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Pheniramine maleate

Pheniramine maleate Structure
Pheniramine maleate structure
CAS No.
132-20-7
Chemical Name:
Pheniramine maleate
Synonyms
Pheneramine Maleate;PHENIRAMINE MALEATE SALT;pm241;Fervex;daneral;ho11513;inhiston;Trimetose;205-051-4;Antolozine
CBNumber:
CB9727768
Molecular Formula:
C20H24N2O4
Molecular Weight:
356.42
MDL Number:
MFCD00079250
MOL File:
132-20-7.mol
Last updated:2026-01-20 19:14:41
Product description Number Pack Size Price
Pheniramine Maleate Pharmaceutical Secondary Standard; Certified Reference Material PHR2646 300MG $216
Pheniramine maleate salt P6902 5g $167
Pheniramine maleate European Pharmacopoeia (EP) Reference Standard P0850000 250 mg $164
Pheniramine maleate United States Pharmacopeia (USP) Reference Standard 1522301 150mg $425
Pheniramine Maleate >98.0%(HPLC)(T) P2271 25g $139
More product size
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Pheniramine maleate Properties

Melting point 104-108°C
Boiling point 489.25°C (rough estimate)
Density 1.2233 (rough estimate)
refractive index 1.6800 (estimate)
storage temp. 2-8°C
solubility Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
form Solid
color White
Water Solubility >=1 g/100 mL at 24 ºC
λmax 262nm(lit.)
Merck 14,7235
Stability Stable. Incompatible with strong oxidizing agents.
Major Application pharmaceutical (small molecule)
InChI InChI=1S/C16H20N2.C4H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;5-3(6)1-2-4(7)8/h3-10,12,15H,11,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey SSOXZAQUVINQSA-BTJKTKAUSA-N
SMILES C(CCN(C)C)(C1C=CC=CN=1)C1C=CC=CC=1.C(/C(=O)O)=C/C(=O)O
FDA 21 CFR 310.545; 341.12
CAS DataBase Reference 132-20-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII NYW905655B
EPA Substance Registry System Pheniramine maleate (132-20-7)
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  UT0175000
TSCA  TSCA listed
HS Code  2933399090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral

Pheniramine maleate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2646 Pheniramine Maleate Pharmaceutical Secondary Standard; Certified Reference Material 132-20-7 300MG $216 2025-07-31 Buy
Sigma-Aldrich P6902 Pheniramine maleate salt 132-20-7 5g $167 2025-07-31 Buy
Sigma-Aldrich P0850000 Pheniramine maleate European Pharmacopoeia (EP) Reference Standard 132-20-7 250 mg $164 2025-07-31 Buy
Sigma-Aldrich 1522301 Pheniramine maleate United States Pharmacopeia (USP) Reference Standard 132-20-7 150mg $425 2025-07-31 Buy
TCI Chemical P2271 Pheniramine Maleate >98.0%(HPLC)(T) 132-20-7 25g $139 2025-07-31 Buy
Product number Packaging Price Buy
PHR2646 300MG $216 Buy
P6902 5g $167 Buy
P0850000 250 mg $164 Buy
1522301 150mg $425 Buy
P2271 25g $139 Buy

Pheniramine maleate Chemical Properties,Uses,Production

Chemical Properties

white powder

Originator

Trimeton Maleate, Schering ,US,1948

Uses

Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.

Definition

ChEBI: Pheniramine maleate is an organic molecular entity.

Manufacturing Process

According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the Pheniramine, BP 139°-142°C/1-2 mm. The Pheniramine maleate is produced by reaction with maleic acid.

Therapeutic Function

Antihistaminic

General Description

Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts.

General Description

White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.

Air & Water Reactions

Water soluble.

Reactivity Profile

Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible.

Biochem/physiol Actions

Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.

Side effects

Drowsiness, dizziness, dry mouth/nose/throat, headache, upset stomach, constipation, or trouble sleeping may occur. 

References

[1] Patent: CN108164455, 2018, A. Location in patent: Paragraph 0009; 0010; 0058; 0059; 0060; 0062

Pheniramine maleate Preparation Products And Raw materials

Raw materials

POTASSIUM AMIDE Maleic acid 2-Benzylpyridine Pheniramine

Preparation Products

Pheniramine maleate Suppliers

Global( 405)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8753 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21599 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29833 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8619521488211 info@longyupharma.com China 2541 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Hebei Lihe Biotechnology Co.,ltd 		86-311-80292533 13315122300 sales@lihebiotech.com CHINA 298 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
Hebei Lihe Biotechnology Co.,ltd 		58

Related articles

View Lastest Price from Pheniramine maleate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pheniramine maleate pictures 2026-01-23 Pheniramine maleate
132-20-7
 US $0.00 / KG 1KG 98%min 100KG WUHAN FORTUNA CHEMICAL CO., LTD
Pheniramine maleate pictures 2026-01-20 Pheniramine maleate
132-20-7
 US $73.00-34.00 / mg 99.85% 10g TargetMol Chemicals Inc.
Pheniramine maleate pictures 2026-01-20 Pheniramine maleate
132-20-7
 US $73.00-34.00 / mg 99.85% 10g TargetMol Chemicals Inc.

Pheniramine maleate Spectrum

Pheniramine maleate(132-20-7)1HNMR

132-20-7(Pheniramine maleate)Related Search:

Trimebutine maleate Pheniramine Maleic acid Chlorphenamine maleate PHENYL VALERATE
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Brompheniramine PHENYL RESIN Phenylacetic acid

1of4

PROPHENPYRIDAMINE MALEATE PHENIRAMINE MALEATE PHENIRAMINE MALEATE SALT inhiston n,n-dimethyl-gamma-phenyl-2-pyridinepropanamin(z)-2-butenedioate(1:1) pheniraminehydrogenmaleate phenyl(2-pyridyl)(beta-n,n-dimethylaminomethyl)methanemaleate pm241 trimetonmaleate 1-phenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate 2-[ALPHA-(2-DIMETHYLAMINOETHYL) BENZYL]PYRIDINE MALEATE SALT But-2-enedioic acid N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine Pyridine, 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1) Trimetose N,N-Dimethyl-3-phenyl-3-(2-pyridyl)propane-1-amine·maleic acid HeniraMine Maleate Pheniramine Maleate (150 mg) 2-[α-[2-(DiMethylaMino)ethyl]benzyl]pyridine Maleate Antolozine Fervex N,N-DiMethyl-γ-phenyl-2-pyridinepropanaMine (2Z)-2-Butenedioate 2-Pyridinepropanamine, N,N-dimethyl-γ-phenyl-, (2Z)-2-butenedioate (1:1) 2-Pyridinepropanamine, N,N-dimethyl-.gamma.-phenyl-, (2Z)-2-butenedioate (1:1) PHENIRAMINEMALEATE,BP Pheneramine Maleate 205-051-4 4-CYANO PRYIDINE (PHENIRAMINE MALEATE) dimethyl-[3-phenyl-3-(2-pyridin-1-iumyl)propyl]ammonium Dexchlorpheniramine Impurity 1 (Dexchlorpheniramine EP Impurity A) PHENIRAMIN MALEATE 1-(n,n-dimethylamino)-3-(phenyl-3-alpha-pyridyl)propanemaleate 2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine,bimaleate 2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine,maleate 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1) avil-retard daneral ho11513 Chlorpheniramine Impurity G Pheniramine maleate CRS Pheniramine maleate USP/EP/BP N,N-dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate Pheniramine maleateQ: What is Pheniramine maleate Q: What is the CAS Number of Pheniramine maleate Q: What is the storage condition of Pheniramine maleate Q: What are the applications of Pheniramine maleate Pheniramine Maleate (1522301) (3RS)-N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine (Pheniramine) Pheniramine Maleate （Dexchlorpheniramine EP Impurity A Maleate Salt） Brompheniramine Maleate EP Impurity C as Maleate Dexchlorpheniramine Maleate EP Impurity A as Maleate Dextrochlorobenzamine maleate EP impurity A Maleic acid fenfluramine Pheniramine maleate - Bio-X ? Pheniramine Maleate 98% Pipradrol 4-Isomer) 1.0 mg/ml in Methanol d,l-Pheniramine.maleate d,l-Pheniramine.maleate, 1mg/ml in Methanol (as free base) Dexchlorpheniramine Impurity 1 132-20-7 C16H20N2C4H4O4 H1 histamine receptor antagonist.