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2,5-Dichloropyridine

2,5-Dichloropyridine Structure
2,5-Dichloropyridine structure
CAS No.
16110-09-1
Chemical Name:
2,5-Dichloropyridine
Synonyms
Dichloropyridine;4-Aminophenylacetamide;2,5- twochlorine pyridine;5-Dichloropyridine;2,5-Chloro pyridine;2,5-DICHLORPYRIDINE;2,5-dichloro-pyridin;2,5-DICHLOROPYRIDINE;2,5-Dichiloropyridine;Pyridine, 2,5-dichloro-
CBNumber:
CB9487592
Molecular Formula:
C5H3Cl2N
Molecular Weight:
147.99
MDL Number:
MFCD00006239
MOL File:
16110-09-1.mol
Last updated:2026-01-13 11:27:03
Product description Number Pack Size Price
2,5-Dichloropyridine 98% 193763 10g $40.4
2,5-Dichloropyridine 98% 193763 50g $129
2,5-Dichloropyridine >99.0%(GC) D1607 5g $46
2,5-Dichloropyridine >99.0%(GC) D1607 25g $113
2,5-Dichloropyridine D436155 50g $305
More product size
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2,5-Dichloropyridine Properties

Melting point 59-62 °C (lit.)
Boiling point 190-191 °C
Density 1.5159 (rough estimate)
refractive index 1.5500 (estimate)
Flash point 112 °C
storage temp. Inert atmosphere,Room Temperature
pka -2.25±0.10(Predicted)
form Crystalline Solid
color White to slightly yellow
Water Solubility insoluble
BRN 108886
InChI InChI=1S/C5H3Cl2N/c6-4-1-2-5(7)8-3-4/h1-3H
InChIKey GCTFDMFLLBCLPF-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C(Cl)C=C1
CAS DataBase Reference 16110-09-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII FZ623S5E22
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-37/39-36
RIDADR  UN2811
WGK Germany  3
RTECS  US8225000
Hazard Note  Harmful
HazardClass  IRRITANT
HazardClass  6.1
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2,5-Dichloropyridine price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 193763 2,5-Dichloropyridine 98% 16110-09-1 10g $40.4 2025-07-31 Buy
Sigma-Aldrich 193763 2,5-Dichloropyridine 98% 16110-09-1 50g $129 2023-06-20 Buy
TCI Chemical D1607 2,5-Dichloropyridine >99.0%(GC) 16110-09-1 5g $46 2025-07-31 Buy
TCI Chemical D1607 2,5-Dichloropyridine >99.0%(GC) 16110-09-1 25g $113 2025-07-31 Buy
TRC D436155 2,5-Dichloropyridine 16110-09-1 50g $305 2021-12-16 Buy
Product number Packaging Price Buy
193763 10g $40.4 Buy
193763 50g $129 Buy
D1607 5g $46 Buy
D1607 25g $113 Buy
D436155 50g $305 Buy

2,5-Dichloropyridine Chemical Properties,Uses,Production

Uses

2,5-Dichloropyridine is a reagent used in chemical synthesis. It has been used to synthesize 4-benzodiazepine-2,5 diones as Hdm2 antagonists and inhibitors of ERK protein kinase.

Chemical Properties

white to slightly yellow crystalline solid

Uses

2,5-Dichloropyridine was used in the synthesis of 6-halo-pyridin-3-yl boronic acids and esters. It undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.

Synthesis Reference(s)

Synthetic Communications, 20, p. 2971, 1990 DOI: 10.1080/00397919008051514

General Description

2,5-Dichloropyridine undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.

Synthesis

2,5-Dibromopyridine

624-28-2

2,5-Dichloropyridine

16110-09-1

General procedure for the synthesis of 2,5-dichloropyridine from 2,5-dibromopyridine: Catalyst 1 (10 mol%), 2,5-dibromopyridine (1.0 mmol), tetramethylammonium chloride (Me4NCl, 2.0 mmol), and ethanol (EtOH, 2.0 mL) were added to a Schlenk tube under nitrogen protection. Schlenk tubes were sealed using polytetrafluoroethylene (Teflon) valves and the reaction mixture was stirred at 100 °C. The reaction process was monitored by gas chromatography (GC) analysis. After completion of the reaction, the solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent ratio petroleum ether/ethyl acetate = 10:1) to give 2,5-dichloropyridine. The yield of the product was determined by high-resolution gas chromatography-mass spectrometry (GC-MS) analysis and the structure was confirmed by comparing its physical properties and spectral data with known compounds.

References

[1] Applied Catalysis A: General, 2014, vol. 472, p. 178 - 183
[2] Chemical Communications, 2012, vol. 48, # 76, p. 9468 - 9470

2,5-Dichloropyridine Preparation Products And Raw materials

Raw materials

Sodium sulfate Sodium chloride 3-Chloropyridine 3-Chloroperoxybenzoic acid Trimethylamine
Benzenesulfonyl chloride Dichloromethane Sulfuric acid 3-CHLOROPYRIDINE N-OXIDE 3,4-Dichloropyridine
2,3-Dichloropyridine

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Preparation Products

2,5-Dichloroisonicotinic acid 2,5-DICHLORO-4-FORMYLPYRIDINE 2-Bromo-5-chloropyridine 5-Chloropyridine-2-thiol 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID
2,5-DICHLORO-3-IODOPYRIDINE 2,5-Dichloro-4-iodopyridine 5-Chloropyridine-2-carboxylic acid 4-Piperidinol, 1-[6-(5'-chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl]-

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2,5-Dichloropyridine Suppliers

Global( 567)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13620 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Zjartschem 		+86-571 87238903 jocelynpan@zjarts.com CHINA 988 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29833 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2161 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Zjartschem 		58
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Shenzhen Nexconn Pharmatechs Ltd 		58

View Lastest Price from 2,5-Dichloropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,5-Dichloropyridine pictures 2026-01-26 2,5-Dichloropyridine
16110-09-1
 US $0.00-0.00 / kg 1kg 99%min 100kgs Shanghai Yongzeng Technology Co.,Ltd
2,5-Dichloropyridine pictures 2025-12-01 2,5-Dichloropyridine
16110-09-1
 US $0.00-0.00 / KG 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2,5-Dichloropyridine pictures 2025-11-18 2,5-Dichloropyridine
16110-09-1
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited

2,5-Dichloropyridine Spectrum

2,5-Dichloropyridine(16110-09-1)1HNMR2,5-Dichloropyridine(16110-09-1)FT-IR2,5-Dichloropyridine(16110-09-1)Raman2,5-Dichloropyridine(16110-09-1)IR

16110-09-1(2,5-Dichloropyridine)Related Search:

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2,5-Dimethylpyridine 2,3-DICHLOROPYRIDINE Methyl 2,3,5,6-tetrachloro-4-pyridyl sulfone Triclopyr Picloram
Chlorpyrifos 2,3,5,6-Tetrachloropyridine 2,6-Dichloropyridine Dichloropyridine,98% 2,3,5,6-Tetrachloropyridine-4-thiol
Pentachloropyridine 2,3,5-Trichloropyridine Clopyralid

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2,5-Dichloropyridine, 98% 5GR 2,5- twochlorine pyridine 2,5-Dichiloropyridine 2,5-Chloro pyridine 2,5-dichloro-pyridin 2,5-DICHLORPYRIDINE 2,5-Dichloropyridine97% Dichloropyridine 4-Aminophenylacetamide 2,5-DICHLOROPYRIDINE 2,5-DICHLOROPYRIDINE Pyridine, 2,5-dichloro- 2,5-Dichloropyridine,98% 2,5-dibrochloropyridine 5-Dichloropyridine 2,5-DICHLOROPYRIDINE 2,5-Dichloropyridine> 2,5-Dichloropyridine ISO 9001：2015 REACH 16110-09-1 1611-09-1 16110-09-01 240-278-2 26452-80-3 HETERO CHLORIDE Building Blocks Chloropyridines Halopyridines Pyridines Halogenated Heterocycles Heterocyclic Building Blocks Chlorinated heterocyclic series Pyridines, Pyrimidines, Purines and Pteredines Halides Pyridines Chloropyridines Halopyridines Boronic Acid C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridine pyridine derivative Building Blocks C5 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks alkyl chloride bc0001