Cyclin A2 (BF683) Mouse mAb

Source

Mouse

Reactivity

Human

Background

While overcoming the G1/S checkpoint to commence DNA replication requires cyclin E, and traversing the G2/M checkpoint to initiate mitosis requires cyclin B to be present, cyclin A seems to be required for both S-phase and M-phase. A number of studies have described the ability of overexpressed cyclin A to accelerate the G1 to S transition, causing DNA replication, and cyclin A antisense DNA can prevent DNA replication. Cyclin A availability is apparently the rate-limiting step for entry into mitosis, and cyclin A is required for the completion of prophase. At late prophase, cyclin A may no longer be necessary as cdc2/cyclinB1 becomes active.

References

[1] Pagano, M. et al. (1992) EMBO. J. 11, 961-71.
[2] Resnitzky, D. et al. (1995) Mol. Cell. Biol. 15, 4347-52.
[3] d'Urso, G. et al. (1990) Science 250, 786-91.
[4] Zindy, F. et al. (1992) Biochem. Biophys. Res. Commun. 182, 1144-54.
[5] Furuno, N. et al. (1999) J. Cell. Biol. 147, 295-306.

Raw materials

Preparation Products