STOP (175) Mouse mAb

Source

Mouse

Reactivity

Human;Mouse;Rat

Background

Stable Tubule Only Polypeptide is a microtubule-associated protein, and its microtubule-stabilizing activity is regulated by calmodulin. STOPs have several tissue- and developmental-specific isoforms that are encoded by a single gene. Neurons express N-STOP and E-STOP, fibroblasts express F-STOP, oligodendrocytes express O-STOP, and astrocytes A-STOP. STOPs are the major contributors stabilizing microtubules that resist depolymerization due to cold or depolymerizing drugs. STOP knock-out mice display impaired synaptic plasticity associated with severe behavioral disorders in contrast to the anticipated neuronal development and brain anatomy defects.

References

[1] Bosc, C. et al. (1996) Proc Natl Acad Sci USA 93, 2125-30.
[2] Bosc, C. et al. (2001) J Biol Chem 276, 30904-13.
[3] Galiano, M.R. et al. (2004) J Neurosci Res 78, 329-37.
[4] Andrieux, A. et al. (2002) Genes Dev 16, 2350-64.

Raw materials

Preparation Products