 1,3-Bis(2-cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamino)propane | 171674-76-3 | 50mg | $1721 | 2026-06-05 | Buy |
Ryngo 1-23 Chemical Properties,Uses,Production
Description
AG 1717, also known as Bis-T-23, is a promoter of actin-dependent dynamin oligomerization. It acts by increasing actin polymerization in injured podocytes.
Uses
Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD)[1][2].
in vivo
Bis-T-23 (AG1717) (1 ng) targets actin-dependent dynamin oligomerization in podocytes to promote proper GFB function[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorate proteinuria by altering actin dynamics[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorates or prevented proteinuria and diminished mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents[1].
| Animal Model: | Sprague-Dawley rats (8 weeks old, males); Mice[1] |
| Dosage: | 20, 40 mg/kg; 40 mg/kg |
| Administration: | Intraperitoneal injection; signle, once for 6 consecutive days |
| Result: | Specifically reduced proteinuria on days 18 and 24. Caused a transient reduction of proteinuria (single dose) in PKCε KO mice. Completely prevented the onset of high-level proteinuria in the CD2AP KO mice. Significantly extended the lifespans of CD2AP KO mice. Led to improved glomerular histology with less mesangial matrix accumulation. |
| Animal Model: | Zebrafish[1] |
| Dosage: | 1 ng |
| Administration: | Injection |
| Result: | Promoted oligomerization of zebrafish Dyn2. Increased the number of focal adhesions (FAs) and stress fibers in cultured podocytes. |
References
[1] Schiffer M, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015;21(6):601-609. DOI:10.1038/nm.3843
[2] Mazumder, A.,et al. Effects of Tyrphostins, Protein Kinase Inhibitors, on Human Immunodeficiency Virus Type 1 Integrase. Biochemistry, 1995, 34(46), 15111–15122.
Ryngo 1-23 Preparation Products And Raw materials
Raw materials
Preparation Products
Ryngo 1-23 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9795 | 55 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
