1-(3-Bromo-2-hydroxyphenyl)ethanone
- CAS No.
- 1836-05-1
- Chemical Name:
- 1-(3-Bromo-2-hydroxyphenyl)ethanone
- Synonyms
- 2-Acetyl-6-broMophenol;3'-Bromo-2'-hydroxyacetophenone;3’-Bromo-2’-hydroxyacetophenone;3'-Bromo-2'-hydroxyacetophenone97%;1-(3-Bromo-2-hydroxyphenyl)ethanone;3'-Bromo-2'-hydroxyacetophenone 97%;Ethanone, 1-(3-broMo-2-hydroxyphenyl)-;1-(3-Bromo-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-6-bromophenol
- CBNumber:
- CB9489248
- Molecular Formula:
- C8H7BrO2
- Molecular Weight:
- 215.04
- MDL Number:
- MFCD08236725
- MOL File:
- 1836-05-1.mol
- MSDS File:
- SDS
| Melting point | 33°C |
|---|---|
| Boiling point | 252.3±25.0 °C(Predicted) |
| Density | 1.586±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 8.63±0.10(Predicted) |
| form | solid |
| color | Light beige |
| InChI | InChI=1S/C8H7BrO2/c1-5(10)6-3-2-4-7(9)8(6)11/h2-4,11H,1H3 |
| InChIKey | XPYYOCANFXTCKX-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=CC(Br)=C1O)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2914790090 |
1-(3-Bromo-2-hydroxyphenyl)ethanone price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS38516 | 1-(3-Bromo-2-hydroxyphenyl)ethanone 97% | 1836-05-1 | 1g | $29 | 2026-06-04 | Buy |
| Apolloscientific | OR54360 | 3'-Bromo-2'-hydroxyacetophenone 98% | 1836-05-1 | 1g | $37 | 2026-06-04 | Buy |
| Apolloscientific | OR54360 | 3'-Bromo-2'-hydroxyacetophenone 98% | 1836-05-1 | 5g | $90 | 2026-06-04 | Buy |
| Activate Scientific | AS38516 | 1-(3-Bromo-2-hydroxyphenyl)ethanone 97% | 1836-05-1 | 5g | $93 | 2026-06-04 | Buy |
| Activate Scientific | AS38516 | 1-(3-Bromo-2-hydroxyphenyl)ethanone 97% | 1836-05-1 | 25g | $311 | 2026-06-04 | Buy |
1-(3-Bromo-2-hydroxyphenyl)ethanone Chemical Properties, Uses, Production
Preparation
Preparation by diazotization of 5-amino-3-bromo-2- hydroxyacetophenone, followed by hydrolysis of the obtained diazonium salt (49%).
Synthesis
1829-37-4
1836-05-1
GENERAL STEPS: A solution of commercially available 2-bromophenol (10.0 g, 57.8 mmol) in anhydrous dichloromethane (50 mL) was added to a round-bottomed flask, followed by dropwise addition of acetyl chloride (5.0 g, 63.6 mmol) and triethylamine (4.67 mL, 63.6 mmol). The reaction mixture was stirred at room temperature for 1 h. The solvent was removed by distillation under reduced pressure to give pure 2'-bromophenyl acetate (12.18 g, 56.6 mmol, 98% yield). The resulting ester was dissolved in 1,2-dichlorobenzene (100 mL) and aluminum trichloride (11.3 g, 84.9 mmol) was added. The reaction mixture was heated to 140 °C and stirred for 3 hours. Upon completion of the reaction, it was adjusted to slightly acidic (pH) by adding ice and 10% hydrochloric acid. The organic phase was separated and the aqueous phase was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, dried with magnesium sulfate and filtered. Dichloromethane was removed by evaporation under reduced pressure. The crude product was treated with hexane (300 mL) and cooled at -20 °C to crystallize most of the para-substituted by-products, which were removed by filtration. The filtrate was filtered through a silica gel column and washed with hexane to remove 1,2-dichlorobenzene, followed by replacement of the eluent with dichloromethane-triethylamine (20:1). After separation by column chromatography, the eluate was evaporated under reduced pressure to afford the pure product 1-(3-bromo-2-hydroxyphenyl)ethanone (8) as a colorless oil (7.55 g, 35.1 mmol, 62% yield). The product was analyzed by IR, 1H NMR, 13C NMR and mass spectrometry to confirm the structure.
References
[1] Synthesis (Germany), 2016, vol. 48, # 1, p. 97 - 102
[2] Monatshefte fuer Chemie, 1965, vol. 96, p. 450 - 460
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 7, p. 909 - 913
[4] Organic Letters, 2016, vol. 18, # 15, p. 3766 - 3769
1-(3-Bromo-2-hydroxyphenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanijing m&m biotechnology Co. ,Ltd. | 025-87782433 18021532344 | 1345332203@qq.com | China | 4226 | 58 |
| Shijiazhuang Lickon PharmaTech Co., Ltd. | 031185291771 13832391721 | yaofeng2005@163.com | China | 947 | 58 |
| Suzhou Chenke Biotech Co., Ltd. | 18662408853 | 2120408911@qq.com | China | 980 | 55 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Beijing Eternalchem Co,. Ltd. | 010-59484199 18611897322;18611897322; | sales@eternalchem.com | China | 1993 | 60 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
View Latest Price from 1-(3-Bromo-2-hydroxyphenyl)ethanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-15 | 1-(3-BROMO-2-HYDROXYPHENYL)ETHANONE
1836-05-1
|
$1.00 | 1g | 99% | 1000KGS | Career Henan Chemical Co |
-
- 1-(3-BROMO-2-HYDROXYPHENYL)ETHANONE
1836-05-1
- $1.00
- 99%
- Career Henan Chemical Co
1836-05-1 (1-(3-Bromo-2-hydroxyphenyl)ethanone) Related Search:
1of4
