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1,3-Difluorobenzene

1,3-Difluorobenzene Structure
1,3-Difluorobenzene structure
CAS No.
372-18-9
Chemical Name:
1,3-Difluorobenzene
Synonyms
M-DIFLUOROBENZENE;1,3-DFB;1,3-DifL;DIFLOUROBENZENE;m-difluoro-benzen;m-Difluro Benzene;1,3-Difluorbenzol;3-DifluoroBenzene;1?-Difluorobenzene;1,3-DIFLUOROBENZEN
CBNumber:
CB9853566
Molecular Formula:
C6H4F2
Molecular Weight:
114.09
MDL Number:
MFCD00000327
MOL File:
372-18-9.mol
MSDS File:
SDS
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
1,3-Difluorobenzene ≥99% D102008 10g $75.17
1,3-Difluorobenzene ≥99% D102008 100g $137.34
1,3-Difluorobenzene >98.0%(GC) D1626 25g $66
1,3-Difluorobenzene >98.0%(GC) D1626 500g $457
1,3-Difluorobenzene D447510 100g $305
More product size
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1,3-Difluorobenzene Properties

Melting point -59 °C
Boiling point 83 °C
Density 1.163 g/mL at 25 °C(lit.)
vapor pressure 11.034-19.924kPa at 20-38.2℃
refractive index n20/D 1.438(lit.)
Flash point 36 °F
storage temp. Flammables area
solubility 1.1g/l
form Liquid
Specific Gravity 1.163
color Clear colorless to yellow
Water Solubility insoluble
BRN 1904537
Dielectric constant 5.2400000000000002
LogP 2.21-2.52 at 25℃ and pH6.5
CAS DataBase Reference 372-18-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII VO3C26WOC2
NIST Chemistry Reference Benzene, 1,3-difluoro-(372-18-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Danger
Hazard statements  H225
Precautionary statements  P210
Hazard Codes  F,Xn
Risk Statements  11-20-2017/11/20
Safety Statements  7-16-29-33-7/9
RIDADR  UN 1993 3/PG 2
WGK Germany  1
RTECS  CZ5652000
Hazard Note  Highly Flammable
HazardClass  3
PackingGroup  II
HS Code  29036990
Limited Quantities 1.0 L (0.3 gallon) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
2 0

1,3-Difluorobenzene price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D102008 1,3-Difluorobenzene ≥99% 372-18-9 10g $75.17 2025-07-31 Buy
Sigma-Aldrich D102008 1,3-Difluorobenzene ≥99% 372-18-9 100g $137.34 2025-07-31 Buy
TCI Chemical D1626 1,3-Difluorobenzene >98.0%(GC) 372-18-9 25g $66 2025-07-31 Buy
TCI Chemical D1626 1,3-Difluorobenzene >98.0%(GC) 372-18-9 500g $457 2025-07-31 Buy
TRC D447510 1,3-Difluorobenzene 372-18-9 100g $305 2021-12-16 Buy
Product number Packaging Price Buy
D102008 10g $75.17 Buy
D102008 100g $137.34 Buy
D1626 25g $66 Buy
D1626 500g $457 Buy
D447510 100g $305 Buy

1,3-Difluorobenzene Chemical Properties,Uses,Production

Synthesis

Higher yields were observed when CsF and HF were reacted with 1,3-dichlorobenzene, which gave I ,3-difluorobenzene.
synthesis of 1,3-Difluorobenzene

Chemical Properties

1,3-Difluorobenzene (C6H4F2, CAS registry No. 372-18-9) is also named as m-difluorobenzene, which is a clear colorless to yellowish liquid. Its melting point is -59 °C, boiling point is 83 °C and flash point is 2 oC. It is insoluble in water and stable under normal temperatures and pressures. It is toxic and flammable. It will produce toxic fluoride gas by heat.

Uses

1,3-Difluorobenzene has been extensively used in the synthesis of pharmaceutical and pesticide intermediate. For example, it can be used for the synthesis of fluorinated medicine such as Fluconazole, etc. and pesticide (Flucycloxuron, Diflubenzuro, etc.). It can also be used to synthesize liquid crystal materials.

Chemical Properties

CLEAR COLORLESS TO YELLOWISH LIQUID

Uses

It is used in the laser induced fluorencence matrix study of 1,3-difluorobenzene radical cation. It is also used synthesis of 1,2,3-triazole containing fluconazole analogues.

Definition

ChEBI: A difluorobenzene carrying fluoro groups at positions 1 and 3.

1,3-Difluorobenzene Preparation Products And Raw materials

Raw materials

Sodium nitrite Fluoroboric acid Hydrochloric acid m-Phenylenediamine 3-Nitroaniline
Benzene, 1,3-difluoro-2-(triMethylsilyl)- 2,6-Difluoronitrobenzene 2,4-Difluorophenylboronic acid 2,4-Difluorobenzotrifluoride

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Preparation Products

2,4-Difluoronitrobenzene 2,6-Difluorophenol 1-Bromo-2,4-difluorobenzene Fluconazole 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
Risperidone 3,5-Difluorobenzoic acid 3-(2',4'-DIFLUOROPHENYL)-3-OXOPROPANENITRILE 2,4-Difluorophenylacetic acid 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
2',4'-Difluoroacetophenone 3-FLUOROBENZYLOXYBENZENE 1,3-PROPANEDIOL, 2-[2-(2,4-DIFLUOROPHENYL)-2-PROPEN-1-YL]-

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1,3-Difluorobenzene Suppliers

Global( 501)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchemie Shanghai Co.,Ltd.
+8615921545397 cindy_hu@alchemie-shanghai.com China 133 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8757 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5244 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20130 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21604 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Speranza Chemical Co., Ltd. 		+86-86-075521030354 +8618688942810 sophieliu@speranzachem.com China 925 55
Supplier Advantage
Alchemie Shanghai Co.,Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Speranza Chemical Co., Ltd. 		55

Related articles

  • What is 1,3-Difluorobenzene?
  • 1,3-Difluorobenzene (C6H4F2, CAS registry No. 372-18-9) is also named as m-difluorobenzene, which is a clear colorless to yell....
  • Feb 14，2020

View Lastest Price from 1,3-Difluorobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,3-Difluorobenzene pictures 2026-01-05 1,3-Difluorobenzene
372-18-9
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
1,3-Difluorobenzene pictures 2026-01-05 1,3-Difluorobenzene
372-18-9
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
1,3-Difluorobenzene pictures 2025-11-19 1,3-Difluorobenzene
372-18-9
 US $0.00 / kg 20kg 99% 20 tons Qingdao RENAS Polymer Material Co., Ltd.

1,3-Difluorobenzene Spectrum

1,3-Difluorobenzene(372-18-9)MS1,3-Difluorobenzene(372-18-9)1HNMR1,3-Difluorobenzene(372-18-9)13CNMR1,3-Difluorobenzene(372-18-9)IR11,3-Difluorobenzene(372-18-9)Raman

372-18-9(1,3-Difluorobenzene )Related Search:

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2,6-Difluorobenzamide 2,3-Difluorobenzoic acid Transfluthrin 2,3-Difluorophenol 2,6-Difluorobenzoic acid
2,6-Difluorobenzaldehyde 2,6-Difluorobenzonitrile 2-Difluorobenzene,1,2-Difluorobenzene 98%,1,2-Difluorobenzene,98+%,o-Difluorobenzene,99% Pentafluorobenzene DECAFLUOROBENZHYDROL
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1,3-difluroethylene Benzene, m-difluoro- benzene,1,3-difluoro- Benzene,m-difluoro- Between two fluorine benzene 1,3-DifL Difluoro-1,3-benzene m-difluoro-benzen meta-Difluorobenzene M-DIFLUOROBENZENE 1?-Difluorobenzene m-Difluro Benzene 1,3-DIFLUOROBENZEN 1,3-DIFLUOROBENZENE 1,3-DIFLUOROBENZENE, 99+% 1,3-DifluorobenzeneExtraPure DIFLOUROBENZENE 1,3-Difluorbenzol 3-DifluoroBenzene 1,3-DIFLUOROBENZENEFLOCONAZOLE 1,3 DIFLOUROBENZENE extrapure 1,3-difluoro (between the two fluorophenyl) Between difluorobenzene 1,3-Difluorobenzene, 99+% 10ML 1,3-Difluorobenzene > 1,3-Difluorobenzene ISO 9001：2015 REACH Voriconazole Impurity 39 1,3-Difluorobenzene (MDFB) extrapure, 99% 1,3-Difluorobenzene 99% Extrapure 1,3-Di Fluoro Benzene (MDFB) 1,3-Difluorobenzene, 98% 1,3-Difluorobenzene 99% Colorless to light yellow liquid 1,3-DFB 372-18-9 C6H4F2CFCHCFCHCHCH 372189 Building Blocks Aryl Organic Building Blocks Halogenated Hydrocarbons C6 Aryl Fluorinated Building Blocks Building Blocks Chemical Synthesis Fluorinated Building Blocks Halogenated Hydrocarbons Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks alkyl Fluorine Aromatic Hydrocarbons (substituted) & Derivatives Fluorobenzene Fluorine Compounds Aryl Halogenated Hydrocarbons bc0001 K00001 C6