Dexamethasone-17-acetate
- CAS No.
- 1177-87-3
- Chemical Name:
- Dexamethasone-17-acetate
- Synonyms
- DEXAMETHASONE ACETATE;DEXAMETHASON ACETATE;DEXAMETHASONE 21-ACETATE;9-fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate;Dectan;Panasone;Dectancyl;NSC 39471;Decadronal;Decadron-la
- CBNumber:
- CB9703269
- Molecular Formula:
- C24H31FO6
- Molecular Weight:
- 434.5
- MDL Number:
- MFCD00027407
- MOL File:
- 1177-87-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Dexamethasone acetate European Pharmacopoeia (EP) Reference Standard | D0710000 | 150 mg | $244 |
| Dexamethasone acetate United States Pharmacopeia (USP) Reference Standard | 1176506 | 200mg | $501 |
| Dexamethasone 21-acetate VETRANAL | 46166 | 100mg | $81.7 |
| Dexamethasone Acetate ≥98% | 22286 | 100mg | $37 |
| Dexamethasone Acetate ≥98% | 22286 | 500mg | $132 |
| More product size | |||
| Melting point | 238-240 °C(lit.) |
|---|---|
| alpha | D25 +73° (chloroform) (Arth, 1958); D +77.6° (Oliveto) |
| Boiling point | 579.4±50.0 °C(Predicted) |
| Density | 1.1517 (estimate) |
| vapor pressure | <0.0000001 kPa ( 25 °C) |
| refractive index | 87 ° (C=1, Dioxane) |
| storage temp. | 2-8°C |
| solubility | Soluble at 100 mg/ml in acetone |
| pka | 12.08±0.70(Predicted) |
| form | Powder |
| color | White |
| biological source | synthetic |
| Water Solubility | 13mg/L(25 ºC) |
| Merck | 2943 |
| BRN | 2342608 |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | AKUJBENLRBOFTD-RPRRAYFGSA-N |
| SMILES | [H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O |
| CAS DataBase Reference | 1177-87-3(CAS DataBase Reference) |
| FDA UNII | K7V8P532WP |
| NIST Chemistry Reference | Prednisolone, 9alpha-fluoro-16alpha-methyl-, acetate(1177-87-3) |
| EPA Substance Registry System | Dexamethasone-21-acetate (1177-87-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| Hazard Codes | Xi |
| Risk Statements | 43 |
| Safety Statements | 36/37 |
| WGK Germany | 3 |
| RTECS | TU4050000 |
| TSCA | TSCA listed |
| HS Code | 29372290 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Repr. 1B |
Dexamethasone-17-acetate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D0710000 | Dexamethasone acetate European Pharmacopoeia (EP) Reference Standard | 1177-87-3 | 150 mg | $244 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1176506 | Dexamethasone acetate United States Pharmacopeia (USP) Reference Standard | 1177-87-3 | 200mg | $501 | 2026-04-30 | Buy |
| Sigma-Aldrich | 46166 | Dexamethasone 21-acetate VETRANAL | 1177-87-3 | 100mg | $81.7 | 2022-05-15 | Buy |
| Cayman Chemical | 22286 | Dexamethasone Acetate ≥98% | 1177-87-3 | 100mg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 22286 | Dexamethasone Acetate ≥98% | 1177-87-3 | 500mg | $132 | 2026-04-30 | Buy |
Dexamethasone-17-acetate Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Originator
Dexacen,Central,US,1977
Uses
Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.
Uses
Dexamethasone has many uses in the treatment of cancer. Dexamethasone relieves inflammation in various parts of the body. To treat or prevent allergic reactions. As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and other lung conditions. As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple myeloma. It is also used for replacement therapy in adrenal insufficiency and in a screening test for the diagnosis of cushing's syndrome. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.
Uses
Dexamethasone acetate is used as a pharmaceutical primary standard to quantify the analyte in pharmaceutical formulations using chromatography ttechniques.
Definition
ChEBI: Dexamethasone acetate is a corticosteroid hormone.
Manufacturing Process
The preparation of dexamethasone acetate is described in US Patent
3,007,923 as follows. 1.5 cc of dimethylformamide and 1.5 cc of anhydrous
hydrofluoric acid are admixed and treated with 480 mg of 9β,11β-epoxy-17αhydroxy-21-acetoxy-16α-methyl-1,4-pregnadiene-3,20-dione (prepared
according to E.P. Oliveto et al, J. Am. Chem. Soc., 80, 44331, 1958). The
steroid dissolves in about 15 minutes. The reaction mixture is shaken for two
hours at a temperature between 0 and +5°C, and then poured into 75 cc of
water containing in suspension, 7.5 grams of sodium bicarbonate. The mixture
is vacuum filtered, the filter cake washed and then dried at 100°C, yielding
460 mg of crude hexadecadrol contaminated with a small amount of the
starting material. A single recrystallization from methylene chloride yields 370
mg of the pure product having a melting point of 170°C and 229°C. The
mother liquor yields 62 mg of the starting material, and a remainder
constituting a mixture of starting and final materials with little other
contamination.
brand name
Decadron (Merck).
Therapeutic Function
9-Fluoro-11β,17-dihydroxy-21-acetoxy-16α-methylpregna1,4-diene-3,20-dione
Safety Profile
Experimental teratogenic and reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F-.
Purification Methods
Dexamethasone 21-acetate is purified on neutral Al2O3 using CHCl3 as eluent, the fractions are evaporated, and the residue is recrystallised from CHCl3. It has max at 239nm. [Oliveto et al. J Am Chem Soc 8 0 4431 1958]. [Beilstein 8 IV 3501.]
Dexamethasone-17-acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Wuhan JiyunZen Tech Co., Ltd. | +86-18062099985 | Amyjiyunzen@yeah.net | China | 672 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
View Lastest Price from Dexamethasone-17-acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | Dexamethasone-17-acetate
1177-87-3
|
US $0.00 / g | 100g | 99.0% | 50kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-04-23 | Dexamethasone acetate
1177-87-3
|
US $44.00 / mg | 99.65% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-23 | Dexamethasone acetate
1177-87-3
|
US $44.00 / mg | 99.65% | 10g | TargetMol Chemicals Inc. |
-
- Dexamethasone-17-acetate
1177-87-3
- US $0.00 / g
- 99.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Dexamethasone acetate
1177-87-3
- US $44.00 / mg
- 99.65%
- TargetMol Chemicals Inc.
-
- Dexamethasone acetate
1177-87-3
- US $44.00 / mg
- 99.65%
- TargetMol Chemicals Inc.
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