N-(tert-Butoxycarbonyl)-2-aminoacetonitrile
- CAS No.
- 85363-04-8
- Chemical Name:
- N-(tert-Butoxycarbonyl)-2-aminoacetonitrile
- Synonyms
- Carbamic acid, (cyanomethyl)-, 1,1-dimethylethyl ester;AKOS 91568;BOC-GLY-NITRILE;N-Boc-aminoacetonitrile;BOC-2-AMINOACETONITRILE;N-BOC-2-Aminoacetonitrile;2-(Boc-aMino)acetonitrile;N-(ert-Butoxycarbonyl)-2-Aminoacetonitrile;N-(TERT-BUTOXYCARBONYL)-2-AMINOACETONITRILE;N-(cyanomethyl)carbamic acid tert-butyl ester
- CBNumber:
- CB9773604
- Molecular Formula:
- C7H12N2O2
- Molecular Weight:
- 156.18
- MDL Number:
- MFCD00239390
- MOL File:
- 85363-04-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| N-(tert-Butoxycarbonyl)-2-aminoacetonitrile 97% | 443050 | 5g | $63 |
| N-(tert-Butoxycarbonyl)-2-aminoacetonitrile 97% | 443050 | 25g | $169 |
| N-(tert-Butoxycarbonyl)-2-aminoacetonitrile >97% | OR926356 | 5g | $21 |
| N-(tert-Butoxycarbonyl)-2-aminoacetonitrile >97% | OR926356 | 25g | $26 |
| N-(tert-Butoxycarbonyl)-2-aminoacetonitrile >97% | OR926356 | 100g | $98 |
| More product size | |||
| Melting point | 53-57 °C(lit.) |
|---|---|
| Boiling point | 186 °C(lit.) |
| Density | 1.1832 (rough estimate) |
| refractive index | 1.4880 (estimate) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 9.96±0.46(Predicted) |
| form | solid |
| color | Brown |
| InChI | InChI=1S/C7H12N2O2/c1-7(2,3)11-6(10)9-5-4-8/h5H2,1-3H3,(H,9,10) |
| InChIKey | SMZKPZXYDDZDJG-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NCC#N |
| CAS DataBase Reference | 85363-04-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| HS Code | 2926907090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral |
N-(tert-Butoxycarbonyl)-2-aminoacetonitrile price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 443050 | N-(tert-Butoxycarbonyl)-2-aminoacetonitrile 97% | 85363-04-8 | 5g | $63 | 2023-06-20 | Buy |
| Sigma-Aldrich | 443050 | N-(tert-Butoxycarbonyl)-2-aminoacetonitrile 97% | 85363-04-8 | 25g | $169 | 2023-06-20 | Buy |
| Apolloscientific | OR926356 | N-(tert-Butoxycarbonyl)-2-aminoacetonitrile >97% | 85363-04-8 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR926356 | N-(tert-Butoxycarbonyl)-2-aminoacetonitrile >97% | 85363-04-8 | 25g | $26 | 2026-06-04 | Buy |
| Apolloscientific | OR926356 | N-(tert-Butoxycarbonyl)-2-aminoacetonitrile >97% | 85363-04-8 | 100g | $98 | 2026-06-04 | Buy |
N-(tert-Butoxycarbonyl)-2-aminoacetonitrile Chemical Properties,Uses,Production
Uses
N-(tert-Butoxycarbonyl)-2-aminoacetonitrile may be used for the preparation of N-(tert-butoxycarbonyl)-2-aminoacetamidoxime, by reaction with hydroxylamine hydrochloride.
General Description
N-(tert-Butoxycarbonyl)-2-aminoacetonitrile is an organic building block.
Synthesis
24424-99-5
151-63-3
85363-04-8
The general procedure for the synthesis of 2-(Boc-amino)acetonitrile from di-tert-butyl dicarbonate and aminoacetonitrile sulfate was as follows: first, 3 mmol of aminoacetonitrile sulfate was dissolved in 50 mL of anhydrous methanol at room temperature and protected by nitrogen. Subsequently, 770 mg (4.5 mmol) of L-cysteine methyl ester hydrochloride and 0.63 mL (4.5 mmol) of triethylamine were added to this solution. The reaction mixture was stirred at room temperature for 3 hours, after which the solvent was removed by rotary evaporation. The residue was dissolved in dichloromethane and washed sequentially with saturated sodium bicarbonate solution and brine. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated, and finally purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 5:1) to afford a methyl ester derivative of the target product 2-(Boc-amino)acetonitrile. Next, 0.9 mL (0.9 mmol) of a 1N lithium hydroxide solution was added to 1.0 mmol of a 5 mL methanol solution of the above methyl ester derivative at 0 °C. The suspension was stirred at room temperature for 1 h. Upon completion of the reaction, it was diluted with 20 mL of acetone to promote precipitation of the product. The white solid was collected by filtration and dried to give purified 2-(Boc-amino)acetonitrile.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 19, p. 6229 - 6232
[2] Chemistry - A European Journal, 2018, vol. 24, # 68, p. 18075 - 18081
N-(tert-Butoxycarbonyl)-2-aminoacetonitrile Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | sales@kindchem.cn | China | 1226 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Wuxi Rejoys chemical Technology Co., Ltd. | 0510-86103381 | sales@rejoyschem.com | CHINA | 976 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
View Lastest Price from N-(tert-Butoxycarbonyl)-2-aminoacetonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | N-(tert-Butoxycarbonyl)-2-aminoacetonitrile
85363-04-8
|
$7.00 | 1kg | 99% | 100kg | Career Henan Chemical Co | |
 |
2019-07-06 | N-(tert-Butoxycarbonyl)-2-aminoacetonitrile
85363-04-8
|
$7.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- N-(tert-Butoxycarbonyl)-2-aminoacetonitrile
85363-04-8
- $7.00
- 99%
- Career Henan Chemical Co
-
- N-(tert-Butoxycarbonyl)-2-aminoacetonitrile
85363-04-8
- $7.00
- 99%
- Career Henan Chemical Co
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