2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride
![2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride Structure](CAS/20180906/GIF/41544-24-5.gif)
- CAS No.
- 41544-24-5
- Chemical Name:
- 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride
- Synonyms
- Virumerz;Viruserol;Viru-merz;Einecs 255-434-5;Tromantadine HCl;Tromantadin hydrochlorid;N-(Adamantan-1-yl)-2-(2-(dimethylamino)ethoxy)acetamide hydrochloride;2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride
- CBNumber:
- CB9919691
- Molecular Formula:
- C16H28N2O2.ClH
- Molecular Weight:
- 316.86666
- MDL Number:
- MOL File:
- 41544-24-5.mol
- MSDS File:
- SDS
| Melting point | 157-158° |
|---|---|
| form | Solid |
| color | White to off-white |
| FDA UNII | H09LUS437B |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 orally in rats: 630 mg/kg; i.v. in mice: 71.0 mg/kg (Peteri, Sterner) |
|---|
2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | AT183560 | Tromantadine hydrochloride | 41544-24-5 | 5mg | $1103.3 | 2026-06-04 | Buy |
| Biosynth | AT183560 | Tromantadine hydrochloride | 41544-24-5 | 10mg | $1557.6 | 2026-06-04 | Buy |
| Biosynth | AT183560 | Tromantadine hydrochloride | 41544-24-5 | 25mg | $3082.75 | 2026-06-04 | Buy |
| Biosynth | AT183560 | Tromantadine hydrochloride | 41544-24-5 | 50mg | $4543 | 2026-06-04 | Buy |
| Biosynth | AT183560 | Tromantadine hydrochloride | 41544-24-5 | 100mg | $6750 | 2026-06-04 | Buy |
2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride Chemical Properties, Uses, Production
Originator
Viru-Merz,Merz,W. Germany,1973
Uses
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication[1].
Manufacturing Process
Adamantane is first reacted with chloroacetyl chloride to give
chloroacetylaminoadamantane.
2.3 g Na (0.1 g-atom) were dissolved in 75 ml dimethylamino-ethanol. Then
the excess alcohol was distilled off completely and the sodium salt developed
was dried in a vacuum. After drying, the salt was dissolved in about 200 ml
xylene. To thissolution.22.8 g (0.1 mol) chloroacetylaminoadamantane were added, heated for 10 hours under reflux in a 250-ml round-bottomed flask
with a reflux cooler, and the sodium chloride developed subsequently filtered
off.
Next the xylene was distilled away, the liquid residue dissolved in about 80 ml
carbon tetrachloride and the hydrochloride precipitated through introduction of
hydrochloric acid gas. The hydrochloride was dissolved in about 100 ml
acetone and the solvent subsequently distilled away, whereby excess
hydrochloric acid passed over with it. This operation was repeated until no
excess acid was present.
A large excess of petroleum ether was added in a 500 ml three-necked flask
provided with a stirrer and reflux cooler, to a concentrated acetonic solution of
the hydrochloride and stirred for at least 1 hour, whereby the desired
substance was deposited in a crystalline form. Finally, the substance was
filtered away and dried in a desiccator. 14 g of the substance (15% of theory)
were obtained.
Therapeutic Function
Antiviral
IC 50
HSV-1; HSV-2
References
[1] Rosenthal KS, et al. Tromantadine: inhibitor of early and late events in herpes simplex virus replication. Antimicrob Agents Chemother. 1982 Dec;22(6):1031-6. DOI:10.1128/AAC.22.6.1031
2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride Preparation Products And Raw materials
2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
View Latest Price from 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide monohydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Tromantadine hydrochloride
41544-24-5
|
$332.00-1360.00 | 10g | TargetMol Chemicals Inc. |
-
- Tromantadine hydrochloride
41544-24-5
- $332.00-1360.00
- TargetMol Chemicals Inc.
