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ChemicalBook >> CAS DataBase List >>3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl-

3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl-

3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl- Structure
3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl- structure
CAS No.
2413944-70-2
Chemical Name:
3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl-
Synonyms
USP7-797;USP7-IN-7;3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl-
CBNumber:
CB99018845
Molecular Formula:
C27H28ClN3O3S
Molecular Weight:
510.05
MDL Number:
MOL File:
2413944-70-2.mol
MSDS File:
SDS
Last updated:2025-10-29 15:43:00
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3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl- Properties

Boiling point 736.2±60.0 °C(Predicted)
Density 1.338±0.06 g/cm3(Predicted)
pka 8.70±0.40(Predicted)
form Solid
color White to off-white

3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0134397 USP7-797 99.09% 2413944-70-2 1mg $505 2026-06-04 Buy
ChemScene CS-0134397 USP7-797 99.09% 2413944-70-2 5mg $1161 2026-06-04 Buy
ChemScene CS-0134397 USP7-797 99.09% 2413944-70-2 10mg $1859 2026-06-04 Buy
ChemScene CS-0134397 USP7-797 99.09% 2413944-70-2 25mg $3358 2026-06-04 Buy
ChemScene CS-0134397 USP7-797 99.09% 2413944-70-2 50mg $5037 2026-06-04 Buy
Product number Packaging Price Buy
CS-0134397 1mg $505 Buy
CS-0134397 5mg $1161 Buy
CS-0134397 10mg $1859 Buy
CS-0134397 25mg $3358 Buy
CS-0134397 50mg $5037 Buy

3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl- Chemical Properties, Uses, Production

Uses

USP7-797 (USP7-IN-7) is an orally available, selective USP7 inhibitor (IC50=0.5 nmol/L) with antitumor activity. USP7-797 reduces the level of MDM2, thereby increasing the stability and activity of p53, leading to cell cycle arrest and apoptosis. USP7-797 has low nanomolar cytotoxicity against p53 mutant cancer cell lines, p53 wild-type hematological tumors, and neuroblastoma cell lines[1][2].

IC 50

USP7: 0.5 nM (IC50)

References

[1] Biannic, Berenger, et al. UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF. US20200095260. 2019.
[2] Ohol YM, et al. Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo. Mol Cancer Ther. 2020 Oct;19(10):1970-1980. DOI:10.1158/1535-7163.MCT-20-0184

3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl- Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
TargetMol Chemicals Inc. 58

3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl- Spectrum

3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl-(2413944-70-2)1HNMR

2413944-70-2 (3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl-) Related Search:

UCHL1 Protein, Rat (His) USP25 Protein, Human USP3 Protein, Human (Active, sf9, GST) P 22077 USP5-IN-1
OTUB1 Protein, Human (His)

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3-Azabicyclo[3.1.0]hexane-2,4-dione, 3-[[7-[5-chloro-3-methyl-2-[(2R)-2-morpholinylmethyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl- USP7-797 USP7-IN-7 2413944-70-2