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ChemicalBook >> CAS DataBase List >>E3 ligase Ligand-Linker Conjugates 50

E3 ligase Ligand-Linker Conjugates 50

E3 ligase Ligand-Linker Conjugates 50 Structure
E3 ligase Ligand-Linker Conjugates 50 structure
CAS No.
2271036-44-1
Chemical Name:
E3 ligase Ligand-Linker Conjugates 50
Synonyms
Poma-PEG1-N3;Pomalidomide-PEG1-C2-N3;Pomalidomide 4'-PEG1-azide;Cereblon Ligand-Linker Conjugates 13;E3 ligase Ligand-Linker Conjugates 50;Pomalidomide-PEG1-C2-azide;4-[2-(2-azidoethoxy)ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
CBNumber:
CB96127047
Molecular Formula:
C17H18N6O5
Molecular Weight:
386.37
MDL Number:
MFCD32197214
MOL File:
2271036-44-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 19:39:08
Product description Number Pack Size Price
Pomalidomide-PEG1-C2-N3 WQD03644 100mg $918
Pomalidomide-PEG1-C2-N3 ≥98% CS-0101170 25mg $185
Pomalidomide-PEG1-C2-N3 ≥98% CS-0101170 25mg $185
Pomalidomide-PEG1-C2-N3 bp-40497 25MG $320
Pomalidomide-PEG1-C2-N3 bp-40497 50MG $540
Request For Quotation

E3 ligase Ligand-Linker Conjugates 50 Properties

storage temp. -20°C, stored under nitrogen
form Solid
color Light yellow to yellow
InChIKey NJPMWHWTBBYBDY-UHFFFAOYSA-N
SMILES [N-]=[N+]=NCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
UNSPSC Code 12352125
NACRES NA.21

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

E3 ligase Ligand-Linker Conjugates 50 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth WQD03644 Pomalidomide-PEG1-C2-N3 2271036-44-1 100mg $918 2026-06-05 Buy
ChemScene CS-0101170 Pomalidomide-PEG1-C2-N3 ≥98% 2271036-44-1 25mg $185 2026-06-04 Buy
ChemScene CS-0101170 Pomalidomide-PEG1-C2-N3 ≥98% 2271036-44-1 25mg $185 2026-06-04 Buy
BroadPharm bp-40497 Pomalidomide-PEG1-C2-N3 2271036-44-1 25MG $320 2026-05-24 Buy
BroadPharm bp-40497 Pomalidomide-PEG1-C2-N3 2271036-44-1 50MG $540 2026-05-24 Buy
Product number Packaging Price Buy
WQD03644 100mg $918 Buy
CS-0101170 25mg $185 Buy
CS-0101170 25mg $185 Buy
bp-40497 25MG $320 Buy
bp-40497 50MG $540 Buy

E3 ligase Ligand-Linker Conjugates 50 Chemical Properties,Uses,Production

Uses

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1]. Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Biological Activity

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].

IC 50

Cereblon

storage

Store at -20°C

References

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.

E3 ligase Ligand-Linker Conjugates 50 Preparation Products And Raw materials

Raw materials

Preparation Products

E3 ligase Ligand-Linker Conjugates 50 Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39039 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13482353728 sales@fdc-chemical.com China 10000 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1639 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 025-86755008 17751752005 hszhang@bestfluorodrug.com China 2358 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 021-58461859 15821823057 service@aiviche.com China 49312 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 54995 58
Zhengzhou Convergence Chemical Co. LTD 13393710386 3941078109@qq.com China 9823 58
Hubei Kele Fine Chemical Co., Ltd 027-59101668 19945030958 2223443625@qq.com China 8000 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
SHANGHAI FDC-CHEMICAL CO.,LTD 58
Jilin Province Woda Biotechnology Co., Ltd. 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
Zhengzhou Convergence Chemical Co. LTD 58
Hubei Kele Fine Chemical Co., Ltd 58

View Lastest Price from E3 ligase Ligand-Linker Conjugates 50 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pomalidomide-PEG1-C2-N3 pictures 2026-05-11 Pomalidomide-PEG1-C2-N3
2271036-44-1
 $45.00 10g TargetMol Chemicals Inc.

2271036-44-1(E3 ligase Ligand-Linker Conjugates 50)Related Search:

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Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]- Pomalidomide-PEG3-N3 Pomalidomide-PEG6-butyl iodide E3 Ligase Ligand-Linker Conjugates 21 E3 ligase Ligand-Linker Conjugates 13
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate E3 ligase Ligand-Linker Conjugates 4 E3 ligase Ligand-Linker Conjugates 6 E3 Ligase Ligand-Linker Conjugates 19 E3 Ligase Ligand-Linker Conjugates 22
Pomalidomide-PEG5-CO2H POMALIDOMIDE-PEG2-CO2H E3 ligase Ligand-Linker Conjugates 7 Free Base

1of4

E3 ligase Ligand-Linker Conjugates 50 Cereblon Ligand-Linker Conjugates 13 Pomalidomide-PEG1-C2-N3 4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione Poma-PEG1-N3 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- 4-[2-(2-azidoethoxy)ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Pomalidomide 4'-PEG1-azide Pomalidomide-PEG1-C2-azide 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione 2271036-44-1