3-Amino-2(1H)-pyridinone
- CAS No.
- 33630-99-8
- Chemical Name:
- 3-Amino-2(1H)-pyridinone
- Synonyms
- 3-Amino-2-pyridinone;3-Amino-2-pyridone;3-Amino-2-pyridinol;3-AMINO-PYRIDIN-2-OL;3-Amino-2-pyridone >3-Amino-2-pyridinol,97%;3-Amino-2(1H)-pyridinone;3-amino-1H-pyridin-2-one;3-Amino-2-hydroxypyridine;2-HYDROXY-3-AMINO PYRIDINE
- CBNumber:
- CB9664184
- Molecular Formula:
- C5H6N2O
- Molecular Weight:
- 110.11
- MDL Number:
- MFCD03411556
- MOL File:
- 33630-99-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-amino-2-hydroxypyridine AldrichCPR | CDS007860 | 250MG | $114 |
| 3-Amino-2-pyridone >96.0%(GC)(T) | A2285 | 1g | $104 |
| 3-Amino-2-pyridone >96.0%(GC)(T) | A2285 | 5g | $415 |
| 3-Amino-2-hydroxypyridine | A611160 | 10g | $525 |
| 3-Aminopyridin-2(1H)-one | 4H56-1-VP | 100g | $949 |
| More product size | |||
| Melting point | 118-130 °C |
|---|---|
| Boiling point | 206.4°C (rough estimate) |
| Density | 1.2111 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 13.87±0.10(Predicted) |
| form | Powder |
| color | Dark brown to black |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C5H6N2O/c6-4-2-1-3-7-5(4)8/h1-3H,6H2,(H,7,8) |
| InChIKey | VTSFNCCQCOEPKF-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=CC=C1N |
| CAS DataBase Reference | 33630-99-8(CAS DataBase Reference) |
| FDA UNII | ER85UN5LYN |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Amino-2(1H)-pyridinone price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS007860 | 3-amino-2-hydroxypyridine AldrichCPR | 33630-99-8 | 250MG | $114 | 2026-04-30 | Buy |
| TCI Chemical | A2285 | 3-Amino-2-pyridone >96.0%(GC)(T) | 33630-99-8 | 1g | $104 | 2026-04-30 | Buy |
| TCI Chemical | A2285 | 3-Amino-2-pyridone >96.0%(GC)(T) | 33630-99-8 | 5g | $415 | 2026-04-30 | Buy |
| TRC | A611160 | 3-Amino-2-hydroxypyridine | 33630-99-8 | 10g | $525 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-VP | 3-Aminopyridin-2(1H)-one | 33630-99-8 | 100g | $949 | 2021-12-16 | Buy |
3-Amino-2(1H)-pyridinone Chemical Properties,Uses,Production
Uses
3-Amino-2-hydroxypyridine has been used as a reactant in the preparation of benzothiazolyl hydroxyindolinylphenyl ureas as potent P2Y1 antagonists.
Chemical Properties
Brown to off-white crystalline powder.
Uses
It is used as pharmaceutical intermediate. It is involved in synthesis of functionalized pyrido[4,3-b][1,4]oxazine and imidazo[1,2-a]pyridine derivatives. The use of ethyl 2-chloro-3-oxopropanoate with 2-amino-3-hydroxypyridine or 3-amino-4-hydroxypyridine led, respectively, to imidazo[1,2-a]pyridine derivatives or ethyl pyrido[4,3-b][1,4] oxazine-2-carboxylate.
Synthesis
6332-56-5
33630-99-8
a) Synthesis of 3-aminopyridin-2-ol: In a 500 mL three-necked flask, 3-nitropyridin-2(1H)-one (1 g, 7.14 mmol) was dissolved in methanol (200 mL), followed by addition of 10% palladium/activated carbon catalyst (100 mg, 10 wt%). The reaction mixture was stirred for 3 h under hydrogen atmosphere (1 atm) and at room temperature (25°C). Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad, and the filtrate was concentrated under reduced pressure by rotary evaporator to afford the white solid product 3-aminopyridin-2-ol (800 mg, quantitative yield). Product characterization data: 1H-NMR (CD3OD, 300 MHz) δ 6.78-6.73 (m, 2H), 6.23 (t, J = 6.5 Hz, 1H); MS (ESI) m/z 111.1 [M+H]+.
References
[1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 14
[2] Patent: WO2006/51410, 2006, A1. Location in patent: Page/Page column 46
[3] Heterocycles, 1990, vol. 31, # 12, p. 2201 - 2204
[4] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 1013,1024
3-Amino-2(1H)-pyridinone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Nanjing Fred Technology Co., Ltd. | +86-02584696168 15380713688 | Austin@fredchem.cn | CHINA | 865 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
View Lastest Price from 3-Amino-2(1H)-pyridinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 3-Amino-2(1H)-pyridinone
33630-99-8
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-10-15 | 3-Amino-2(1H)-pyridinone
33630-99-8
|
US $10.00 / KG | 1KG | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2019-07-14 | 3-Amino-2-pyridinol
33630-99-8
|
US $1.00 / KG | 1KG | 90%-99.9% | 500kg | Career Henan Chemical Co |
-
- 3-Amino-2(1H)-pyridinone
33630-99-8
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 3-Amino-2(1H)-pyridinone
33630-99-8
- US $10.00 / KG
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- 3-Amino-2-pyridinol
33630-99-8
- US $1.00 / KG
- 90%-99.9%
- Career Henan Chemical Co
