BJE6-106 (B106)
- CAS No.
- 1564249-38-2
- Chemical Name:
- BJE6-106 (B106)
- Synonyms
- B106;BJE6-106 (B106);BJE6106,BJE-6-106,BJE6 106;2H-1-Benzopyran-8-carboxaldehyde, 6-[2-(9H-carbazol-9-yl)ethyl]-2,2-dimethyl-
- CBNumber:
- CB94844560
- Molecular Formula:
- C26H23NO2
- Molecular Weight:
- 381.47
- MDL Number:
- MFCD32197190
- MOL File:
- 1564249-38-2.mol
BJE6-106 (B106) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Axon Medchem | Axon2981 | B106-BJE6-106 98% | 1564249-38-2 | 5mg | $148.5 | 2021-12-16 | Buy |
| ChemScene | CS-0068104 | BJE6-106 98.17% | 1564249-38-2 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0068104 | BJE6-106 98.17% | 1564249-38-2 | 10mg | $590 | 2021-12-16 | Buy |
| ChemScene | CS-0068104 | BJE6-106 98.17% | 1564249-38-2 | 50mg | $1800 | 2021-12-16 | Buy |
| ChemScene | CS-0068104 | BJE6-106 98.17% | 1564249-38-2 | 100mg | $2800 | 2021-12-16 | Buy |
BJE6-106 (B106) Chemical Properties,Uses,Production
Uses
BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.
Biological Activity
BJE6-106 (B106) is a potent and selective PKCδ inhibitor with IC50 value of 0.05 μM, BJE6-106 (B106) targets PKCδ 1000-fold more selective than the PKC isoenzyme PKCα (IC50=50 μM) . BJE6-106 (B106) induces apoptosis in caspase-dependent cells. BJE6-106 (B106) has tumor-specific effects.
in vitro
BJE6-106 (B106) (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations. BJE6-106 (B106) (0.2 μM, 0.5 μM; 6- 24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells. BJE6-106 (B106) (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells.
Cell Viability Assay
| Cell Line: | Melanoma cell lines with NRAS mutations: SBcl2, FM6, SKMEL2, WM1366, WM1361A, and WM852 cells |
| Concentration: | 0.2 μM, 0.5 μM |
| Incubation Time: | 24 hours, 48 hours, or 72 hours |
| Result: | Inhibited cell survival in melanoma cell lines. |
Apoptosis Analysis
| Cell Line: | < td class="col2"> SBcl2 cells|
| Concentration: | 0.2 μM, 0.5 μM |
| Incubation Time: | 6 hours, 12 hours, or 24 hours |
| Result: | Induced caspase 3/7 activation. |
Western Blot Analysis
| Cell Line : | SBcl2 cells |
| Concentration: | 0.2 μM , 0.5 μM |
| Incubation Time: | 2 hours, 5 hours, 10 hours | < /tr>
| Increased phosphorylation of MKK4, JNK and H2AX. |
target
| PKCδ 0.05 μM (IC 50 ) | PKCα 50 μM (IC 50 ) |
IC 50
PKCδ: 0.05 μM (IC50); PKCα: 50 μM (IC50)
References
[1] Takashima A,et al. Protein kinase Cδ is a therapeutic target in malignant melanoma with NRAS mutation. ACS Chem Biol. 2014 Apr 18;9(4):1003-14. DOI:10.1021/cb400837t
BJE6-106 (B106) Preparation Products And Raw materials
Raw materials
Preparation Products
BJE6-106 (B106) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7781 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
