Axitinib-13C-d3
- CAS No.
- 1261432-00-1
- Chemical Name:
- Axitinib-13C-d3
- Synonyms
- Axitinib-13C-d3;[13C,2H3]-Axitinib;Axitinib-[13C,D3] (Standard);(E)-N-(methyl-13C-d3)-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
- CBNumber:
- CB94814349
- Molecular Formula:
- C22H15D3N4OS
- Molecular Weight:
- 390.48
- MDL Number:
- MFCD32858131
- MOL File:
- 1261432-00-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Axitinib-13C-d3 ≥99%deuteratedforms(d1-d3) | 26676 | 500μg | $659 |
| Axitinib-13C-d3 ≥99%deuteratedforms(d1-d3) | 26676 | 1mg | $1054 |
| Axitinib-13C,d3 97.80% | CS-0169728 | 1mg | $596 |
| Axitinib-13C,d3 97.80% | CS-0169728 | 5mg | $1712 |
| Axitinib-13C,d3 97.80% | CS-0169728 | 10mg | $2708 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501 | |||||||||
| NFPA 704 |
|
Axitinib-13C-d3 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26676 | Axitinib-13C-d3 ≥99%deuteratedforms(d1-d3) | 1261432-00-1 | 500μg | $659 | 2026-04-30 | Buy |
| Cayman Chemical | 26676 | Axitinib-13C-d3 ≥99%deuteratedforms(d1-d3) | 1261432-00-1 | 1mg | $1054 | 2026-04-30 | Buy |
| ChemScene | CS-0169728 | Axitinib-13C,d3 97.80% | 1261432-00-1 | 1mg | $596 | 2026-06-04 | Buy |
| ChemScene | CS-0169728 | Axitinib-13C,d3 97.80% | 1261432-00-1 | 5mg | $1712 | 2026-06-04 | Buy |
| ChemScene | CS-0169728 | Axitinib-13C,d3 97.80% | 1261432-00-1 | 10mg | $2708 | 2026-06-04 | Buy |
Axitinib-13C-d3 Chemical Properties,Uses,Production
Description
Axitinib-13C-d3 is intended for use as an internal standard for the quantification of axitinib by GC- or LC-MS. Axitinib is a VEGFR inhibitor (IC50s = 1.2, 0.25, and 0.29 nM for VEGFR1, -2, and -3, respectively). It also inhibits c-Kit and PDGFRβ (IC50s = 1.7 and 1.6 nM, respectively). It inhibits VEGF-induced migration of and tube formation by human umbilical vein endothelial cells (HUVECs). Axitinib (1-100 mg/kg) reduces microvessel density, a marker of angiogenesis, and tumor growth in MV522 colon carcinoma, A375 melanoma, SN12C-GFP renal carcinoma, and U87 glioma mouse xenograft models in a dose-dependent manner. Formulations containing axitinib have been used in the treatment of renal cell carcinoma.
Uses
Axitinib-13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50 values of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively[1][2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Fenton BM, et al. The addition of AG-013736 to rractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Cancer Res. 2007 Oct 15;67(20):9921-8.;Hu-Lowe DD, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 2008 Nov 15;14(22):7272-83;Allen E, et al. Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell Rep. 2016 May 10;15(6):1144-60. DOI:10.1016/j.celrep.2016.04.029
Axitinib-13C-d3 Preparation Products And Raw materials
Raw materials
Preparation Products
Axitinib-13C-d3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-025-85560043 17301488900 | info@synzest.com | China | 9274 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24318 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4719 | 58 |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 13120558703 | sales@scrbio.com | China | 9863 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Hubei Moco Chemical Co., Ltd. | 18627753421; 18627756402 | 3001051413@qq.com | China | 20013 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 18019219489 18901678489 | tech@zzbioco.com | China | 12062 | 58 |
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