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ChemicalBook >> CAS DataBase List >>Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]-

Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]-

Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]- Structure
Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]- structure
CAS No.
1241280-25-0
Chemical Name:
Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]-
Synonyms
SAE-14;GPR183, 10 mM in DMSO;GPR183 antagonist SAE-14;Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]-;GPR183 antagonist-1,SAE-14,inhibit,SAE 14,SAE14,HL-60,GPR183,Inhibitor,GPR183 antagonist SAE-14,EBI2/GPR183
CBNumber:
CB98236002
Molecular Formula:
C19H19F3N2O2
Molecular Weight:
364.36
MDL Number:
MOL File:
1241280-25-0.mol
Last updated:2025-09-12 14:32:05
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Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]- Properties

Boiling point 560.6±50.0 °C(Predicted)
Density 1.321±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C)
form Solid
pka 13.59±0.70(Predicted)
color White to off-white

Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]- Chemical Properties,Uses,Production

Uses

SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice[1].

in vivo

SAE-14 (compound SAE-14) (i.th.; 2.9 μM; once) can reverse nerve injury-induced allodynia in mice[1].

Animal Model:Male and female ICR mice[1]
Dosage:2.9 μM
Administration:intrathecal (i.th.) injections; 2.9 μM; once
Result:Reversed CCI-induced mechanical allodynia in a time-dependent manner.

References

[1] Kathryn Braden, et al. GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375. DOI:10.1124/jpet.120.000105

Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]- Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39031 58
Nantong Hi-Future Biotechnology Co., Ltd 18051384581 sales@chemhifuture.com China 3210 58
Hubei wei shi reagent group ltd., company 027-59102966 18717199209 2853877583@qq.com China 2539 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24989 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2680 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5840 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 025-58851090 17714375163 2881759498@qq.com China 13011 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Nantong Hi-Future Biotechnology Co., Ltd 58
Hubei wei shi reagent group ltd., company 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 58

View Lastest Price from Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SAE-14 pictures 2025-09-11 SAE-14
1241280-25-0
 US $58.00-238.00 / mg 99.85% 10g TargetMol Chemicals Inc.
  • SAE-14 pictures
  • SAE-14
    1241280-25-0
  • US $58.00-238.00 / mg
  • 99.85%
  • TargetMol Chemicals Inc.

Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]- Spectrum

Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]-(1241280-25-0)1HNMR
Benzenepropanamide, 3,4-difluoro-N-[3-fluoro-5-(4-morpholinyl)phenyl]- GPR183 antagonist-1,SAE-14,inhibit,SAE 14,SAE14,HL-60,GPR183,Inhibitor,GPR183 antagonist SAE-14,EBI2/GPR183 GPR183 antagonist SAE-14 GPR183, 10 mM in DMSO SAE-14 1241280-25-0