2-Bromo-4-fluorobenzonitrile
- CAS No.
- 36282-26-5
- Chemical Name:
- 2-Bromo-4-fluorobenzonitrile
- Synonyms
- Bromo-4-fluorobenzonitrile;2-BROMO-4-FLUOROBENZONITRILE;Benzonitrile, 2-broMo-4-fluoro-;2-Bromo-4-fluorobenzonitrile98%;2-Bromo-4-fluorobenzonitrile >2-Bromo-4-fluorobenzonitrile 98%
- CBNumber:
- CB9732074
- Molecular Formula:
- C7H3BrFN
- Molecular Weight:
- 200.01
- MDL Number:
- MFCD00672924
- MOL File:
- 36282-26-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 77-78°C |
|---|---|
| Boiling point | 262.4±25.0 °C(Predicted) |
| Density | 1.69±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | White to Gray to Brown |
| BRN | 1940597 |
| InChI | InChI=1S/C7H3BrFN/c8-7-3-6(9)2-1-5(7)4-10/h1-3H |
| InChIKey | MNNDREXLRLDWEY-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(F)C=C1Br |
| CAS DataBase Reference | 36282-26-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | T,Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-36/37/39-36/37-26-9 | |||||||||
| RIDADR | 3439 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Bromo-4-fluorobenzonitrile price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 736031 | 2-Bromo-4-fluorobenzonitrile 97% | 36282-26-5 | 25g | $165 | 2023-06-20 | Buy |
| TCI Chemical | B2744 | 2-Bromo-4-fluorobenzonitrile >98.0%(GC) | 36282-26-5 | 5g | $26 | 2026-04-30 | Buy |
| TCI Chemical | B2744 | 2-Bromo-4-fluorobenzonitrile >98.0%(GC) | 36282-26-5 | 25g | $71 | 2026-04-30 | Buy |
| Usbiological | 265667 | 2-Bromo-4-fluorobenzonitrile Asreported | 36282-26-5 | 25g | $389 | 2026-06-03 | Buy |
| Usbiological | 265667 | 2-Bromo-4-fluorobenzonitrile Asreported | 36282-26-5 | 50g | $593 | 2026-06-03 | Buy |
2-Bromo-4-fluorobenzonitrile Chemical Properties, Uses, Production
Chemical Properties
Off-white to light yellow powder
Uses
2-Bromo-4-fluorobenzonitrile is used as a starting material to prepare 3-benzoyl-4-bromo-2-fluorobenzonitrile via metalation with tmpZnCl·LiCl and subsequent benzoylation[3]. 2-Bromo-4-fluorobenzonitrile serves as a model substrate for photodriven dehalogenation and undergoes light-activated reductive dehalogenation with anion radical materials such as DPBT−• and reduced MOF structures[4].
Synthesis
59142-68-6
36282-26-5
General procedure for the synthesis of 2-bromo-4-fluorobenzonitrile from 2-bromo-4-fluorobenzaldehyde: In a dry 2 mL reaction vial, 2-bromo-4-fluorobenzaldehyde (3a, 0.136 g, 1 mmol, 1 eq.) and pyridine (0.474 g, 6.0 mmol, 6 eq.) were added followed by the addition of acetonitrile (2 mL) to make the concentration of 3a to be 0.5 M. Next, to the reaction vial was added Ru(bpy)3(PF6)2 (0.017 g, 0.02 mmol, 0.02 eq.), 2 (0.043 g, 0.20 mmol, 0.20 eq.), (NH4)2S2O8 (0.501 g, 2.2 mmol, 2.2 eq.), and activated 3molecular sieves (~0.2 g). The reaction vial was sealed and placed in a blue LED reactor for 24 hours of irradiation. The temperature of the mixture was maintained at ~50 °C during the reaction without fan cooling. Upon completion of irradiation, the reaction was quenched with EtOAc and the mixture was transferred to a dispensing funnel. Additional EtOAc (30 mL) and 0.5 M HCl (aq, 30 mL) were added to separate the organic and aqueous layers. The aqueous layer was extracted with EtOAc (3 × 20 mL), and the combined organic layers were washed sequentially with 0.5 M HCl (aq, 2 × 20 mL), saturated aqueous NaHCO3 (2 × 20 mL), and brine (20 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude product. The crude product was adsorbed on silica gel (the amount of silica gel was 1.5 times the weight of the theoretical product) and gently loaded onto a silica gel column. The target product was first rinsed with excess hexane (about 5 times the volume of the column), and then eluted with a hexane/EtOAc solvent mixture (3-4 times the volume of the column) with a volume ratio of 90:10. The eluate was concentrated by rotary evaporation to give pure 2-bromo-4-fluorobenzonitrile (3c, 0.066 g, 50% yield) as a white solid.
References
[1] Synlett, 2018, vol. 29, # 16, p. 2185 - 2190
[2] Organic and Biomolecular Chemistry, 2018, vol. 16, # 42, p. 7959 - 7963
[3]Bresser, T., Monzon, G., Mosrin, M., & Knochel, P. (2010). Scaleable Preparation of Sensitive Functionalized Aromatics and Heteroaromatics via Directed Metalation Using tmpZnCl·LiCl. Organic Process Research & Development, 14(6), 1299–1303. https://doi.org/10.1021/op1001935
[4]Wang, X., Islam, T., Gobeze, H. B., Barboza-Ramos, I., Fahim, A. M. M., Lawton, J., Duvva, N., Tomlinson, A. L., & Schanze, K. S. (2025). Consecutive Photoinduced Electron Transfer in a Donor–Acceptor–Donor Chromophore and Corresponding Metal Organic Frameworks. ACS Applied Materials & Interfaces, 17(22), 32260–32270. https://doi.org/10.1021/acsami.5c02627
2-Bromo-4-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from 2-Bromo-4-fluorobenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | 2-Bromo-4-fluorobenzonitrile
36282-26-5
|
$1.00 | 100g | 98%min | Career Henan Chemical Co |
-
- 2-Bromo-4-fluorobenzonitrile
36282-26-5
- $1.00
- 98%min
- Career Henan Chemical Co
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