3-Cyanopyridine
- CAS No.
- 100-54-9
- Chemical Name:
- 3-Cyanopyridine
- Synonyms
- NICOTINONITRILE;3-PYRIDINECARBONITRILE;Pyridine-3-carbonitrile;3-Cyjanopirydyna;3-Azabenzonitrile;BETA-CYANOPYRIDINE;NICOTINIC ACID NITRILE;Nicotinamide EP Impurity B;3-CYANOPYRIDINE;b-Cyanopyridine
- CBNumber:
- CB9852589
- Molecular Formula:
- C6H4N2
- Molecular Weight:
- 104.11
- MDL Number:
- MFCD00006372
- MOL File:
- 100-54-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Pyridinecarbonitrile 98% | C94807 | 5g | $55.8 |
| 3-Pyridinecarbonitrile 98% | C94807 | 100g | $60.8 |
| 3-Cyanopyridine >98.0%(GC) | C0456 | 25g | $21 |
| 3-Cyanopyridine >98.0%(GC) | C0456 | 500g | $71 |
| 3-Pyridinecarbonitrile Asreported | 287683 | 100g | $302 |
| More product size | |||
| Melting point | 48-52 °C(lit.) |
|---|---|
| Boiling point | 201 °C(lit.) |
| Density | 1.159 |
| refractive index | 1.5242 (estimate) |
| Flash point | 184 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 140g/l |
| form | Crystalline Mass, Crystals or Chunks |
| pka | pK1:1.45(+1) (25°C) |
| color | Colorless or white to yellow |
| Water Solubility | 140 g/L (20 ºC) |
| BRN | 107711 |
| Henry's Law Constant | 3.6×101 mol/(m3Pa) at 25℃, Abraham et al. (1994) |
| Exposure limits | NIOSH: IDLH 25 mg/m3 |
| Stability | Incompatible with strong oxidizing agents, strong reducing agents, strong acids, strong bases. |
| InChI | 1S/C6H4N2/c7-4-6-2-1-3-8-5-6/h1-3,5H |
| InChIKey | GZPHSAQLYPIAIN-UHFFFAOYSA-N |
| SMILES | N#Cc1cccnc1 |
| CAS DataBase Reference | 100-54-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | X64V0K6260 |
| NIST Chemistry Reference | 3-Pyridinecarbonitrile(100-54-9) |
| EPA Substance Registry System | 3-Pyridinecarbonitrile (100-54-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QT3030000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 |
|||||||||
| Hazardous Substances Data | 100-54-9(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Cyanopyridine price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C94807 | 3-Pyridinecarbonitrile 98% | 100-54-9 | 5g | $55.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | C94807 | 3-Pyridinecarbonitrile 98% | 100-54-9 | 100g | $60.8 | 2026-04-30 | Buy |
| TCI Chemical | C0456 | 3-Cyanopyridine >98.0%(GC) | 100-54-9 | 25g | $21 | 2026-04-30 | Buy |
| TCI Chemical | C0456 | 3-Cyanopyridine >98.0%(GC) | 100-54-9 | 500g | $71 | 2026-04-30 | Buy |
| Usbiological | 287683 | 3-Pyridinecarbonitrile Asreported | 100-54-9 | 100g | $302 | 2026-06-03 | Buy |
3-Cyanopyridine Chemical Properties,Uses,Production
Chemical Properties
white to beige solid
Chemical Properties
The cyanopyridines are as follows: 2-cyano-: A white to tan liquid or solid. Almond odor. Boiling point=2213℃ ; freezing/melting point=27℃ ; flash point=89℃ . 3-cyano-: a colorless liquid or gray crystal- line solid.
Uses
3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol.
Definition
ChEBI: A nitrile that is pyridine substituted by a cyano group at position 3.
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 2155, 1988 DOI: 10.1016/S0040-4039(00)86697-6
Potential Exposure
Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period.
Shipping
UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).
Purification Methods
3-Cyanopyridine is recrystallised to constant melting point from o-xylene/hexane. [Beilstein 22/2 V 115.]
Incompatibilities
3-Cyanopyridine is incompatible with oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .
Toxics Screening Level
The Initial Threshold Screening Level (ITSL) for 3-cyanopyridine (also known as nicotinonitrile) is 1.5 μg/m3 with annual averaging time.
3-Cyanopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Dangtong Import and export Co LTD | +86-86-4001020630 +8619831957301 | admin@hbdangtong.com | China | 1000 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 | sales@sjar-tech.com | China | 529 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
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View Lastest Price from 3-Cyanopyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-18 | 3-Cyanopyridine
100-54-9
|
25KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
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2026-06-16 | 3-Cyanopyridine
100-54-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
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2026-06-15 | 3-Cyanopyridine
100-54-9
|
$666.00-999.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD |
-
- 3-Cyanopyridine
100-54-9
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-Cyanopyridine
100-54-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 3-Cyanopyridine
100-54-9
- $666.00-999.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
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