KIRA-7
- CAS No.
- 1937235-76-1
- Chemical Name:
- KIRA-7
- Synonyms
- KIRA-7;KIRA7,KIRA 7;Urea, N-[4-[8-amino-3-(1-methylcyclopropyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-(3-fluorophenyl)-
- CBNumber:
- CB94844964
- Molecular Formula:
- C27H23FN6O
- Molecular Weight:
- 466.51
- MDL Number:
- MFCD34469344
- MOL File:
- 1937235-76-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
KIRA-7 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0087229 | KIRA-7 99.09% | 1937235-76-1 | 5mg | $444 | 2026-06-04 | Buy |
| ChemScene | CS-0087229 | KIRA-7 99.09% | 1937235-76-1 | 10mg | $726 | 2026-06-04 | Buy |
| ChemScene | CS-0087229 | KIRA-7 99.09% | 1937235-76-1 | 25mg | $1452 | 2026-06-04 | Buy |
| ChemScene | CS-0087229 | KIRA-7 99.09% | 1937235-76-1 | 50mg | $2329 | 2026-06-04 | Buy |
| ChemScene | CS-0087229 | KIRA-7 99.09% | 1937235-76-1 | 100mg | $3792 | 2026-06-04 | Buy |
KIRA-7 Chemical Properties, Uses, Production
Uses
KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect[1].
in vivo
KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment results in decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. Likewise, mRNA levels of BiP and CHOP are significantly elevated after Bleomycin exposure, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment[1].
| Animal Model: | C57BL6 mice (12 weeks of age) with Bleomycin (1.5 units/kg)[1] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 14 days |
| Result: | Resulted in decreased spliced XBP1 and ATF4. Likewise, mRNA levels of BiP and CHOP were significantly decreased. |
References
[1] Thamsen M, et al. Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019 Jan 9;14(1):e0209824. DOI:10.1371/journal.pone.0209824
KIRA-7 Preparation Products And Raw materials
Raw materials
Preparation Products
KIRA-7 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 959 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
