Nafamostat mesylate
- CAS No.
- 82956-11-4
- Chemical Name:
- Nafamostat mesylate
- Synonyms
- FUTHAN;FUT-175;CS-128;Coahibitor;nafamstatmesilate;Nafamostat mesila;Nafomastatmesilate;Nafamstat mesylate;Nafmostat mesylate;NAFAMOSTAT MESYLATE
- CBNumber:
- CB9764794
- Molecular Formula:
- C21H25N5O8S2
- Molecular Weight:
- 539.58
- MDL Number:
- MFCD00941430
- MOL File:
- 82956-11-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Nafamostat mesylate ≥98% (HPLC) | N0289 | 10MG | $171 |
| Nafamostat mesylate ≥98% (HPLC) | N0289 | 50MG | $676 |
| Nafamostat Mesylate >98.0%(HPLC) | N0959 | 20mg | $61 |
| Nafamostat Mesylate >98.0%(HPLC) | N0959 | 100mg | $203 |
| Nafamostat (mesylate) ≥98% | 14837 | 5mg | $37 |
| More product size | |||
| Melting point | 259-261°C |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in Water (up to 25 mg/ml). |
| form | powder |
| color | white to beige |
| Merck | 14,6350 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at 4°C for up to 1 month, or at -80°C for up to 6 months. |
| InChI | 1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4) |
| InChIKey | SRXKIZXIRHMPFW-UHFFFAOYSA-N |
| SMILES | CS(O)(=O)=O.CS(O)(=O)=O.C(OC1=CC=C2C(=C1)C=CC(C(=N)N)=C2)(=O)C1=CC=C(NC(N)=N)C=C1 |
| CAS DataBase Reference | 82956-11-4(CAS DataBase Reference) |
| FDA UNII | 1D2T74921W |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361fd | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | nwg | |||||||||
| RTECS | DG2736000 | |||||||||
| HS Code | 29252900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Repr. 2 | |||||||||
| NFPA 704 |
|
Nafamostat mesylate price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N0289 | Nafamostat mesylate ≥98% (HPLC) | 82956-11-4 | 10MG | $171 | 2026-03-19 | Buy |
| Sigma-Aldrich | N0289 | Nafamostat mesylate ≥98% (HPLC) | 82956-11-4 | 50MG | $676 | 2026-03-19 | Buy |
| TCI Chemical | N0959 | Nafamostat Mesylate >98.0%(HPLC) | 82956-11-4 | 20mg | $61 | 2026-03-19 | Buy |
| TCI Chemical | N0959 | Nafamostat Mesylate >98.0%(HPLC) | 82956-11-4 | 100mg | $203 | 2026-03-19 | Buy |
| Cayman Chemical | 14837 | Nafamostat (mesylate) ≥98% | 82956-11-4 | 5mg | $37 | 2024-03-01 | Buy |
Nafamostat mesylate Chemical Properties,Uses,Production
Description
Nafamostat mesylate is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement, anticoagulant, antikallikrein and other activities, and thus may have additional utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.
Chemical Properties
Tan to pale orange solid
Originator
Torii (Japan)
Uses
A non-peptide proteaseinhibitor.
Uses
Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma
brand name
FUTHAN
Biological Activity
Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
Biochem/physiol Actions
Nafamostat mesylate is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.
Synthesis
By p-guanidinobenzoic acid hydrochloride, 6-amidino groups-beta naphthal, 4,5-dicyano imidazole, methylene dichloride mix, 0-5 ℃ is stirred 1 hour, then improve temperature to 18-22 ℃, insulation reaction 8-12h, filters washed with dichloromethane, gained solid is 2 with methylsulfonic acid adjust pH, obtains nafamostat mesylate.
storage
Store at +4°C
Background
Nafamostat Mesylate, also known as FUT-175, is a potent and reversible, broad-spectrum serine protease inhibitor of trypsin, tryptase, and other additional proteases. This small compound has been identified as a key player in the disruption of the inflammatory response via inhibition of the complement system and coagulation cascade. Its wide range of inhibitory activity displays anti-cancer and anti-viral properties and has shown effective inhibition of MERS-CoV by preventing membrane fusion, making it a promising therapeutic candidate against the 2019-nCoV infection.
References
[1] XINXIN HAN. Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase activity[J]. Chemico-Biological Interactions, 2019, 297: Pages 80-84. DOI:10.1016/j.cbi.2018.10.023
Nafamostat mesylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19654 | 58 |
| Hebei Dangtong Import and export Co LTD | +86-86-4001020630 +8619831957301 | admin@hbdangtong.com | China | 1000 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 | da@zhongda-biotech.com | China | 232 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 193 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Wuhan JiyunZen Tech Co., Ltd. | +86-18062099985 | Amyjiyunzen@yeah.net | China | 672 | 58 |
Related articles
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- Nov 7，2025
View Lastest Price from Nafamostat mesylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | Nafamostat mesylate
82956-11-4
|
US $0.00-0.00 / g | 1g | 98.5～101.5% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-04-20 | Nafamostat mesylate
82956-11-4
|
US $37.00-85.00 / mg | 99.70% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-10 | Nafamostat mesylate
82956-11-4
|
US $5.00-0.50 / KG | 0.10000000149011612KG | 99% hplc | 5000kg | Wuhan JiyunZen Tech Co., Ltd. |
-
- Nafamostat mesylate
82956-11-4
- US $0.00-0.00 / g
- 98.5～101.5%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Nafamostat mesylate
82956-11-4
- US $37.00-85.00 / mg
- 99.70%
- TargetMol Chemicals Inc.
-
- Nafamostat mesylate
82956-11-4
- US $5.00-0.50 / KG
- 99% hplc
- Wuhan JiyunZen Tech Co., Ltd.
