Bis-Tris propane
- CAS No.
- 64431-96-5
- Chemical Name:
- Bis-Tris propane
- Synonyms
- B-T-Propane;1,3-BIS[TRIS(HYDROXYMETHYL)METHYLAMINO]PROPANE;yehebio;BIS-TRIS PROPANE;BIS-TRIS propane 99+%;BIS-Tris Propane, ULTROL;BIS-TRIS PROPANE SIGMAULTRA;1.0 M BIS-TRIS propane pH 8.5;1.0 M BIS-TRIS propane pH 6.6;1.0 M BIS-TRIS propane pH 8.4
- CBNumber:
- CB9769557
- Molecular Formula:
- C11H26N2O6
- Molecular Weight:
- 282.33
- MDL Number:
- MFCD00004689
- MOL File:
- 64431-96-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 164-165 °C(lit.) |
|---|---|
| Boiling point | 573.3±50.0 °C(Predicted) |
| Density | 1.326±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| form | Powder/Solid |
| color | White |
| PH | 9.0-10.1 (20-25℃, 1M in water) |
| pka | (1) 6.8, (2) 9.0(at 25℃) |
| PH Range | 6.3 - 9.5 |
| biological source | synthetic |
| Water Solubility | Soluble in water. |
| BRN | 1786109 |
| Major Application | diagnostic assay manufacturing |
| InChI | InChI=1S/C11H26N2O6/c14-4-10(5-15,6-16)12-2-1-3-13-11(7-17,8-18)9-19/h12-19H,1-9H2 |
| InChIKey | HHKZCCWKTZRCCL-UHFFFAOYSA-N |
| SMILES | C(NC(CO)(CO)CO)CCNC(CO)(CO)CO |
| CAS DataBase Reference | 64431-96-5(CAS DataBase Reference) |
| FDA UNII | N5YD0CS4DO |
| Absorption | ≤0.05 at 290 at 30% (w/w) |
| UNSPSC Code | 12161705 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29221980 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Bis-Tris propane price More Price(94)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHG0005 | BIS-TRIS propane | 64431-96-5 | 1KIT | $1930 | 2026-04-30 | Buy |
| Sigma-Aldrich | B6755 | BIS-TRIS propane ≥99.0% (titration) | 64431-96-5 | 10 kg | $7580 | 2026-04-30 | Buy |
| Sigma-Aldrich | B4679 | BIS-TRIS propane BioPerformance Certified, cell culture tested, ≥99.0% | 64431-96-5 | 25g | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | B4679 | BIS-TRIS propane BioPerformance Certified, cell culture tested, ≥99.0% | 64431-96-5 | 100g | $336 | 2026-04-30 | Buy |
| Sigma-Aldrich | 394111 | BIS-TRIS propane ULTROL® Grade, >98% (titration), non-zwitterionic buffer useful in pH range 6.3-9.5 | 64431-96-5 | 100 g | $258 | 2025-07-31 | Buy |
Bis-Tris propane Chemical Properties,Uses,Production
Description
BIS-TRIS Propane is Good′s buffer. It acts as ligand and forms series of dinuclear hydroxo complexes with Lanthanides(III) in the pH range 7-9. It is useful for diagnostic assay manufacturing industry.
Chemical Properties
White powder
Uses
BIS-Tris Propane is a buffer that is useful in the pH 6.3 - 9.5 range. This wide buffering range is due to its two pKa values, 6.8 (pKa1) and 9.0 (pKa2), being so close. Because of the wide buffering range, particularly down to pH 6 - 7, this buffer has been used to enhance the stability or activity of restriction enzymes, compared to Tris buffer (which is a poor buffer below pH 7.5 and has a comparatively large change in pKa with temperature).
Uses
BIS-TRIS Propane may be used in the following studies:
- As buffer to investigate the influence of anions with varying nucleophilic properties on the autoxidation of oxymyoglobin (MbO2).
- Purification of glucose-binding protein from membranes of Sulfolobus solfataricus.
- As buffer during GeO2 mineralisation.
Definition
ChEBI: Bis-tris propane is a water-soluble buffer substance used for the preparation of the biochemical and biological buffer solutions; pKa = 6.8 at 20 ℃. It has a role as a buffer. It is functionally related to a member of tris.
Precautions
This trihydroxyamine analog, also known as bis-tris propane, presents as a white to almost white crystalline powder. Store in a cool and dark place. 1,3-Bis[tris(hydroxymethyl)methylamino]propane is known to be incompatible with oxidizing agents and should not be handled in their vicinity.
Bis-Tris propane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Bingochem Co., Ltd. | 0571-87658025 | sales@bingochem.com | China | 21532 | 58 |
| Hunan Hengfei bio-pharmaceutical Co. , Ltd. | 0746-6222194 13874779848 | 57182844@qq.com | China | 52 | 58 |
| Wuhan haorong Biotechnology Co., Ltd | 13217229939 | 773651767@qq.com | China | 4498 | 58 |
| Zhengzhou Runkai Pharmaceutical Technology Co., Ltd | 19137644811 | 3649307081@qq.com | China | 496 | 58 |
| Jiangsu Boquan Biotechnology Co., Ltd. | 19709916022 | 5954981@qq.com | China | 2458 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
Related articles
- Bis-Tris Propane: Buffering Applications, CO2 Fixation Catalysis, and Wet Scrubbing Use
- Bis-Tris Propane acts as a versatile buffer, enhances CaI2-catalyzed CO2 fixation to cyclic carbonates, and works as a DMSO-ba....
- Oct 21,2025
View Lastest Price from Bis-Tris propane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![]() |
2026-09-11 | BIS-TRIS propane
64431-96-5
|
$10.00-204.00 | 25g | 0.99 | 25kg | Shanghai UCHEM Inc. | |
![]() |
2026-09-11 | Bis-Tris propane
64431-96-5
|
$666.00-999.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
![]() |
2026-09-11 | 1,3-Bis[tris(hydroxymethyl)methylamino]propane
64431-96-5
|
1KG | 99% | 3500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-

- BIS-TRIS propane
64431-96-5
- $10.00-204.00
- 0.99
- Shanghai UCHEM Inc.
-

- Bis-Tris propane
64431-96-5
- $666.00-999.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
![1,3-Bis[tris(hydroxymethyl)methylamino]propane pictures](/ProductImageEN/2021-09/Small/700fa58a-74c1-4e73-9075-592fb55f64db.jpg)
- 1,3-Bis[tris(hydroxymethyl)methylamino]propane
64431-96-5
- $0.00
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
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