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ChemicalBook >> CAS DataBase List >>Avermectin A1a, 5-O-demethyl-22,23-dihydro-

Avermectin A1a, 5-O-demethyl-22,23-dihydro-

Avermectin A1a, 5-O-demethyl-22,23-dihydro- Structure
Avermectin A1a, 5-O-demethyl-22,23-dihydro- structure
CAS No.
71827-03-7
Chemical Name:
Avermectin A1a, 5-O-demethyl-22,23-dihydro-
Synonyms
Ivermectin B1a;IvermectinH2B1a;Ivermectin B1a (>85%);Ivermectin Impurity 3;Dihydroavermectin B1a;Ivermectin B1a, 10 mM in DMSO;22,23-dihydroavermectin B1a in Methanol;5-O-Demethyl-22,23-dihydroavermectin A1a;22,23-Dihydro-5-O-demethylavermectin A1a;Avermectin A1a, 5-O-demethyl-22,23-dihydro-
CBNumber:
CB9928288
Molecular Formula:
C48H74O14
Molecular Weight:
875.09
MDL Number:
MOL File:
71827-03-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Avermectin A1a, 5-O-demethyl-22,23-dihydro- Properties

Melting point 155-157°
Boiling point 717.97°C (rough estimate)
Density 1.0683 (rough estimate)
refractive index 1.6130 (estimate)
storage temp. Store at -20°C
solubility Soluble in DMSO
form solid
pka 12.42±0.70(Predicted)
color white
FDA UNII 91Y2202OUW

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
NFPA 704
0
3 0

Avermectin A1a, 5-O-demethyl-22,23-dihydro- price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18768 Ivermectin B1a ≥95% 71827-03-7 5mg $140 2026-04-30 Buy
Cayman Chemical 18768 Ivermectin B1a ≥95% 71827-03-7 25mg $624 2026-04-30 Buy
Usbiological 452818 Ivermectin B1a ≥85% 71827-03-7 5mg $382 2026-06-03 Buy
Usbiological 452818 Ivermectin B1a ≥85% 71827-03-7 10mg $616 2026-06-03 Buy
Biosynth WCA82703 Ivermectin B1a-D2 71827-03-7 1mg $900 2026-06-05 Buy
Product number Packaging Price Buy
18768 5mg $140 Buy
18768 25mg $624 Buy
452818 5mg $382 Buy
452818 10mg $616 Buy
WCA82703 1mg $900 Buy

Avermectin A1a, 5-O-demethyl-22,23-dihydro- Chemical Properties, Uses, Production

Description

Ivermectin B1a is the main component (>80%) of the anthelmintic ivermectin, which also contains ivermectin B1b (<20%; ). It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function (EC50 = 104 nM). Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.

Uses

Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.

Definition

ChEBI: A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.

References

[1] j. wolsetnholme and a. t. rogers. glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. parasitology131 suppl, s85-s95 (2005).
[2] s. gaisser, l. kellenberger, a. l. kaja, et al. direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of streptomyces avermitilis atcc31272. organic & biomolecular chemistry 1(16), 2840-2847 (2003).
[3] j. p. arena, k. k. liu, p. s. paress, et al. the mechanism of action of avermectins in caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. journal of parasitology 81, 286-294 (1995).

Avermectin A1a, 5-O-demethyl-22,23-dihydro- Preparation Products And Raw materials

Raw materials

Preparation Products

4a-Hydroxy Ivermectin

Avermectin A1a, 5-O-demethyl-22,23-dihydro- Suppliers

Global Suppliers ( 83)
Supplier Tel Email Country ProdList Advantage
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 9998 58
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 5641 65
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Jinan blalong chemical co. LTD 2710913286@qq.com 1513643261@qq.com China 14227 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Guangzhou Younan Technology Co., Ltd 020-82000279 18988941452 YN_research@163.com China 2984 58
Supplier Advantage
Guangzhou Ruidi Biotechnology Co., Ltd. 58
BioBioPha Co., Ltd. 65
Quality Control Solutions Ltd. 56
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
BOC Sciences 58
TargetMol Chemicals Inc. 58
Jinan blalong chemical co. LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Guangzhou Younan Technology Co., Ltd 58

View Latest Price from Avermectin A1a, 5-O-demethyl-22,23-dihydro- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ivermectin B1a pictures 2026-07-27 Ivermectin B1a
71827-03-7
 $48.00-197.00 96.18% 10g TargetMol Chemicals Inc.
Ivermectin H2B1a pictures 2025-12-16 Ivermectin H2B1a
71827-03-7
 10mg 95%+ 100000 Moxin Chemicals

Avermectin A1a, 5-O-demethyl-22,23-dihydro- Spectrum

Avermectin A1a, 5-O-demethyl-22,23-dihydro-(71827-03-7)1HNMR

71827-03-7 (Avermectin A1a, 5-O-demethyl-22,23-dihydro-) Related Search:

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IverMectin B1 Aglycon Ivermectin

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22,23-Dihydro-5-O-demethylavermectin A1a 5-O-Demethyl-22,23-dihydroavermectin A1a Dihydroavermectin B1a IvermectinH2B1a (2Ae,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17ar,20R,20ar,20bs)-20,20B-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17A,20,20A,20B-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-L-arabino-hexopyranosyl)-3-o-methyl-alpha-L-arabino-hexopyranoside Avermectin A1a, 5-O-demethyl-22,23-dihydro- Ivermectin Impurity 3 Ivermectin B1a (>85%) Ivermectin B1a-D2Q: What is Ivermectin B1a-D2 Q: What is the CAS Number of Ivermectin B1a-D2 Avermectin,Ivermectin,B1a,COVID-19,Parasite,Inhibitor,SARS coronavirus,Ivermectin B1a,anti-parasite,inhibit,SARS-CoV Ivermectin 2-epimer (Dihydro Avermectin B1a) 22,23-dihydroavermectin B1a in Methanol Ivermectin B1a, 10 mM in DMSO Ivermectin B1a 71827-03-7 Organics