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4-Fluorophenol

CAS No.
371-41-5
Chemical Name:
4-Fluorophenol
Synonyms
Fluorophenol;P-FLUOROPHENOL;FPO;p-Fluorphenol;p-Fluorohenol;4-Fluorphenol;4-FLUOROPHENOL;P-flrorophenol;4-fluoro-pheno;p-fluoro-pheno
CBNumber:
CB9672628
Molecular Formula:
C6H5FO
Molecular Weight:
112.1
MDL Number:
MFCD00002316
MOL File:
371-41-5.mol
MSDS File:
SDS
Last updated:2026-04-10 10:27:34
Product description Number Pack Size Price
4-Fluorophenol 99% F13207 25g $50.2
4-Fluorophenol 99% F13207 100g $113
4-Fluorophenol >99.0%(GC) F0160 25g $31
4-Fluorophenol >99.0%(GC) F0160 500g $305
p-Fluorophenol, 99% 09-4090 25g $52
More product size

4-Fluorophenol Properties

Melting point 43-46 °C (lit.)
Boiling point 185 °C (lit.)
Density 1.22
Flash point 155 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 80g/l
pka 9.89(at 25℃)
form Crystalline Solid
color Yellow-beige to pink
PH 5.4 (H2O, 20℃)(saturated aqueous solution)
Water Solubility 50 g/L
BRN 1362752
Henry's Law Constant 1.4×101 mol/(m3Pa) at 25℃, Abraham et al. (1994)
Stability Stable. Flammable. Incompatible with strong oxidizing agents.
InChI 1S/C6H5FO/c7-5-1-3-6(8)4-2-5/h1-4,8H
InChIKey RHMPLDJJXGPMEX-UHFFFAOYSA-N
SMILES Oc1ccc(F)cc1
Dissociation constant 0 at 27℃
CAS DataBase Reference 371-41-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII K6DT6TR5E5
NIST Chemistry Reference Phenol, 4-fluoro-(371-41-5)
EPA Substance Registry System Phenol, 4-fluoro- (371-41-5)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,C,T,F+
Risk Statements  20/21/22-36/37/38-52/53
Safety Statements  26-37/39-61-36
RIDADR  UN 2928 6.1/PG 2
WGK Germany  1
RTECS  SL4550000
10-23
Hazard Note  Corrosive/Harmful
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29081000
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Irrit. 2
Skin Irrit. 2
NFPA 704
2
2 0

4-Fluorophenol price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F13207 4-Fluorophenol 99% 371-41-5 25g $50.2 2026-03-19 Buy
Sigma-Aldrich F13207 4-Fluorophenol 99% 371-41-5 100g $113 2026-03-19 Buy
TCI Chemical F0160 4-Fluorophenol >99.0%(GC) 371-41-5 25g $31 2026-03-19 Buy
TCI Chemical F0160 4-Fluorophenol >99.0%(GC) 371-41-5 500g $305 2026-03-19 Buy
Strem Chemicals 09-4090 p-Fluorophenol, 99% 371-41-5 25g $52 2024-03-01 Buy
Product number Packaging Price Buy
F13207 25g $50.2 Buy
F13207 100g $113 Buy
F0160 25g $31 Buy
F0160 500g $305 Buy
09-4090 25g $52 Buy

4-Fluorophenol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluorophenol is a fluorinated phenolic compound with various applications as a starting reagent for synthesizing pharmaceuticals. It is a widely used intermediate in the industrial production of several drugs, including cisapride and Sabeluzole by Janssen, Sorbinil by Pfizer, and Progabide by Synthelabo.

Definition

ChEBI: 4-fluorophenol is a fluorophenol that is phenol in which the hydrogen para- to the hydroxy group has been replaced by a fluorine. It is a fluorophenol and a member of monofluorobenzenes. It is used as an intermediate in the production of liquid crystals.

Preparation

Acetyl hypofluorite also will fluoro-demetallate benzene derivatives, for example mercury derivatives of phenol gave 4-fluorophenol.
synthesis of 4-Fluorophenol

Synthesis Reference(s)

Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8

Hazard

Irritant.

1765-93-1
371-41-5
Synthesis of 4-Fluorophenol from 4-Fluorobenzeneboronic acid
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View Lastest Price from 4-Fluorophenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Fluorophenol pictures 2025-12-01 4-Fluorophenol
371-41-5
US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
4-Fluorophenol pictures 2025-09-25 4-Fluorophenol
371-40-5
US $9.00-0.90 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
4-Fluorophenol pictures 2025-09-25 4-Fluorophenol
371-41-5
US $9.00-0.90 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
  • 4-Fluorophenol pictures
  • 4-Fluorophenol
    371-41-5
  • US $0.00 / kg
  • 99%
  • Shaanxi Dideu New Materials Co. Ltd
  • 4-Fluorophenol pictures
  • 4-Fluorophenol
    371-40-5
  • US $9.00-0.90 / KG
  • 99%
  • Henan Fengda Chemical Co., Ltd
  • 4-Fluorophenol pictures
  • 4-Fluorophenol
    371-41-5
  • US $9.00-0.90 / KG
  • 99%
  • Henan Fengda Chemical Co., Ltd
p-Fluorphenol Phenol, p-fluoro- 4-FLUOROPHENOL AKOS BBS-00004253 P-FLUOROPHENOL Fluorophenoloffwhiteflakes p-Fluorophenol,99% Phenol, 4-fluoro- 4-Fluorophenol,99% 4-Fluorphenol p-Fluorohenol 4-Fluorophenol, 99% 25GR P-flrorophenol p-Hydroxyfluorobenzene Of fluorophenol 4-FLUOROPHENOL GR FOR ANALYSIS Phenol, p-fluoro- (6CI,8CI) The fluorine phenol 4-Fluorophenyl alcohol 4-fluoro-Phenol p-Fluoro phenol p-fluoro-pheno 4-fluoro-pheno Fluorophenol p-fluoro-pheno 4-Fluorophenol> 4-Fluorophenol, 99%, for synthesis FPO 4 - fluorine phenol 4-Fluorophenol ISO 9001:2015 REACH 4-Fluorophenol, GR 99% 4-Fluorophenol pure, 98% Para Fluoro Phenol (PFP) 4-Fluorophenol, 98% Maralixibat Impurity 15 371-41-5 371-40-5 372-20-4 FC6H4OH Building Blocks for Liquid Crystals Phenols (Building Blocks for Liquid Crystals) ALCOHOL Puriss p.a. Phenols Oxygen Compounds General Use Organic Building Blocks Analytical Chromatography Product Catalog Building Blocks Analytical Reagents alcohol| alkyl Fluorine organofluorine compounds Pyridines Aryl Fluorinated Building Blocks Building Blocks C6 to C8 Chemical Synthesis Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks