5-BROMO-6-METHOXYPYRIDIN-2-AMINE
- CAS No.
- 1211533-83-3
- Chemical Name:
- 5-BROMO-6-METHOXYPYRIDIN-2-AMINE
- Synonyms
- 5-BROMO-6-METHOXYPYRIDIN-2-AMINE;5-Bromo-6-methoxy-2-pyridinamine;2-Pyridinamine, 5-bromo-6-methoxy-;5-Bromo-6-methoxy-pyridin-2-ylamine
- CBNumber:
- CB9701977
- Molecular Formula:
- C6H7BrN2O
- Molecular Weight:
- 203.04
- MDL Number:
- MFCD08062947
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-BROMO-6-METHOXYPYRIDIN-2-AMINE price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | LYB53383 | 5-Bromo-6-methoxypyridin-2-amine | 1211533-83-3 | 5g | $354 | 2026-06-04 | Buy |
| Biosynth | LYB53383 | 5-Bromo-6-methoxypyridin-2-amine | 1211533-83-3 | 50g | $1770 | 2026-06-04 | Buy |
| Activate Scientific | AS42008 | 5-Bromo-6-methoxypyridin-2-amine 98% | 1211533-83-3 | 1g | $75 | 2026-06-04 | Buy |
| Activate Scientific | AS42008 | 5-Bromo-6-methoxypyridin-2-amine 98% | 1211533-83-3 | 5g | $371 | 2026-06-04 | Buy |
| Synthonix | B17534 | 5-bromo-6-methoxypyridin-2-amine 97.0% | 1211533-83-3 | 100mg | $25 | 2026-05-06 | Buy |
5-BROMO-6-METHOXYPYRIDIN-2-AMINE Chemical Properties,Uses,Production
Synthesis
67-56-1
89284-11-7
1211533-83-3
The general procedure for the synthesis of 2-amino-5-bromo-6-methoxypyridine from methanol and 5,6-dibromopyridin-2-amine was as follows: sodium metal (1.8 g, 78.2 mmol) was added in small portions to dry methanol (70 mL) at -20 °C. The resulting solution was stirred at 0 °C for 4 hours. Subsequently, the reaction mixture was transferred to a sealed tube, 5,6-dibromopyridin-2-amine (Example 7a, 10 g, 39.8 mmol) was added and heated at 120 °C for 24 hours. After completion of the reaction, the solvent was removed under reduced pressure and the residue was diluted with water. The aqueous phase was neutralized with 2 M HCl and then extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by fast column chromatography using a gradient elution with a hexane solution of 5% to 15% acetone to afford the target product 2-amino-5-bromo-6-methoxypyridine (6.6 g, 82% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.91 (s, 3H), 4.31 (br. s., 2H), 5.99 (d, 1H), 7.48 (d, 1H). esms m/z 202.8, 204.8 [M + H]+.
References
[1] Patent: US2012/122843, 2012, A1. Location in patent: Page/Page column 15
[2] Patent: WO2015/109109, 2015, A1. Location in patent: Paragraph 0711
[3] Patent: US2017/44182, 2017, A1. Location in patent: Paragraph 0983
5-BROMO-6-METHOXYPYRIDIN-2-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanijing m&m biotechnology Co. ,Ltd. | 025-87782433 18021532344 | 1345332203@qq.com | China | 4226 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Record Tech (Shanghai) Co., LTD | 13761627472 | 183009664@qq.com | China | 661 | 62 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4538 | 58 |
| Xi'an NewProChem Co.,Ltd. | 15332490153 | newprochem@126.com | China | 991 | 55 |
