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Nebivolol hydrochloride

Nebivolol hydrochloride Structure
Nebivolol hydrochloride structure
CAS No.
152520-56-4
Chemical Name:
Nebivolol hydrochloride
Synonyms
Bystolic;CS-496;D06622;R-67555;Nebilox;Nebilet;Lobivon;Nebivolo;Narbivolol;NEBIVOLOL HC
CBNumber:
CB9649567
Molecular Formula:
C22H26ClF2NO4
Molecular Weight:
441.9
MDL Number:
MFCD07357273
MOL File:
152520-56-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Product description Number Pack Size Price
Nebivolol hydrochloride CRS, European Pharmacopoeia (EP) Reference Standard Y0002299 35 mg $632
Nebivolol hydrochloride ≥98% (HPLC) N1915 10mg $90.5
Nebivolol Hydrochloride pharmaceutical secondary standard, certified reference material PHR3059 300mg $638
Nebivolol hydrochloride United States Pharmacopeia (USP) Reference Standard 1457833 150mg $2390
Nebivolol Hydrochloride >98.0%(HPLC) N0954 20mg $71
More product size
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Nebivolol hydrochloride Properties

Melting point 220-222°C
storage temp. room temp
solubility DMSO: ≥20mg/mL
form powder
color white to off-white
Merck 14,6432
Major Application pharmaceutical
InChIKey JWEXHQAEWHKGCW-JBFWKIBUNA-N
SMILES [C@H]([C@@]1([H])CCC2=CC(F)=CC=C2O1)(O)CNC[C@@H]([C@]1([H])CCC2=CC(F)=CC=C2O1)O.Cl |&1:0,1,17,18,r|
FDA UNII JGS34J7L9I
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H413
Precautionary statements  P501-P273-P270-P264-P301+P312+P330
Hazard Codes  Xn,N
Risk Statements  22-50/53
Safety Statements  60-61
RIDADR  3077
WGK Germany  3
HS Code  29322090
Storage Class 11 - Combustible Solids
NFPA 704
0
3 0

Nebivolol hydrochloride price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0002299 Nebivolol hydrochloride CRS, European Pharmacopoeia (EP) Reference Standard 152520-56-4 35 mg $632 2026-04-30 Buy
Sigma-Aldrich N1915 Nebivolol hydrochloride ≥98% (HPLC) 152520-56-4 10mg $90.5 2026-04-30 Buy
Sigma-Aldrich PHR3059 Nebivolol Hydrochloride pharmaceutical secondary standard, certified reference material 152520-56-4 300mg $638 2026-04-30 Buy
Sigma-Aldrich 1457833 Nebivolol hydrochloride United States Pharmacopeia (USP) Reference Standard 152520-56-4 150mg $2390 2026-04-30 Buy
TCI Chemical N0954 Nebivolol Hydrochloride >98.0%(HPLC) 152520-56-4 20mg $71 2026-04-30 Buy
Product number Packaging Price Buy
Y0002299 35 mg $632 Buy
N1915 10mg $90.5 Buy
PHR3059 300mg $638 Buy
1457833 150mg $2390 Buy
N0954 20mg $71 Buy

Nebivolol hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Powder

Uses

Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM

Uses

Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.

Uses

A -Adrenergic blocker. Used as an antihypertensive

Definition

ChEBI: (R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride.

Biological Activity

Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo .

Biochem/physiol Actions

Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.

storage

Desiccate at RT

Nebivolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Nebivolol hydrochloride Suppliers

Global( 442)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Qiangshan New Material Co.,Ltd.
+86-13951653990 jjx35259720@hotmail.com China 27 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5998 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2451 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +86-15383190639 admin@86-ss.com China 996 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 736 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
HubeiwidelychemicaltechnologyCo.,Ltd 		18627774460 faith@widelychemical.com CHINA 738 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14320 58
Supplier Advantage
Nanjing Qiangshan New Material Co.,Ltd.
58
Wuhan Fortuna Chemical Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
career henan chemical co 		58
HubeiwidelychemicaltechnologyCo.,Ltd 		58
Standardpharm Co. Ltd. 		58

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View Lastest Price from Nebivolol hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nebivolol hydrochloride pictures 2026-08-14 Nebivolol hydrochloride
152520-56-4
 0.99 RongNa Biotechnology Co.,Ltd
Nebivolol hydrochloride pictures 2026-08-14 Nebivolol hydrochloride
152520-56-4
 $800.00-990.00 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Nebivolol hydrochloride pictures 2026-08-14 Nebivolol hydrochloride
152520-56-4
 1g 98%-102% 10KGS WUHAN FORTUNA CHEMICAL CO., LTD

Nebivolol hydrochloride Spectrum

Nebivolol hydrochloride(152520-56-4)1HNMR

152520-56-4(Nebivolol hydrochloride)Related Search:

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AROTINOLOL HCL Esmolol hydrochloride Methylene Blue

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Narbivolol rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride Nebivolol hydrochloride, >=98% RAC NEBIVOLOL, HYDROCHLORIDE a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride Lobivon Nebilet Nebilox R-67555 NEBIVOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE) a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride Nebivolol hydrochloride NEBIVOLOL HC R 065824 hydrochloride CS-496 a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] (aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride D06622 Nebivolol hydrochloride (usan) (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol) Nebivolol (Bystolic) Nebivalate HCl 2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-(±)- Nebivolol hydrochloride, 98%, a selective β1 antagonist NebivololHydrochloride> Nebivolol reference substance Nebivolol hydrochloride USP/EP/BP Nebivolol hydrochlorider Nebivolol hydrochloride Impurities Nebivolo Nebivolol Hcl- IP Nebivolol HCl (R 065824) R-Nebivolol D4 HCl Nebivolol HydrochlorideQ: What is Nebivolol Hydrochloride Q: What is the CAS Number of Nebivolol Hydrochloride Q: What is the storage condition of Nebivolol Hydrochloride TIANFU CHEM--Nebivolol hydrochloride Nebivolol Hydrochloride (1457833) Nebivolol hydrochloride salt 2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α'R,2R,2'S)-rel- (αR,α'R,2R,2'S)-rel-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-Benzopyran-2-methanol hydrochloride (1:1) Nebivolol hydrochloride (R-65824) Hexamidine 2-hydroxyethansulfanonate R 065824 hydrochloride|||Nebivolol HCl|||R-65824 (S)-1-((R)-6-fluorochroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethanol hydrochloride Nebivolol hydrochloride in methanol Nebivolol hydrochloride, beta1 antagonist Nebivolol hydrochloride, 10 mM in DMSO Nebivolol HCl - Bio-X ? Nebivolol Hydrochloride 98% (αR,α'R,2R,2'S)-rel-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride Nebivolo RRRR/Nebivolol HCl Nebivolol hydrochlor Bystolic 152520-56-4 C22H26ClF2NO4 C22H25F2NO4HCl C22H25F2NO4ClH C22H23O4F2NHCL