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1-(2-METHYLPYRIDIN-4-YL)ETHANONE

1-(2-METHYLPYRIDIN-4-YL)ETHANONE Structure
1-(2-METHYLPYRIDIN-4-YL)ETHANONE structure
CAS No.
2732-28-7
Chemical Name:
1-(2-METHYLPYRIDIN-4-YL)ETHANONE
Synonyms
4-Acetyl-2-methylpyridine;1-(2-Methyl-4-pyridyl)ethanone;1-(2-METHYLPYRIDIN-4-YL)ETHANONE;1-(2-Methyl-4-pyridinyl)-Ethanone;Ketone, methyl 2-methyl-4-pyridyl;Ethanone,1-(2-Methyl-4-pyridinyl)-;1-(2-Methylpyridin-4-yl)ethan-1-one
CBNumber:
CB9841594
Molecular Formula:
C8H9NO
Molecular Weight:
135.16
MDL Number:
MFCD07375079
MOL File:
2732-28-7.mol
Last updated:2025-07-24 18:13:45
Product description Number Pack Size Price
1-(2-Methylpyridin-4-yl)ethanone M338008 500mg $175
4-Acetyl-2-methylpyridine W5046 5g $771
4-Acetyl-2-methylpyridine 95+% 073065 1g $1158
1-(2-METHYL-PYRIDIN-4-YL)-ETHANONE 97.00% CHM0125371 250MG $1167.71
4-Acetyl-2-methylpyridine W5046 25g $2451
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1-(2-METHYLPYRIDIN-4-YL)ETHANONE Properties

Melting point 149 °C
Boiling point 130 °C(Press: 4 Torr)
Density 1.036±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 4.25±0.10(Predicted)
Appearance Light yellow to light brown Solid-Liquid Mixture

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-36/37
Safety Statements  26-36/37
HS Code  2933399990

1-(2-METHYLPYRIDIN-4-YL)ETHANONE price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M338008 1-(2-Methylpyridin-4-yl)ethanone 2732-28-7 500mg $175 2021-12-16 Buy
AK Scientific W5046 4-Acetyl-2-methylpyridine 2732-28-7 5g $771 2021-12-16 Buy
Matrix Scientific 073065 4-Acetyl-2-methylpyridine 95+% 2732-28-7 1g $1158 2021-12-16 Buy
American Custom Chemicals Corporation CHM0125371 1-(2-METHYL-PYRIDIN-4-YL)-ETHANONE 97.00% 2732-28-7 250MG $1167.71 2021-12-16 Buy
AK Scientific W5046 4-Acetyl-2-methylpyridine 2732-28-7 25g $2451 2021-12-16 Buy
Product number Packaging Price Buy
M338008 500mg $175 Buy
W5046 5g $771 Buy
073065 1g $1158 Buy
CHM0125371 250MG $1167.71 Buy
W5046 25g $2451 Buy

1-(2-METHYLPYRIDIN-4-YL)ETHANONE Chemical Properties,Uses,Production

Definition

ChEBI: 4-Acetyl-2-methylpyridine is an aromatic ketone.

Synthesis

N-methoxy-N,2-dimethylisonicotinamide

1211580-90-3

Methyllithium

917-54-4

1-(2-METHYLPYRIDIN-4-YL)ETHANONE

2732-28-7

Step 3: Synthesis of 1-(2-methylpyridin-4-yl)ethanone (46d) To a stirred tetrahydrofuran (THF) solution (520 mL) of N-methoxy-N,2-dimethylisonicotinamide (46c) (26 g, 144.28 mmol) under nitrogen protection, methyl lithium (MeLi, 6.342 g, 288.562 mmol, 1M THF solution) was slowly added at -78 °C. The reaction mixture was gradually warmed to room temperature over a period of 1 h, followed by quenching the reaction with saturated ammonium chloride (NH4Cl) solution at 0 °C. The reaction mixture was extracted with ethyl acetate, the organic layers were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting crude product was purified by column chromatography to afford 1-(2-methylpyridin-4-yl)ethanone (46d) (11 g, 56.4% yield) as a slightly red viscous liquid. 1H NMR (CDCl3) δ: 8.61-8.59 (d, 1H), 7.51-7.45 (d, 1H), 7.45-7.44 (m, 1H), 4.05-4.02 (s, 3H). MS (ES+): 136.1 (M + 1).

References

[1] Patent: WO2015/134998, 2015, A1. Location in patent: Page/Page column 840; 841
[2] Patent: WO2017/59178, 2017, A1. Location in patent: Page/Page column 151
[3] Patent: WO2013/19682, 2013, A1. Location in patent: Page/Page column 141; 142
[4] Patent: WO2013/19626, 2013, A1. Location in patent: Page/Page column 34; 35

1-(2-METHYLPYRIDIN-4-YL)ETHANONE Preparation Products And Raw materials

Raw materials

4-Bromo-2-methylpyridine 4-CYANO-2-METHYLPYRIDINE N-methoxy-N,2-dimethylisonicotinamide Methyllithium Methylmagnesium Bromide
TRIBUTYL(1-ETHOXYVINYL)TIN

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Preparation Products

1-(2-METHYLPYRIDIN-4-YL)ETHANONE Suppliers

Global( 82)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43339 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33325 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Shanghai Likang New Materials Co., Limited 		+86-16631818819 +86-17736933208 3684455296@qq.com China 9300 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 info@dycnchem.com China 53899 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Supplier Advantage
Alchem Pharmtech,Inc. 		58
Career Henan Chemica Co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
Shanghai Likang New Materials Co., Limited 		58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		58
DAYANG CHEM (HANGZHOU) CO.,LTD 		58
Amadis Chemical Company Limited 		58

1-(2-METHYLPYRIDIN-4-YL)ETHANONE Spectrum

1-(2-METHYLPYRIDIN-4-YL)ETHANONE(2732-28-7)1HNMR1-(2-METHYLPYRIDIN-4-YL)ETHANONE(2732-28-7)FT-IR

2732-28-7(1-(2-METHYLPYRIDIN-4-YL)ETHANONE)Related Search:

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AURORA KA-8155 1-(6-Methyl-2-phenyl-4-quinolinyl)-2-(4-piperidinyl)ethanone 4-Acetyl-2-cyanopyridine 1-(2-METHYLPYRIDIN-4-YL)ETHANONE 1-(3-AMINO-2-METHYLPYRIDIN-4-YL)ETHANONE
3-(2-PHENYL-QUINOLINE-4-CARBONYL)-1-VINYL-AZEPAN-2-ONE bis[2,8-di(trifluoromethyl)quinolin-4-yl-2-pyridyl] ketone 3-(2-PHENYL-QUINOLINE-4-CARBONYL)-PIPERIDIN-2-ONE Ethanone, 1-(2,6-dimethyl-4-pyridinyl)- (9CI) bostrycoidin
Cyclopropyl-(2-methyl-4-pyridinyl)-methanone

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1-(2-METHYLPYRIDIN-4-YL)ETHANONE 4-Acetyl-2-methylpyridine 1-(2-Methylpyridin-4-yl)ethan-1-one 1-(2-Methyl-4-pyridinyl)-Ethanone Ethanone,1-(2-Methyl-4-pyridinyl)- Ketone, methyl 2-methyl-4-pyridyl 1-(2-Methyl-4-pyridyl)ethanone 2732-28-7 Heterocycle-Pyridine series