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Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- structure

CAS No.: 2307472-03-1

Chemical Name:: Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-

Synonyms: IU1-248, 10 mM in DMSO;Deubiquitinase,IU1-248,IU1 248,DUBs,IU-1-248,Inhibitor,inhibit,IU1248;4-(3-(2-(4-Hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile;Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-

CBNumber:: CB99379867

Molecular Formula:: C20H23N3O2

Molecular Weight:: 337.42

MDL Number:: MFCD34469381

MOL File:: 2307472-03-1.mol

Last updated:2025-09-29 22:33:22

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Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Properties

Boiling point	566.4±50.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
pka	14.80±0.20(Predicted)
form	Solid
color	Light brown to khaki

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Chemical Properties,Uses,Production

Uses

IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.

Biological Activity

IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM. IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is comparable to that of IU1-47 (IC50=0.68 μM) and 10-fold more potent than that of IU1 (IC50=12.25 μM)[1].

References

[1]. Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Suppliers

Global( 26)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32432	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39031	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4669	55
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	71826	60
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	9848	58
Shanghai SuperLan Chemcial Technique Centre	0-2022843681 15618226720	chaolaichem@foxmail.com	China	10000	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	4808	58
Hubei wei shi reagent group ltd., company	027-59102966 18717199209	2853877583@qq.com	China	2539	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	62320	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Chaolan Chemical Technology Center	58
Shanghai SuperLan Chemcial Technique Centre	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
Hubei wei shi reagent group ltd., company	58
Bide Pharmatech Ltd.	58

View Lastest Price from Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-09-29	IU1-248 2307472-03-1	US $45.00-172.00 / mg		99.30%	10g	TargetMol Chemicals Inc.

IU1-248
2307472-03-1
US $45.00-172.00 / mg
99.30%
TargetMol Chemicals Inc.

Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]- Deubiquitinase,IU1-248,IU1 248,DUBs,IU-1-248,Inhibitor,inhibit,IU1248 4-(3-(2-(4-Hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile IU1-248, 10 mM in DMSO 2307472-03-1