BAY-1797
- CAS No.
- 2055602-83-8
- Chemical Name:
- BAY-1797
- Synonyms
- BAY-1797;BAY-1797, 10 mM in DMSO;Benzeneacetamide, N-[3-(aminosulfonyl)-4-(3-chlorophenoxy)phenyl]-;paw,ion,inhibit,anti-inflammatory,CFA,Complete,P2XRs,BAY-1797,Freund’s,selective,channel,P2X Receptor,inflamed,Inhibitor,BAY1797,Adjuvant,BAY 1797,P2X,anti-nociceptive
- CBNumber:
- CB98022694
- Molecular Formula:
- C20H17ClN2O4S
- Molecular Weight:
- 416.88
- MDL Number:
- MOL File:
- 2055602-83-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| BAY-1797 ≥98% (HPLC) | SML2817 | 5 mg | $111 |
| BAY-1797 ≥98% (HPLC) | SML2817 | 25 mg | $356 |
| BAY-1797 ≥98% | 34229 | 5mg | $127 |
| BAY-1797 ≥98% | 34229 | 10mg | $227 |
| BAY-1797 ≥98% | 34229 | 25mg | $499 |
| Density | 1.414±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | Soluble in DMSO (>25 mg/ml) |
| pka | 9.84±0.60(Predicted) |
| form | solid |
| color | Pale brown |
| Stability | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | CSJYMAFXYMYNCK-UHFFFAOYSA-N |
| SMILES | ClC1=CC=CC(OC2=C(C=C(NC(CC3=CC=CC=C3)=O)C=C2)S(=O)(N)=O)=C1 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
BAY-1797 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2817 | BAY-1797 ≥98% (HPLC) | 2055602-83-8 | 5 mg | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2817 | BAY-1797 ≥98% (HPLC) | 2055602-83-8 | 25 mg | $356 | 2026-04-30 | Buy |
| Cayman Chemical | 34229 | BAY-1797 ≥98% | 2055602-83-8 | 5mg | $127 | 2026-04-30 | Buy |
| Cayman Chemical | 34229 | BAY-1797 ≥98% | 2055602-83-8 | 10mg | $227 | 2026-04-30 | Buy |
| Cayman Chemical | 34229 | BAY-1797 ≥98% | 2055602-83-8 | 25mg | $499 | 2026-04-30 | Buy |
BAY-1797 Chemical Properties,Uses,Production
Description
BAY-1797 (2055602-83-8) is a selective P2X4 receptor antagonist (IC50 = 211 nM HEK cellular assay; P2X4 calcium influx based assays – hIC50 = 108 nM, mIC50 = 112 nM, rIC50 = 233 nM).1 Displayed antinociceptive and anti-inflammatory effects in mouse CFA inflammatory pain models.
Uses
BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects[1].
in vivo
BAY-1797 (12.5-50 mg/kg; p.o.) shows a significant induction of PGE2 levels in the inflamed paw in the mouse Complete Freund’s Adjuvant (CFA) inflammatory pain model[1].
BAY-1797 (50 mg/kg; once daily for multiple p.o. administrations) induces a significant reduction of the ipsilateral paw load 24 and 48 h after CFA injection[1].
BAY-1797 treatment shows the AUCnorm, Vss and t1/2 are 1.06 kg h/L, 3.67 L/kg and 2.64 hours, respectively[1].
| Animal Model: | Female adult C57BL/6N mice (CFA inflammatory pain model)[1] |
| Dosage: | 12.5, 25, 50 mg/kg |
| Administration: | p.o.; once |
| Result: | Dose-dependently reduced PGE2 concentration in inflamed paw. |
| Animal Model: | Rat male Wistar[1] |
| Dosage: | 1 mg/kg |
| Administration: | i.v. (Pharmacokinetic Analysis) |
| Result: | The AUCnorm, Vss and t1/2 were 1.06 kg h/L, 3.67 L/kg and 2.64 hours, respectively. |
IC 50
P2X4 Receptor
storage
Store at -20°C
References
[1] STEFAN WERNER*. Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile[J]. Journal of Medicinal Chemistry, 2019, 62 24: 11194-11217. DOI:10.1021/acs.jmedchem.9b01304
BAY-1797 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY-1797 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9636 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4124 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Shaanxi Dideu New Materials Co. Ltd | 18192503167 | 1036@dideu.com | China | 13167 | 58 |
| Shanghai Hanhong Scientific Co., Ltd. | +undefined17612118332 | Lucky@hanhonggroup.com | China | 5842 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
View Lastest Price from BAY-1797 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-10 | BAY-1797
2055602-83-8
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-07-17 | BAY-1797
2055602-83-8
|
$34.00-129.00 | 98.74% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-17 | BAY-1797
2055602-83-8
|
$34.00-129.00 | 98.74% | 10g | TargetMol Chemicals Inc. |
